Potential Effects of the MIND Diet in the Management of Neurological Diseases

Öz

Today, the significant increase in the prevalence of neurological diseases, parallel to the increase in the elderly population, is noteworthy. Disability, cognitive impairment, and progressive, debilitating symptoms caused by neurological diseases such as Alzheimer's disease and Parkinson's disease pose a serious burden on both patients and caregivers. Owing to their impact on society, there is a need to develop effective strategies for the prevention and treatment of these diseases. Nutritional lifestyle interventions are important approaches that may have an impact on neurological disease development and progression. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, a combination of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) eating patterns, emphasizes more green leafy vegetables, berries, olive oil, fish, whole grains, nuts, beans, poultry, and less red meat, sugar, and saturated fat. Studies have reported that compliance with the MIND diet is associated with cognitive benefits and may be an effective strategy to reduce the risk of Alzheimer's disease and dementia. The MIND diet may have positive effects on neurological diseases through mechanisms such as establishing a balanced brain-gut microbiota axis, reducing oxidative stress and inflammation, and improving metabolic risk factors. However, the underlying molecular mechanisms remain to be elucidated. In this review, the relationship between the MIND diet and neurological diseases and the possible mechanisms mediating this relationship are examined.

Anahtar Kelimeler

• Alzheimer’s disease
• dietary therapy
• MIND diet
• neurological diseases

Nörolojik Hastalıkların Yönetiminde MIND Diyetinin Potansiyel Etkileri

Öz

Günümüzde yaşlı nüfus artışına paralel olarak nörolojik hastalıkların prevalansında görülen belirgin artış dikkat çekmektedir. Alzheimer, Parkinson hastalığı gibi nörolojik hastalıkların neden olduğu kısıtlılık hali, bilişsel bozukluk, ilerleyici, güçten düşürücü semptomlar hem hasta hem de bakım vericiler üzerinde ciddi bir yük oluşturur. Toplum üzerindeki etkileri nedeniyle bu hastalıkların önlenmesi ve tedavisine yönelik etkili stratejiler geliştirilmesine ihtiyaç duyulmaktadır. Beslenmeye yönelik yaşam tarzı müdahaleleri nörolojik hastalık gelişimi ve ilerlemesi üzerinde etkili olabilecek önemli bir yaklaşımdır. Akdeniz diyeti ve Hipertansiyonu Durdurmaya Yönelik Diyet Yaklaşımları (DASH) beslenme düzenlerinin birleşimi olan Nörodejeneratif Gecikmeye Yönelik Akdeniz-DASH Müdahalesi (MIND) diyeti yeşil yapraklı sebzeler, üzümsü meyveler, zeytinyağı, balık, tam tahıllar, kuruyemiş, kurubaklagiller, kümes hayvanlarının daha fazla, kırmızı et, şeker ve doymuş yağların daha az tüketilmesini vurgulamaktadır. Yapılan çalışmalarda MIND diyetine uyumun bilişsel faydalarla ilişkili olduğu ve Alzheimer hastalığı ve demans riskini azaltmak için etkili bir strateji olabileceği bildirilmiştir. Nörolojik hastalıklarda MIND diyetinin dengeli beyin-bağırsak mikrobiyota ekseni kurulması, oksidatif stres ve inflamasyonun azaltılması, metabolik risk faktörlerinde iyileşme sağlanması gibi mekanizmalarla olumlu etkiler sağladığı düşünülmektedir. Bununla birlikte altta yatan moleküler mekanizmalar halen aydınlatılmayı beklemektedir. Bu derlemede MIND diyetinin nörolojik hastalıklarla ilişkisi ve bu ilişkiye aracılık eden olası mekanizmalar incelenecektir.

Anahtar Kelimeler

• Alzheimer hastalığı
• diyet terapi
• MIND diyeti
• nörolojik hastalıklar

Destekleyen Kurum

Yok

Teşekkür

Yok

Kaynakça

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