The Relationship Between Exercise Habit and Quality of Life in Mild to Moderate Alzheimer’s Disease Patients

Öz

Objective: Despite its many physiological benefits, exercise in the elderly is a tool whose functionality and emotional effectiveness are controversial. In this study, it was aimed to examine the relationship between exercise habit and quality of life in mild-tomoderate Alzheimer’s disease. Material and Method: A total of 73 geriatric people with regular exercise habit (mean age; 68.03±8.98 year) and no exercise ( mean age; 69.22±8.25 year) participated in the study. Sociodemographic characteristics of the patients who had Standardized Mini Mental Tests during their clinical examinations were recorded. Quality of life was evaluated with the Alzheimer’s Disease Quality of Life Scale. The type and frequency of the exercises performed in the last 3 months were asked to the proxies of the patients. Results: Both groups with exercise habits and without exercise were similar in terms of age, gender, cognitive level, and duration of illness (p>0.05). Quality of life total score and quality of life reported by the patient and proxies were higher in the group with exercise habit (p <0.05). It was found that exercise type and frequency were not associated with the quality of life score in the group with exercise habit (p>0.05). Conclusion: The quality of life in mild-to-moderate Alzheimer’s disease patients with regular exercise habit is better than those who do not exercise, regardless of exercise type and frequency. It is recommended that any exercise should be made a regular habit in these patients.

Anahtar Kelimeler

• Alzheimer’s disease
• exercise habit
• quality of life.

Hafif-Orta Evre Alzheimer Hastalarında Egzersiz Alışkanlığı ve Yaşam Kalitesi İlişkisi

Öz

Amaç: Yaşlılarda egzersiz, birçok fizyolojik yararına rağmen, işlevsellik ve duygusal boyutlardaki etkinliği tartışmalı olan bir araçtır. Bu çalışma ile hafif-orta evre Alzheimer hastalarında egzersiz alışkanlığı ile yaşam kalitesi arasındaki ilişkinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, düzenli egzersiz alışkanlığı olan (ortalama yaş; 68,03±8,98 yıl) ve hiç egzersiz yapmayan (ortalama yaş; 69,22±8,25 yıl) toplam 73 yaşlı birey katıldı. Klinik muayeneleri sırasında hastaların sosyodemografik özellikleri kaydedildi ve Standardize Mini Mental Testleri yapıldı. Alzheimer Hastalığı Yaşam Kalitesi Ölçeği ile yaşam kalitesi değerlendirildi. Son 3 ay içerisinde yapılan egzersizlerin türü ve frekansı hasta yakınlarına soruldu. Bulgular: Egzersiz alışkanlığı olan ve egzersiz yapmayan gruplar, yaş, cinsiyet, kognitif düzey ve hastalık süresi açısından benzerdi (p>0,05). Yaşam kalitesi toplam puanı, hasta ve yakını tarafından bildirilen yaşam kalitesi puanı, egzersiz alışkanlığı olan grupta daha yüksekti (p<0,05). Egzersiz alışkanlığı olan grupta, egzersiz tipi ve frekansının yaşam kalitesi ile ilişkili olmadığı bulundu (p>0,05). Sonuç: Düzenli egzersiz alışkanlığı olan hafif-orta evre Alzheimer hastalarında yaşam kalitesi, egzersiz tipi ve frekansından bağımsız olarak egzersiz yapmayanlara göre daha iyidir. Bu hastalarda herhangi bir egzersizin düzenli bir alışkanlık haline getirilmesi önerilmektedir.

Anahtar Kelimeler

• Alzheimer hastalığı
• egzersiz alışkanlığı
• yaşam kalitesi

Kaynakça

1. Shikimoto R, Nakaaki S, Sato J, Sato H, Mimura M. Comparison of various items of the quality of life in Alzheimer’s disease scale (QOL-AD) in patients with mild or moderate stages of dementia: A cross-sectional study. Psychogeriatrics. 2020 Nov;20(6):926-928.
2. Sampaio A, Marques-Aleixo I, Seabra A, Mota J, Marques E, Carvalho J. Physical fitness in institutionalized older adults with dementia: association with cognition, functional capacity and quality of life. Aging Clin Exp Res. 2020 Nov;32(11):2329-2338.
3. Maresova P, Hruska J, Klimova B, Barakovic S, Krejcar O. Activities of daily living and associated costs in the most widespread neurodegenerative diseases: A systematic review. Clin Interv Aging. 2020 Oct 2.15:1841-1862.
4. Keleş E, Özalevli S. Alzheimer hastalığı ve tedavi yaklaşımları. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 2018, 3(2): 39- 42.
5. T.C. Aile, Çalışma ve Sosyal Hizmetler Bakanlığı Engelli ve Yaşlı Hizmetleri Genel Müdürlüğü. Yaşlı nüfusun demografik değişimi (2020). 2020. Available from: https://www.ailevecalisma.gov.tr/media/45354/yasli-nufus-demografik-degisimi-2020.pdf
6. Lima S, Sevilha S, Pereira MG. Quality of life in early-stage Alzheimer’s disease: The moderator role of family variables and coping strategies from the patients’ perspective. Psychogeriatrics. 2020 Sep;20(5):557-567.
7. Junge S, Gellert P, O’Sullivan JL, Möller S, Voigt-Antons JN, Kuhlmey A, et al. Quality of life in people with dementia living in nursing homes: validation of an eight-item version of the QUALIDEM for intensive longitudinal assessment. Qual Life Res. 2020 Jun;29(6):1721-1730.
8. O’Shea E, Hopper L, Marques M, Gonçalves-Pereira M, Woods B, Jelley H, et al. A comparison of self and proxy quality of life ratings for people with dementia and their carers: a European prospective cohort study. Aging Ment Health. 2020 Jan;24(1):162-170.

9. Zucchella C, Bartolo M, Bernini S, Picascia M, Sinforiani E. Quality of life in Alzheimer disease: A comparison of patients’ and caregivers’ points of view. Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):50-4.
10. World Health Organization. Measuring quality of life: The development of the World Health Organization Quality of Life Instrument (WHOQOL). Geneva: WHO, 1993
11. Song D, Yu DS, Li PW, He G, Sun Q. Correlates of Health-Related Quality of Life Among Chinese Older Adults with Mild Cognitive Impairment. Clin Interv Aging. 2019 Dec 16; 14:2205-2212.
12. Ojagbemi A, Akin-Ojagbemi N. Exercise and quality of life in dementia: A systematic review and meta-analysis of randomized controlled trials. J Appl Gerontol. 2019 Jan;38(1):27-48.
13. Bhatti GK, Reddy AP, Reddy PH, Bhatti JS. Lifestyle modifications and nutritional interventions in aging-associated cognitive decline and Alzheimer’s disease. Front Aging Neurosci. 2020 Jan 10; 11:369.
14. Watson J, O’Keeffe N, West SL. The importance of exercise in Alzheimer’s disease and the Minds in Motion® Program: An editorial. J Funct Morphol Kinesiol. 2020 Aug 4;5(3):59.
15. Dauwan M, Begemann MJH, Slot MIE, Lee EHM, Scheltens P, Sommer IEC. Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials. J Neurol. 2019 Aug 14.
16. Sampaio A, Marques-Aleixo I, Seabra A, Mota J, Marques E, Carvalho J. Physical fitness in institutionalized older adults with dementia: Association with cognition, functional capacity and quality of life. Aging Clin Exp Res. 2020 Nov;32(11):2329-2338.
17. Tavares BB, Moraes H, Deslandes AC, Laks J. Impact of physical exercise on quality of life of older adults with depression or Alzheimer’s disease: a systematic review. Trends Psychiatry Psychother. 2014 Sep;36(3):134-9.
18. Enette L, Vogel T, Merle S, Valard-Guiguet AG, Ozier-Lafontaine N, Neviere R, et al. Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer’s disease: A randomized controlled trial. Eur Rev Aging Phys Act. 2020 Jan 6; 17:2.
19. Borges-Machado F, Ribeiro Ó, Sampaio A, Marques-Aleixo I, Meireles J, Carvalho J. Feasibility and impact of a multicomponent exercise intervention in patients with Alzheimer’s disease: A pilot study. Am J Alzheimers Dis Other Demen. 2019 Mar;34(2):95-103.
20. Arrieta H, Rezola-Pardo C, Echeverria I, Iturburu M, Gil SM, Yanguas JJ, et al. Physical activity and fitness are associated with verbal memory, quality of life and depression among nursing home residents: preliminary data of a randomized controlled trial. BMC Geriatr. 2018 Mar 27;18(1):80.
21. Song D, Yu DSF. Effects of a moderate-intensity aerobic exercise programme on the cognitive function and quality of life of community-dwelling elderly people with mild cognitive impairment: A randomised controlled trial. Int J Nurs Stud. 2019 May; 93:97-105.
22. Lamb SE, Sheehan B, Atherton N, Nichols V, Collins H, Mistry D, et al. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: Randomised controlled trial. BMJ. 2018 May 16;361:k1675.
23. Nieman DC. You asked for it, ACSM’s Health & Fitness Journal. 2008 May; 12 (3):5-6.
24. World Health Organization. Global Recommendations on Physical Activity for Health. 2011. Available from: https://www.who.int/dietphysicalactivity/physical-activity-recommendations-65years.pdf
25. Farina N, Hughes LJ, Watts A, Lowry RG. Use of physical activity questionnaires in people with dementia: A scoping review. J Aging Phys Act. 2019 Jun 1;27(3):413-421.
26. Lawton MP. Quality of life in Alzheimer disease. Alzheimer Dis Assoc Disord. 1994;8(3):138-50.
27. Folstein M.F., Folstein S., Mc Hugh P.R. “Mini Mental State” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12, 189-198.
28. Güngen C, Ertan T, Eker E et al. Standardize mini mental testing Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi. 2002;13(4): 273-281.
29. Farina N, King D, Burgon C, Berwald S, Bustard E, Feeney Y, et al. Disease severity accounts for minimal variance of quality of life in people with dementia and their carers: analyses of cross-sectional data from the MODEM study. BMC Geriatr. 2020 Jul 6;20(1):232.
30. Stypa V, Haussermann P, Fleiner T, Neumann S. Validity and reliability of the German Quality of Life-Alzheimer’s Disease (QoL-AD) Self-Report Scale. J Alzheimers Dis. 2020;77(2):581-590.
31. Zucchella C, Bartolo M, Bernini S, Picascia M, Sinforiani E. Quality of life in Alzheimer disease: a comparison of patients’ and caregivers’ points of view. Alzheimer Dis Assoc Disord. 2015 Jan-Mar;29(1):50-4.
32. Andrieu S, Coley N, Rolland Y, Cantet C, Arnaud C, Guyonnet S, Nourhashemi F, Grand A, Vellas B; PLASA group. Assessing Alzheimer’s disease patients’ quality of life: Discrepancies between patient and caregiver perspectives. Alzheimers Dement. 2016 Apr;12(4):427-37.
33. Abd El-Kader SM, Al-Jiffri OH. Aerobic exercise improves quality of life, psychological well-being and systemic inflammation in subjects with Alzheimer’s disease. Afr Health Sci. 2016 Dec;16(4):1045-1055.
34. Yu F, Nelson NW, Savik K, Wyman JF, Dysken M, Bronas UG. Affecting cognition and quality of life via aerobic exercise in Alzheimer’s disease. West J Nurs Res. 2013 Jan;35(1):24-38.