Production and Characterization of Novel Functional Nanocomposites For Dental Applications

Yıl 2021, Cilt: 9 Sayı: 3, 1027 - 1043, 29.11.2021

Ayşe Aslan , Sedef Kaptan Usul

https://doi.org/10.33715/inonusaglik.850453

Öz

In this study, a new generation antimicrobial azole-containing dental composite has been developed and evaluated. Polymerization has been realized by dispersing 1,2,4-Triazole, 3-amino-1,2,4-t-Triazole ve 5-Aminotetrazole functional SiO2 nanoparticles homogeneously into the resin. Azole-containing dental composites were characterized by FTIR spectroscopy to confirm the binding of azole-containing nanoparticles to BisGMA/TEGDMA resin. Scanned electron microscopic analysis results confirmed the homogeneous distribution of azole nanoparticles in the dental composites. X-ray diffraction studies have shown that the amorphous character of the materials is improved by the incorporation of azole nanoparticles into the structure. By thermogravimetric and differential scanning calorimetric analyzes, it has been determined that the thermal stability of azole dental composites greatly increased with the increase of nanoparticle content at low temperatures. The solubility and absorption of dental composites in water have been observed by keeping them in 37ºC distilled water, and their compliance with ISO requirements has been observed. The fact that the azole-containing dental composites show antimicrobial activity is the proof that they can be used in dentistry applications.

Anahtar Kelimeler

dental composites, nanoparticles, triazole, 3 amino triazole, 5 amino tetrazole

DENTAL UYGULAMALAR İÇİN YENİ NESİL FONKSİYONEL NANOKOMPOZİTLERİN HAZIRLANMASI VE KARAKTERİZASYONU

Öz

Bu çalışmada, yeni nesil antimikrobiyal, azol içerikli dental kompozit geliştirilmiş ve değerlendirilmiştir. 1,2,4-Triazol, 3-amino-1,2,4-t-Triazol ve 5-Aminotetrazol fonksiyonel SiO2 nanopartiküller, reçine içerisine homojen olarak dağıtılarak polimerizasyon gerçekleştirilmiştir. Azol içerikli dental kompozitler, azol içerikli nanopartiküllerin BisGMA/TEGDMA reçineye bağlanmasını doğrulamak için FTIR spektroskopisi ile karakterize edildi. Taramalı elektron mikroskop analiz sonuçları, azollü nanopartiküllerin dental kompozit içerisinde homojen dağılımını doğrulamıştır. X-ışını kırınım çalışmaları, malzemelerin amorf karakterinin azollü nanopartiküllerin yapıya katılması ile geliştiğini göstermiştir. Termogravimetrik ve diferansiyel taramalı kalorimetrik analizleri ile düşük sıcaklıklarda, azollü dental kompozitlerin termal kararlılığının nanopartikül içeriğinin artışı ile büyük oranda arttığı belirlenmiştir. Dental kompozitlerin suda çözünürlükleri ve emilimleri 37ºC’ de saf su içerisinde bekletilerek gözlemlenmiş, ISO şartlarına uygunluğu görülmüştür. Azol içeren dental kompozitlerin antimikrobiyal aktivite göstermesi, diş hekimliği uygulamalarında kullanılabileceğinin kanıtıdır.

Anahtar Kelimeler

dental kompozitler, nanopartiküller, triazol, 3 amino triazole, 5 amino tetrazole

Kaynakça

• Abd El-Fattah, M., El Saeed, A. M., El-Ghazawy, R. A. (2019). Chemical interaction of different sized fumed silica with epoxy via ultrasonication for improved coating. Progress in Organic Coatings, 129, 1-9.
• Aboelnaga, A., Shaarawy, S., Hagar, M. (2017). A novel chitosan 3-amino-1, 2, 4-triazole hybrid: Preparation and its effects on cotton fabric properties. Journal of Taibah University for Science, 11(5), 768-774.
• Al-Odayni, A. B., Alfotawi, R., Khan, R., Saeed, W. S., Al-Kahtani, A., Aouak, T., Alrahlah, A. (2019). Synthesis of chemically modified BisGMA analog with low viscosity and potential physical and biological properties for dental resin composite. Dental Materials, 35(11), 1532-1544.
• Almousa, R., Wen, X., Anderson, G. G., Xie, D. (2019). An improved dental composite with potent antibacterial function. The Saudi dental journal, 31(3), 367-374.
• Aslan, A., Bozkurt, A. (2010). Bioinspired Blend Membranes Based on Adenine and Guanine Functional Poly (glycidyl methacrylate). Langmuir, 26(16), 13655-13661.
• Aslan, A., Elanthikkal, S., Bozkurt, A. (2019a). Chitosan/hollow silica sphere nanocomposites for wound healing application. Journal of Materials Research, 34(2), 231-239.
• Aslan, A., Gümüşdereli, E., Soydan, A. M. (2019b). PEM yakıt hücresi uygulamaları için imidazol fonksiyonel nano SiO2/Nafyon nanokompozit membranların üretilmesi. Gazi Üniversitesi Mühendislik-Mimarlık Fakültesi Dergisi, 34(1), 351-364.
• Azizabadi, O., Akbarzadeh, F., Sargazi, G., Chauhan, N. P. S. (2020). Preparation of a Novel Ti-metal Organic Framework Porous Nanofiber Polymer as an Efficient Dental Nano-coating: Physicochemical and Mechanical Properties. Polymer-Plastics Technology and Materials, 1-10.
• Barot, T., Rawtani, D., Kulkarni, P., Hussain, C. M., Akkireddy, S. (2020). Physicochemical and biological assessment of flowable resin composites incorporated with farnesol loaded halloysite nanotubes for dental applications. Journal of the Mechanical Behavior of Biomedical Materials, 104, 103675.
• Caneli, G., Chen, Y., Sungsoo, N., Anderson, G. G., Xie, D. (2020). A dental filling composite resin restorative with improved antibacterial function and hardness. Journal of Composite Materials, 0021998320947144.
• Cudziło, S., Nita, M. (2010). Synthesis and explosive properties of copper (II) chlorate (VII) coordination polymer with 4-amino-1, 2, 4-triazole bridging ligand. Journal of hazardous materials, 177(1-3), 146-149.
• Djemoui, A., Naouri, A., Ouahrani, M. R., Djemoui, D., Lahcene, S., Lahrech, M. B., Monteiro, F. L. (2020). A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+. Journal of Molecular Structure, 1204, 127487.
• Ficai, M., Andronescu, E., Ficai, A., Voicu, G., VASILE, B. Ş. (2011). Poly bis-GMA/HA based hybrid composite materials. UPB Sci Bull, Series B, 73, 75-84.
• Ghosh, S. (2020). Ceramic and glass-ceramic fillers in dental composites-A review. Journal of Metals, Materials and Minerals, 30(2), 22-30.
• Gökalp, M., Dede, B., Tilki, T., Atay, Ç. K. (2020). Triazole based azo molecules as potential antibacterial agents: Synthesis, characterization, DFT, ADME and molecular docking studies. Journal of Molecular Structure, 1212, 128140.
• Grytsai, O., Valiashko, O., Penco-Campillo, M., Dufies, M., Hagege, A., Demange, L., Benhida, R. (2020). Synthesis and biological evaluation of 3-amino-1, 2, 4-triazole derivatives as potential anticancer compounds. Bioorganic Chemistry, 104, 104271.
• Han, M., Cheng, X., Gao, Z., Zhao, R., Zhang, S. (2017). Inhibition of tumor cell growth by adenine is mediated by apoptosis induction and cell cycle S phase arrest. Oncotarget, 8(55), 94286-94296.
• Jandt, K. D., Watts, D. C. (2020). Nanotechnology in dentistry: Present and future perspectives on dental nanomaterials. Dental Materials, 36, 1365-1378.
• Kaushik, C. P., Sangwan, J., Luxmi, R., Kumar, D., Kumar, D., Das, A., Singh, D. (2021). Design, synthesis, anticancer and antioxidant activities of amide linked 1, 4-disubstituted 1, 2, 3-triazoles. Journal of Molecular Structure, 1226, 129255.
• Lamanna, M. E., de la Horra, E., Jacobo, S., D’Accorso, N. B. (2009). Synthesis of an organic semiconductor by polimerization of 3-amino-1, 2, 4-triazole. Reactive and Functional Polymers, 69(10), 759-765.
• Lee, M. J., Kim, M. J., Kwon, J. S., Lee, S. B., & Kim, K. M. (2017). Cytotoxicity of light-cured dental materials according to different sample preparation methods. Materials, 10(3), 288.
• Leng, P. B., Md Akil, H., Hui Lin, O. (2007). Thermal properties of microsilica and nanosilica filled polypropylene composite with epoxy as dispersing aid. Journal of reinforced plastics and composites, 26(8), 761-770.
• Li, S., Yu, X., Liu, F., Deng, F., He, J. (2020). Synthesis of antibacterial dimethacrylate derived from niacin and its application in preparing antibacterial dental resin system. Journal of the Mechanical Behavior of Biomedical Materials, 102, 103521.
• Luo, S., Liu, F., He, J. (2019). Preparation of low shrinkage stress dental composite with synthesized dimethacrylate oligomers. Journal of the mechanical behavior of biomedical materials, 94, 222-228.
• Mohamed, D. S., El-Baky, A., Mahmoud, R., Sandle, T., Mandour, S. A., Ahmed, E. F. (2020). Antimicrobial Activity of Silver-Treated Bacteria against Other Multi-Drug Resistant Pathogens in Their Environment. Antibiotics, 9(4), 181.
• Moreno-Fuquen, R., Hincapié-Otero, M. M., Becerra, D., Castillo, J. C., Portilla, J., Macías, M. A. 2020. Synthesis of 1-aroyl-3-methylsulfanyl-5-amino-1, 2, 4-triazoles and their analysis by spectroscopy, X-ray crystallography and theoretical calculations. Journal of Molecular Structure, 1226, 129317.
• Rodríguez, H. A., Kriven, W. M., Casanova, H. (2019). Development of mechanical properties in dental resin composite: Effect of filler size and filler aggregation state. Materials Science and Engineering: C, 101, 274-282.
• Song, L., Ye, Q., Ge, X., Misra, A., Tamerler, C., Spencer, P. (2019). New silyl-functionalized BisGMA provides autonomous strengthening without leaching for dental adhesives. Acta biomaterialia, 83, 130-139.
• Tittal, R. K., Vikas, D. G., Yadav, P., Lal, K., Kumar, A. (2020). Synthesis, Antimicrobial Potency with In Silico Study of Boc-Leucine-1, 2, 3-Triazoles. Steroids, 108675.
• Trivedi, M. K., Tallapragada, R. M., Branton, A., Trivedi, D., Nayak, G., Mishra, R., Jana, S. (2015). Characterization of physical, spectral and thermal properties of biofield treated 1, 2, 4-Triazole.
• Wang, Y., Costin, S., Zhang, J. F., Liao, S., Wen, Z. T., Lallier, T., Xu, X. (2018). Synthesis, antibacterial activity, and biocompatibility of new antibacterial dental monomers. American journal of dentistry, 31(SP IS B), 17B-23B
• Wassel, M. O., Khattab, M. A. (2017). Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes. Journal of advanced research, 8(4), 387-392.
• Wu, M., Zhang, F., Yu, J., Zhou, H., Zhang, D., Hu, C., Huang, J. (2014). Fabrication and evaluation of light-curing nanocomposite resins filled with surface-modified TiO 2 nanoparticles for dental application. Iranian Polymer Journal, 23(7), 513-524.
• Yadav, R., Kumar, M. (2019). Dental restorative composite materials: A review. Journal of Oral Biosciences, 61(2), 78-83, 488-495.
• Zhang, D., Cao, C. Y., Lu, S., Cheng, Y., Zhang, H. P. (2019). Experimental insight into catalytic mechanism of transition metal oxide nanoparticles on combustion of 5-Amino-1H-Tetrazole energetic propellant by multi kinetics methods and TG-FTIR-MS analysis. Fuel, 245, 78-88.