Araştırma Makalesi
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Tip 2 Diyabet Mellituslu Hastalarda Obstrüktif Uyku Apnesi ve Kardiyovasküler Risk Faktörleri

Yıl 2022, Cilt: 10 Sayı: 2, 450 - 461, 20.06.2022
https://doi.org/10.33715/inonusaglik.1049837

Öz

Bu çalışmanın amacı, Tip 2 diyabetli erişkin hastalarda obstrüktif uyku apnesi (OSA) ve kardiyovasküler hastalık (KVH) risk faktörlerini belirlemektir. Kesitsel tipte olan bu çalışmada veriler 3 Mart - 15 Temmuz 2016 tarihleri arasında 228 tip 2 diyabet hastasından "Hasta Bilgi Formu", "Berlin Anketi" ve "Framingham Risk Skoru" kullanılarak toplanmıştır. Bu çalışmada OSA risk düzeyi ve hastaları etkileyen faktörler değerlendirildi. Diyabetik hastalarda; cinsiyet, Framingham risk skoru, VKİ, bel/kalça oranı ve bel çevresinin OSA riskini istatistiksel olarak anlamlı derecede artırdığı bulundu. Verilerimiz Tip 2 diyabetli hastalarda uyku bozukluğunun yaygın olduğunu ve OSA için yüksek risk altındaki bireylerin de KVH için daha yüksek risk altında olduğunu göstermektedir. OSA, Tip 2 diyabetli hastalarda KVH riskini artırıyor gibi görünmektedir. Sağlık çalışanları diyabetik hastalara bakım verirken uyku bozukluğu belirtileri değerlendirilmelidir. Diyabetik hastaların eğitim programlarında uyku bozukluğu semptomları ve yönetimi dahil edilmelidir.

Kaynakça

  • Alonderis, A., Varoneckas, G., Raskauskiene, N. & Brozaitiene, J. (2017). Prevalence and predictors of sleep apnea in patients with stable coronary artery disease: A cross-sectional study. Therapeutics and Clinical Risk Management, 13, 1031–1042. https://doi.org/10.2147/TCRM.S136651
  • Archontogeorgis, K., Voulgaris, A., Nena, E., Strempela, M., Karailidou, P., Tzouvelekis, A., …Steiropoulos, P. (2018). Cardiovascular risk assessment in a cohort of newly diagnosed patients with obstructive sleep apnea syndrome. Cardiology Research and Practice, 6572785. https://doi.org/10.1155/2018/6572785
  • Acar, V.H., Kaya, A., Genc, F., Erdem, M., Ceyhan, A., Özgen, F., …Dikmen, B. (2013). Can Berlin questionnaire be used a screening test for obstructive sleep apnea? Journal of Ansetesia, 21, 99-105.
  • Atılgan, K., Demirdas, E. & Cicekcioglu, F. (2018). Effect of obstructive sleep apne syndrome on cardiac and vascular diseases. Bozok Med. J, (Special issue), 92-95.
  • Benjafield, A. V., Ayas, N. T., Eastwood, P. R., Heinzer, R., Ip, M., Morrell, M. J., …Malhotra, A. (2019). Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. The Lancet. Respiratory Medicine, 7(8), 687–698. https://doi.org/10.1016/S2213-2600(19)30198-5
  • Briançon-Marjollet, A., Weiszenstein, M., Henri, M., Thomas, A., Godin-Ribuot, D. & Polak, J. (2015). The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms. Diabetology & Metabolic Syndrome, 7, 25. https://doi.org/10.1186/s13098-015-0018-3
  • Bouloukaki, I., Mermigkis, C., Markakis, M., Pataka, A., Alexaki, I., Ermidou, C., …Schiza, S. E. (2019). Cardiovascular effect and symptom profile of obstructive sleep apnea: does sex matter?. Journal of Clinical Sleep Medicine: JCSM : Official publication of the American Academy of Sleep Medicine, 15(12), 1737–1745. https://doi.org/10.5664/jcsm.8074
  • Costanzo, M. R., Khayat, R., Ponikowski, P., Augostini, R., Stellbrink, C., Mianulli, M., …Abraham, W. T. (2015). Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. Journal of the American College of Cardiology, 65(1), 72–84. https://doi.org/10.1016/j.jacc.2014.10.025
  • Drager, L. F., Santos, R. B., Silva, W. A., Parise, B. K., Giatti, S., Aielo, A. N., …Bensenor, I. M. (2019). OSA, short sleep duration, and their ınteractions with sleepiness and cardiometabolic risk factors in adults: The ELSA-Brasil study. Chest, 155(6), 1190–1198. https://doi.org/10.1016/j.chest.2018.12.003
  • Dursunoğlu, D. & Dursunoğlu, N.(2018). Cardiovascular diseases and sleep disordered breathing: what to do and what to watch? Turkiye Klinikleri J Cardiol-Special Topics,11,73-76.
  • Fietze, I., Laharnar, N., Obst, A., Ewert, R., Felix, S. B., Garcia, C., …Penzel, T. (2019). Prevalence and association analysis of obstructive sleep apnea with gender and age differences - Results of SHIP-Trend. Journal of Sleep Research, 28(5), e12770. https://doi.org/10.1111/jsr.12770
  • Huang, T., Lin, B. M., Markt, S. C., Stampfer, M. J., Laden, F., Hu, F. B., …Redline, S. (2018). Sex differences in the associations of obstructive sleep apnoea with epidemiological factors. The European Respiratory Journal, 51(3), 1702421. https://doi.org/10.1183/13993003.02421-2017
  • Kannel, W. B., McGee, D. & Gordon, T. (1976). A general cardiovascular risk profile: the Framingham Study. The American Journal of Cardiology, 38(1), 46–51. https://doi.org/10.1016/0002-9149(76)90061-8
  • Mehra R. (2019). Sleep apnea and the heart. Clevel and Clinic Journal of Medicine, 86(9 Suppl 1), 10–18. https://doi.org/10.3949/ccjm.86.s1.03
  • Meszaros, M., Tarnoki, A. D., Tarnoki, D. L., Kovacs, D. T., Forgo, B., Lee, …Bikov, A. (2020). Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study. Journal of Sleep Research, 29(4), e12979. https://doi.org/10.1111/jsr.12979
  • Mokhlesi, B., Temple, K. A., Tjaden, A. H., Edelstein, S. L., Nadeau, K. J., Hannon, T. S., …Van Cauter, E. (2019). The association of sleep disturbances with glycemia and obesity in youth at risk for or with recently diagnosed type 2 diabetes. Pediatric Diabetes, 20(8), 1056–1063. https://doi.org/10.1111/pedi.12917
  • Muñoz-Torres, Z., Jiménez-Correa, U. & Montes-Rodríguez, C. J. (2020). Sex differences in brain oscillatory activity during sleep and wakefulness in obstructive sleep apnea. Journal of Sleep Research, 29(4), e12977. https://doi.org/10.1111/jsr.12977
  • Obaseki, D. O., Kolawole, B. A., Gomerep, S. S., Obaseki, J. E., Abidoye, I. A., Ikem, R. T., …Erhabor, G. E. (2014). Prevalence and predictors of obstructive sleep apnea syndrome in a sample of patients with type 2 Diabetes Mellitus in Nigeria. Journal of the Nigeria Medical Association, 55(1), 24–28. https://doi.org/10.4103/0300-1652.128154
  • Oktay Arslan, B. & Ardıç, S. (2018). Obstructive sleep apnea syndrome and cardiometabolic consequences. Turkiye Klinikleri J Pulm Med-Special Topics, 11, 168-173.
  • Shah, N., Allison, M., Teng, Y., Wassertheil-Smoller, S., Sotres-Alvarez, D., Ramos, A. R., …Kaplan, R. C. (2015). Sleep apnea is independently associated with peripheral arterial disease in the Hispanic community health study/study of latinos. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(3), 710–715. https://doi.org/10.1161/ATVBAHA.114.304625
  • Ralls, F. & Cutchen, L. (2019). A contemporary review of obstructive sleep apnea. Current Opinion in Pulmonary Medicine, 25(6), 578–593. https://doi.org/10.1097/MCP.0000000000000623
  • Turkey Nutrition Guide. (TÜBER 2015). (2016). Turkish Republic Ministry of Health Publication. No, 1031, Ankara.
  • Umoh, V. A., Akpan, E. E., Ekrikpo, U. E., Idung, A. U. & Ekpe, E. E. (2020). The risk of obstructive sleep apnea among patients with type 2 diabetes mellitus. Journal of the Nigeria Medical Association, 61(1), 32–36. https://doi.org/10.4103/nmj.NMJ_129_19
  • Wali, S. O., Abalkhail, B. & Krayem, A. (2017). Prevalence and risk factors of obstructive sleep apnea syndrome in a Saudi Arabian population. Annals of Thoracic Medicine, 12(2), 88–94. https://doi.org/10.4103/1817-1737.203746
  • Wilson, P. W., D'Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H. & Kannel, W. B. (1998). Prediction of coronary heart disease using risk factor categories. Circulation, 97(18), 1837–1847. https://doi.org/10.1161/01.cir.97.18.1837
  • World Health Organisation (WHO 2020). In 20 September 2020 retrieved from://www.who.int/news-room/fact-sheets/detail/diabetes.
  • Viswanathan, V., Ramalingam, I. P. & Ramakrishnan, N. (2017). High prevalence of obstructive sleep apnea among people with type 2 diabetes mellitus in a tertiary care center. The Journal of the Association of Physicians of India, 65(11), 38–42.
  • Zhu, Z., Zhang, F., Liu, Y., Yang, S., Li, C., Niu, Q. & Niu, J. (2017). Relationship of obstructive sleep apnoea with diabetic retinopathy: A meta-analysis. Biomed Research International, 4737064. https://doi.org/10.1155/2017/4737064

OBSTRUCTIVE SLEEP APNEA AND CARDIOVASCULAR RISK FACTORS IN THE PATIENTS WITH TYPE 2 DIABETES MELLITUS

Yıl 2022, Cilt: 10 Sayı: 2, 450 - 461, 20.06.2022
https://doi.org/10.33715/inonusaglik.1049837

Öz

The aim of this study is to determine the risk factors of obstructive sleep apnea (OSA) and cardiovascular diseases (CVD) in adult patients with Type 2 diabetes. In this cross-sectional study, the data have been collected from 228 type 2 diabetes patients by using the "Patient Information Form," "Berlin Survey," and "Framingham Risk Score" between March 3 and July 15, 2016. The OSA risk level and factors affecting patients were assessed in this study. Gender, Framingham risk score, BMI, waist/hip ratio, and waist circumference were found to statistically significantly increase the risk of OSA in patients with diabetes. Our data suggest that sleep disturbance is common in patients with Type 2 diabetes, and individuals at high risk for OSA are also at higher risk for CVD. OSA appears to increase the risk of CVD in patients with Type 2 diabetes. When healthcare professionals care for diabetic patients, symptoms of sleep disorders should be evaluated. Sleep disorder symptoms and management should be included in the education programs of diabetic patients.

Kaynakça

  • Alonderis, A., Varoneckas, G., Raskauskiene, N. & Brozaitiene, J. (2017). Prevalence and predictors of sleep apnea in patients with stable coronary artery disease: A cross-sectional study. Therapeutics and Clinical Risk Management, 13, 1031–1042. https://doi.org/10.2147/TCRM.S136651
  • Archontogeorgis, K., Voulgaris, A., Nena, E., Strempela, M., Karailidou, P., Tzouvelekis, A., …Steiropoulos, P. (2018). Cardiovascular risk assessment in a cohort of newly diagnosed patients with obstructive sleep apnea syndrome. Cardiology Research and Practice, 6572785. https://doi.org/10.1155/2018/6572785
  • Acar, V.H., Kaya, A., Genc, F., Erdem, M., Ceyhan, A., Özgen, F., …Dikmen, B. (2013). Can Berlin questionnaire be used a screening test for obstructive sleep apnea? Journal of Ansetesia, 21, 99-105.
  • Atılgan, K., Demirdas, E. & Cicekcioglu, F. (2018). Effect of obstructive sleep apne syndrome on cardiac and vascular diseases. Bozok Med. J, (Special issue), 92-95.
  • Benjafield, A. V., Ayas, N. T., Eastwood, P. R., Heinzer, R., Ip, M., Morrell, M. J., …Malhotra, A. (2019). Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. The Lancet. Respiratory Medicine, 7(8), 687–698. https://doi.org/10.1016/S2213-2600(19)30198-5
  • Briançon-Marjollet, A., Weiszenstein, M., Henri, M., Thomas, A., Godin-Ribuot, D. & Polak, J. (2015). The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms. Diabetology & Metabolic Syndrome, 7, 25. https://doi.org/10.1186/s13098-015-0018-3
  • Bouloukaki, I., Mermigkis, C., Markakis, M., Pataka, A., Alexaki, I., Ermidou, C., …Schiza, S. E. (2019). Cardiovascular effect and symptom profile of obstructive sleep apnea: does sex matter?. Journal of Clinical Sleep Medicine: JCSM : Official publication of the American Academy of Sleep Medicine, 15(12), 1737–1745. https://doi.org/10.5664/jcsm.8074
  • Costanzo, M. R., Khayat, R., Ponikowski, P., Augostini, R., Stellbrink, C., Mianulli, M., …Abraham, W. T. (2015). Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. Journal of the American College of Cardiology, 65(1), 72–84. https://doi.org/10.1016/j.jacc.2014.10.025
  • Drager, L. F., Santos, R. B., Silva, W. A., Parise, B. K., Giatti, S., Aielo, A. N., …Bensenor, I. M. (2019). OSA, short sleep duration, and their ınteractions with sleepiness and cardiometabolic risk factors in adults: The ELSA-Brasil study. Chest, 155(6), 1190–1198. https://doi.org/10.1016/j.chest.2018.12.003
  • Dursunoğlu, D. & Dursunoğlu, N.(2018). Cardiovascular diseases and sleep disordered breathing: what to do and what to watch? Turkiye Klinikleri J Cardiol-Special Topics,11,73-76.
  • Fietze, I., Laharnar, N., Obst, A., Ewert, R., Felix, S. B., Garcia, C., …Penzel, T. (2019). Prevalence and association analysis of obstructive sleep apnea with gender and age differences - Results of SHIP-Trend. Journal of Sleep Research, 28(5), e12770. https://doi.org/10.1111/jsr.12770
  • Huang, T., Lin, B. M., Markt, S. C., Stampfer, M. J., Laden, F., Hu, F. B., …Redline, S. (2018). Sex differences in the associations of obstructive sleep apnoea with epidemiological factors. The European Respiratory Journal, 51(3), 1702421. https://doi.org/10.1183/13993003.02421-2017
  • Kannel, W. B., McGee, D. & Gordon, T. (1976). A general cardiovascular risk profile: the Framingham Study. The American Journal of Cardiology, 38(1), 46–51. https://doi.org/10.1016/0002-9149(76)90061-8
  • Mehra R. (2019). Sleep apnea and the heart. Clevel and Clinic Journal of Medicine, 86(9 Suppl 1), 10–18. https://doi.org/10.3949/ccjm.86.s1.03
  • Meszaros, M., Tarnoki, A. D., Tarnoki, D. L., Kovacs, D. T., Forgo, B., Lee, …Bikov, A. (2020). Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study. Journal of Sleep Research, 29(4), e12979. https://doi.org/10.1111/jsr.12979
  • Mokhlesi, B., Temple, K. A., Tjaden, A. H., Edelstein, S. L., Nadeau, K. J., Hannon, T. S., …Van Cauter, E. (2019). The association of sleep disturbances with glycemia and obesity in youth at risk for or with recently diagnosed type 2 diabetes. Pediatric Diabetes, 20(8), 1056–1063. https://doi.org/10.1111/pedi.12917
  • Muñoz-Torres, Z., Jiménez-Correa, U. & Montes-Rodríguez, C. J. (2020). Sex differences in brain oscillatory activity during sleep and wakefulness in obstructive sleep apnea. Journal of Sleep Research, 29(4), e12977. https://doi.org/10.1111/jsr.12977
  • Obaseki, D. O., Kolawole, B. A., Gomerep, S. S., Obaseki, J. E., Abidoye, I. A., Ikem, R. T., …Erhabor, G. E. (2014). Prevalence and predictors of obstructive sleep apnea syndrome in a sample of patients with type 2 Diabetes Mellitus in Nigeria. Journal of the Nigeria Medical Association, 55(1), 24–28. https://doi.org/10.4103/0300-1652.128154
  • Oktay Arslan, B. & Ardıç, S. (2018). Obstructive sleep apnea syndrome and cardiometabolic consequences. Turkiye Klinikleri J Pulm Med-Special Topics, 11, 168-173.
  • Shah, N., Allison, M., Teng, Y., Wassertheil-Smoller, S., Sotres-Alvarez, D., Ramos, A. R., …Kaplan, R. C. (2015). Sleep apnea is independently associated with peripheral arterial disease in the Hispanic community health study/study of latinos. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(3), 710–715. https://doi.org/10.1161/ATVBAHA.114.304625
  • Ralls, F. & Cutchen, L. (2019). A contemporary review of obstructive sleep apnea. Current Opinion in Pulmonary Medicine, 25(6), 578–593. https://doi.org/10.1097/MCP.0000000000000623
  • Turkey Nutrition Guide. (TÜBER 2015). (2016). Turkish Republic Ministry of Health Publication. No, 1031, Ankara.
  • Umoh, V. A., Akpan, E. E., Ekrikpo, U. E., Idung, A. U. & Ekpe, E. E. (2020). The risk of obstructive sleep apnea among patients with type 2 diabetes mellitus. Journal of the Nigeria Medical Association, 61(1), 32–36. https://doi.org/10.4103/nmj.NMJ_129_19
  • Wali, S. O., Abalkhail, B. & Krayem, A. (2017). Prevalence and risk factors of obstructive sleep apnea syndrome in a Saudi Arabian population. Annals of Thoracic Medicine, 12(2), 88–94. https://doi.org/10.4103/1817-1737.203746
  • Wilson, P. W., D'Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H. & Kannel, W. B. (1998). Prediction of coronary heart disease using risk factor categories. Circulation, 97(18), 1837–1847. https://doi.org/10.1161/01.cir.97.18.1837
  • World Health Organisation (WHO 2020). In 20 September 2020 retrieved from://www.who.int/news-room/fact-sheets/detail/diabetes.
  • Viswanathan, V., Ramalingam, I. P. & Ramakrishnan, N. (2017). High prevalence of obstructive sleep apnea among people with type 2 diabetes mellitus in a tertiary care center. The Journal of the Association of Physicians of India, 65(11), 38–42.
  • Zhu, Z., Zhang, F., Liu, Y., Yang, S., Li, C., Niu, Q. & Niu, J. (2017). Relationship of obstructive sleep apnoea with diabetic retinopathy: A meta-analysis. Biomed Research International, 4737064. https://doi.org/10.1155/2017/4737064
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Serap Gökçe Eskin 0000-0002-8940-6116

Dide Kılıçalp Kılınç 0000-0003-3234-5911

Oğuzhan Oğuz 0000-0003-0761-2520

Erken Görünüm Tarihi 6 Haziran 2022
Yayımlanma Tarihi 20 Haziran 2022
Gönderilme Tarihi 28 Aralık 2021
Kabul Tarihi 18 Nisan 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 10 Sayı: 2

Kaynak Göster

APA Gökçe Eskin, S., Kılıçalp Kılınç, D., & Oğuz, O. (2022). OBSTRUCTIVE SLEEP APNEA AND CARDIOVASCULAR RISK FACTORS IN THE PATIENTS WITH TYPE 2 DIABETES MELLITUS. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, 10(2), 450-461. https://doi.org/10.33715/inonusaglik.1049837