Vitamin D and Its Metabolic Functions

Öz

Vitamin D is one of the most important vitamins for humankind and %95 of its requirements are acquired by synthesising solar rays on skin. While lack of vitamin D can lead to many diseases, especially cancer, the ones who get vitamin D in an appropriate level, can reduce this risk if they exercise. If, also, vitamin D level is high, obesity risk will be minimized because of eating less thanks to leptin hormone. Vitamin D receptors exist in approximately 40 tissues. The most imporant effect of vitamin D, which dissolves in fat, is on bone mineralization phosphorus metobolism and calcium. People whose vitamin D level is low, should take nourishment by sources rich in vitamin D instead of helper pills.

Anahtar Kelimeler

• Vitamin D, Energy, Energy Metabolism, Leptin, Obesity, Exercise

Vitamin D ve Metabolik Fonksiyonları

Öz

Vitamin D,insanoğlu için en önemli vitaminlerden biridir ve ihtiyacının %95’i güneş ışınlarının cilde sentezlenmesiyle karşılanır.Vitamin D eksikliği özellikle kanser gibi bir çok hastalığa yol açabileceği için,yeterli bir seviyede vitamin D alanlar eğer egzersiz yaparlarsa bu riski azaltabilirler.Aynı zamanda vitamin D seviyesi yüksek olursa,leptin hormonu sayesinde daha az yemek yeneceği için obezite riski minimuma inecektir.Vitamin D reseptörleri yaklaşık olarak 40 dokuda vardır.Yağda çözünen vitamin D’nin en önemli etkisi kemik minerilizasyonu fosfor metabolizması ve kalsiyum üzerinedir.Vitamin D seviyesi düşük olan kişiler,yardımcı ilaçlar yerine vitamin D açısından zengin olan kaynakların besinlerinden sendromlar,bulaşıcı,otoimmün ve kardiyovasküler gibi bir çok hastalıkla ilişkisi olduğu bildirilmiştir.Gözlemsel çalışmalarda,endüstrileşmiş ülkeler de dahil olmak üzere dünyanın kuzey bölgelerinde vitamin D eksikliğinin çok yaygın olduğu anlaşılmıştır

Anahtar Kelimeler

• Vitamin D, Enerji Metabolizması, Leptin, Obezite, Egzersiz

Kaynakça

1. Akman AO, Tumer L, Hasanoglu A, Ilhan M, Caycı B.(2011): Frequency of vitamin D insufficiency in healthy children between 1 and 16 years of age in Turkey. Pediatr Int; 53: 968-973.
2. Arslanoğlu İ. (2009). Çocuk ve ergenlerde şişmanlık sorunu ve yaklaşım. Türk Pediatri Arşivi;44:115-9.
3. Block SR.(2004). Vitamin D deficiency is not associated with nonspesific musculoskeletal pain syndromes including fibromyalgia. Mayo Clin Proc;79:1585-6.
4. Braun-Moscovici Y, Toledano K, Markovits D, Rozin A, Nahir AM, Balbir-Gurman A. Vitamin D level: is it related to disease activity in inflammatory joint disease? Rheumatol Int 2011; 31: 493-499.
5. Bringhurst FR, Demay MB, Krane SM, Kronenberg HM, (2005). Bone and Mineral Metabolism in Health and Disease. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Internal Medicine. 16th edition. New York:MCGraw-Hill Companies, p. 2238-86.
6. De Luca HF, Cantorna MT. (2001).Vitamin D: its role and uses in immunology. FASEB J;15:2579-2585.
7. De Torrente de Jara G, Pecoud A, Favrat B.(2004). Musculoskeletal pain in female asylium seekers and hypovitaminosis D3. BMJ;329:156-7
8. Devaraj S, Jialal G, Cook T, et al. Low vitamin D levels in Northern American adults with the metabolic syn- drome. Horm Metab Res 2011;43:72-74.

9. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ.(2004). Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med; 158: 531-537.
10. Fleck A. (1989). Latitude and ischaemic heart disease. Lancet:1:613.
11. Hatun Ş, Bereket A, Çalıkoğlu AS, Özkan B. (2003). Günümüzde D vitamini yetersizliği ve nütrisyonel rikets. Çocuk Sağlığı ve Hastalıkları Dergisi; 46: 224-241.
12. Harris S.(2002). Can vitamin D supplementation in infancy prevent type 1 diabetes? Nutr Rev;60:118-21.
13. Holick MF. (2002). Too little vitamin D in premenopausal women: why should we care?. Am J Clin Nutr, 76:3–4
14. Holick MF.( 2003). Vitamin D Deficiency: What a pain it is?. Mayo Clin Proc;78:1457-9.
15. Holick MF. (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr, 80:1678-88.
16. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM.(2001). Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet;358:1500-3.
17. Javorsky BR, Maybee N, Padia SH, Dalkin AC. (2006). Vitamin D deficiency in gastrointestinal disease. Pract Gastroenterol; 36:52-72.
18. Malabanan A, Veronikis IE, Holick MF. (1998). Redefining vitamin D insufficiency. Lancet;351:805–806
19. McGill AT, Stewart JM, Lithander FE, Strik CM, Poppitt SD. (2008). Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome overweight and obesity. Nutr J;7:4.
20. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. (2008). Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122: 398-417.
21. Muszkat P, Camargo MB, Griz LH, (2010). Lazaretti-Castro M. Evidence-based non-skeletal actions of vitamin D. Arq Bras Endocrinol Metabol, 54:110-117.
22. Narvaez, C. J., Matthews, D., Broun, E., Chan, M., & Welsh, J. (2009). Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology, 150(2), 651-661.
23. Nemere I, Carson F. (1998). Membrane receptors for steroid hormones: a case for spesific cell surface binding sites for vitamin D metabolites and estrogens. Bio- chem Biophys Res Com;248:442-449.
24. O’Connell TD, Berry JE, Jarvis AK, et al. 1,25-dihy- droxyvitamin D3 regulation of cardiac myocyte prolifer- ation and hypertrophy. Am J Physiol 1997;272:H1751- H1758.
25. Özkan B, Döneray H.(2011). D vitamininin iskelet sistemi dışı etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi;54:99-119.
26. Patel S, Farragher T, Berry J, Bunn D, Silman A, Symmons D. Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis Rheum 2007; 56: 2143-2149.
27. Pfeifer, M., Begerow, B., Minne, H. W., Suppan, K., Fahrleitner-Pammer, A., & Dobnig, H. (2009). Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporosis International, 20(2), 315-322.
28. Pelajo CF, Lopez-Benitez JM, Miller LC.(2010). Vitamin D and autoimmune rheumatologic disorders. Autoimmun Rev; 9: 507-510.
29. Reginato AJ, Falasca GF, Pappu R, McKnight B, (1999). Agha A Musculoskeletal manifestation of osteomalacia: report of 26 cases and literature review. Semin Artritis Rheum, 28:287-304.
30. Rosen CJ, Adams JS, Bikle DD, et al. The Nonskel- etal effects of Vitamin D: an Endocrine Society Scien- tific Statement. Endocrine Reviews 2012;33:456-492.
31. Rossini M, Maddali Bongi S, La Montagna G, et al. Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther 2010; 12: R216.
32. Schwartz MW, Woods SC, Porte D, Jr., Seeley RJ & Baskin DG (2000). Central nervous system control of food intake. Nature 404 661-671.
33. Snijder, M. B., van Dam, R. M., Visser, M., Deeg, D. J., Dekker, J. M., Bouter, L. M., ... & Lips, P. (2005). Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. The Journal of Clinical Endocrinology & Metabolism, 90(7), 4119-4123.
34. Thomas MK, Lloyd-Jones DM, Thadhani RI, (1998). Hypovitaminosis D in medical inpatients. N EnglJ Med.;338:777–83.
35. Zemel, M. B., Reddy, S., & Sowers, J. R. (1991). Insulin Attenuation of Vasoconstrictor Responses to Phenylephrine in Zucker Lean ana Obese Rats.American journal of hypertension, 4(6), 537-539.