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A General Aspect of Platelet Rich Plasma

Yıl 2015, Cilt 3, Sayı Special Issue 4, 494 - 502, 15.09.2015
https://doi.org/10.14486/IJSCS420

Öz

The aim of this scientific paper is to introduce Platelet Rich Plasma (PRP) cure method by people who never heard about it. People can hurt their selves, thus they can have damaged tissue; for instance broken bone, a scar or a wounded area. Furthermore damaged tissue can be a cartilage tissue, which takes very long time to heal. Platelets, those exist in the veins as thrombus, come up to repair those damaged tissues. However, platelets would be insufficient to cure damaged area in a short time. At this point PRP cure method give a hand to the healing process. By centrifuging people’s own blood via special kits, platelets can be separated from blood cells as plasma. That plasma’s platelet density is 3-5 times greater than that blood’s platelet density. Afterwards PRP method is implemented by injection of plasma to the damaged area or tissue. After implementation of 2-4 sessions per week, damaged tissue can be regenerated. It is fast healing method because densified platelet plasma is used; and it is safe because that plasma is obtained from people’s own blood. PRP can be implemented on many areas; for instance on dentistry, sports medicine, different kind of surgeries such as plastic, vascular or orthopedic and so on. When soccer players brake their legs, their sports life come to the end, but what if their broken legs was healed better and faster than general healing process? To sum up, PRP is very safe and the future of healing process.

Kaynakça

  • Anthony, P., Sclafani, M.D., (2009). Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial PlastSurg, 25:270–276.
  • Aspenberg, P., Virchenko, O., (2004). Platelet concentrate injection improves Achilles tendon repair in rats. ActaOrthop Scand.;75(1):93–9.
  • Azzena, B., Mazzoleni, F., Abatangelo, G. et al., (2008).Autologous platelet-rich plasma as an adipocyte in vivo delivery system:case report . Aesthetic PlastSurg, 32:155-8.
  • Bernstein, E.F., Chen, Y.Q,, Kopp, J.B. et al., (1996). Long-term sun exposure alters the collagen of the papillary dermis. Comparison of sun-protected and aged skin by northern analysis, immunohistochemical staining, and confocal laser scanning microscopy. J Am AcadDermatol, 34:209-218.
  • Bhanot, S., Alex, J.C., (2002). Current applications of platelet gels in facial plastic surgery. Facial PlastSurg,18: 27-33.
  • Carlson, N.E., Roach, R.B., (2002). Platelet – Rich Plasma: Clinical Applications in Dentistry. JADA. 133 October : 1383 – 1386.
  • Cho, M-II., Lin, W.N., Genco, R.J., (1995). Platelet Derived Growth Factor–Modulated Guided Tissue Regenerative Therapy. J. Periodontal 66 : 522 -530.
  • CKakudo, N., Minakata, T., Mitsui, T., et al., (2008). Proliferation-promoting effect of platelet rich plasma on human adipose-derived stem cells and human dermal fibroblasts. PlastReconstrSurg, 122:1352-1360.
  • Crovetti, G., Martinelli, G., Issi, M., et al., (2004). Platelet gel for healing cutaneous chronic wounds. Tranfusion and Apheresis Sci, 30:145-151.
  • Crovetti, G., Martinelli, G., Issi, M., Barone, M., et al., (2005). Autologous platelet gel applications during cardiovascular surgery: effect on wound healing. J Extra CorporTechnol, 37:148-52.
  • Doha, D.M., Choukroun, J., Diss, A., et al. (2006). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part: tehnological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral RadiolEndod., 101: 37-44.
  • Burd, A., Zhu, N., Poon, V.K., (2005). A study of Q-switched Nd: YAG laser irradiation and paracrine function in human skin cells. Dermatol immunol med., 21:131-7.
  • Englert, S.J., Estep, T.H., Ellis-Stoll, C.C., (2005). Autologous platelet gel applications during cardiovascular surgery: effect on wound healing. J Extra Corpor Technol, 37:148-52.
  • Eppley, B.L., Woodell, J.E., Higgins, J., (2004). Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast. Reconstr. Surg, 114:1502-1508.
  • Eppley, B.L., Pietrzak, W.S., Blanton, M., (2006). Platelet- rich plasma:a review of biology and applications in plastic surgery. PlastReconstrSurg, 118:147-159.
  • Fitzpatrick, R.E., Rostan, E.F., (2003). Reversal of damage with topical growth factors: a pilot study. J Cosmet Laser Ther, 5:25-34.
  • Freymiller, E.G., Aghaloo, T.L., (2004). Platelet-Rich Plasma: Ready or Not? J Oral Maxillofac Surg. 62 : 484 – 488.
  • Gonshor, A., (2002). Technique for producing platelet-rich plasma and platelet concentrate :background and process. Int J Periodontics Restorative Dent, 22:547-57.
  • Hanna, R., Trejo, P.M., Weltman, R.L., (2004). Treatment of intrabony defects with bovine-derived xenograft alone and in combination with platelet-rich plasma: a randomized clinical trial. J Periodontol, 75:1668-77.
  • Jeong, K.H., Shin, M.K., Kim, N., (2011). Refractory lipodermatosclerosis treated with intralesional platelet-rich plasma. J Am AcadDermatol. 2011.06.040
  • Kazemi, M., Azma, K., Tavana, B. et al., (2010). Autologous blood versus corticosteroid local injection in the short-term treatment of lateral elbow tendinopathy: a randomized clinical trial of efficacy. Am J PhysRehabil., 89(8), 660- 667, 0894-9115
  • Kim, D.H., Je, Y.J., Kim, C.D. et al.(2011). Can platelet- rich plasma be used for skin rejuvenation?EEvaluation of effects of platelet- rich plasma on human dermal fibroblast. Ann Dermatol, 23:424-431.
  • Knighton, D.R., Doucette, M., Fiegel, V.D.et al. (1988). The use of platelet derived wound healing formula in human clinical trials. ProgClinBiol Res, 266:319-29.
  • Korobelnik, J.F., Hannouche, D., Belayachi, N.et al. (1996). Autologous platelet concentrate as an adjunct in macular hole healing: a pilot study. Ophthalmology, 103:590-4.
  • Lee, J.W., Kim, B.J., Kim, M.N.et al. (2011). The Efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: A simultaneous split-face trial. DermatolSurg, 37:931–938.
  • Lemperle, G., Holmes, R.E., Cohen, S.R. et al., (2001). A classification of facial wrinkles.PlastReconstrSurg, 108:1735-1750.
  • Lind, M., (1996). Growth Factors: Possible New Clinical Tools. A review. Acta. Orthop. Scand. 67(4); 407–417.
  • Lynch, S.E., Trippel, S.B., Finkelman, R.D. et al., (1994). The combination of platelet-derived growth factor-BB and insulin-like growth factor-I stimulates bone repair in adult Yucatan miniature pigs. Wound Repair Regen., Jul;2(3):182-90.
  • Lyras, D., Kazakos, K., Verettas, D.et al., (2010). Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect, International Orthopaedics (SICOT), 34:143–148.
  • Man, D., Plosker, H., Winland-Brown, J.E., (2001). The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. PlastReconstr Surg., Jan;107(1):229-37
  • Marx, R.E., Carlson, E.R., Eichstaedt, R.M. et al., (1998). Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral RadiolEndod, 85:638-646.
  • Marx, R.E. (1999). Platelet Rich Plasma: A Source of Multiple Autologous Growth Factors for Bone Grafts . Tissue Engineering. Quietesence Publ. Chapter 4 p:71 – 82.
  • Marx, R.E. (2004). Platelet Rich Plasma: Evidence to Support its Use. J. Oral Maxillofacial Surg. 62: 489 – 496.
  • Mifune, Y., Matsumoto, T., Takayama, K.et al., (2012). The effect of platelet-rich plasma on the reenerative therapy of muscle derived stem cells for articular cartilage repair. Osteoarthritis Cartilage. doi:pii: S1063-4584(12)00993-4. 10.1016/j.joca.2012.09.018.
  • Na, J.I., Choi, J.W., Choi, H.R.et al., (2011). Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. DermatolSurg, 37:463–468.
  • Pietrzak, W.S., Eppley, B.L., (2005). Platelet rich plasma: biology and new technology. J Craniofac Surg., Nov;16(6):1043-54.
  • Powell, D.M., Chang, E., Farrior, E.H., (2001). Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial PlastSurg, 3:245-50.
  • Redaelli, A., Romano, D., Marciano, A., (2010). Face and neck revitalization with platelet –rich plasma (PRP):clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol, 9:466-472.
  • Robiony, M., Polini, F., Costa, F.et al., (2002). Osteogenesis distraction and platelet- rich plasma for bone restoration of the severely atrophic mandible:Preliminary results. J Oral Maxillofac Surg., 60: 630-635.
  • Sampson, S., et. al., (2008). Platelet rich plasma injection grafts form usculo skeletal injuries: a review. CurrRevMusculoskeletalMed.. Dec; 1(3-4): 165-74.
  • Savarino, L., Cenni, E., Tarabusi, C.et al., (2006). Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibialosteo to my forge nuvarus. J Biomed Mater Res B ApplBiomater, 76:364-72.
  • Sclafani, A.P., (2010). Platelet-rich fibrin matrix for improvement of deep nasolabial folds. JCosmetDermatol, 9:66-71
  • Takikawa, M., Nakamura, S., Nakamura, S., et al., (2011). Enhancedeffect of platelet-richplasmacontaining a newcarrier on hairgrowth. DermatolSurg, 37:1721–1729.
  • Tamariz-Dominque, E., Castro-Munozledo, F., Kuri-Harcuch, W., (2002). Growth factors and extra cellular matrix proteins during wound healing promoted with frozen cultured sheets of human epidermal keratinocytes. Cell Tissue Res, 307:79-89.
  • Trippel, S.B., Finkelman, R.D., Hernandez, R.A. et al., (1994). The combination of platelet-derived growth factor-BB and insulin-like growth factor-I stimulates bone repair in adult Yucatan miniature pigs. WoundRepair Regen., Jul;2(3):182-90.
  • Weibrich, G., Hansen, T., Kleis, W. et al., (2004). Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone, 34:665-671
  • Whitman, D.H., Berry, R.L., Green, D.M., (1997). Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofacial Surg., Nov;55(11):1294-9.
  • Wrotniak, M., Bielecki, T.,Gazdzik, T.S., (2007). Current opinion about using the platelet-rich gel in orthopedics and trauma surgery. OrtopTraumatolRehabil, 9: 227-38.
  • Zimmermann, R., Jakubietz, R., Strasser, E. et al., (2001). Different preparation methods to obtain platelet component as a source of growth factors for local application Transfusion, 4:1217-1224.

Trombosit Yönünden Zenginleştirilmiş Plazmaya Genel Bir Bakış

Yıl 2015, Cilt 3, Sayı Special Issue 4, 494 - 502, 15.09.2015
https://doi.org/10.14486/IJSCS420

Öz

Bu bilimsel makalenin amacı, trombosit yönünden zenginleştirilmiş plazma (PRP, Platelet Rich Plasma) ile tedavi yöntemini daha önce hiç duymamış insanlara tanıtmaktır. İnsanlar sakatlanabilir, böylece bedenlerinde doku zedelenmeleri yaşanabilir; örneğin kemik kırığı, küçük yaralanma ya da yaralı bir bölge oluşabilir. Ayrıca hasarlı doku iyileşmesi çok uzun zaman alan bir kıkırdak doku olabilir. Damarda trombüs olarak bulunan trombositler, hasarlı dokularını onarmak için ortaya çıkarlar. Bununla birlikte, kısa bir sürede trombositler hasarlı alanın tedavisi için yeterli olacaklardır. Bu noktada PRP tedavi yöntemi iyileşme sürecine bir el verir. Özel kitlerle santrifüj edilen insanların kanlarında trombosit, kan hücreleri ve plazmadan ayrıştırılabilir. Bu ayrıştırılmış plazmanın trombosit yoğunluğu, kandaki trombosit yoğunluğundan 3-5 kat daha fazladır. Daha sonra hasarlı bölgeye ya da dokuya plazma enjeksiyonu ile PRP yöntemi uygulanır. Haftada 2-4 seans uygulanması sonrasında, hasarlı doku yenilenebilir. Yoğunlaştırılmış trombosit plazması kullanıldığı için bu hızlı bir iyileşme yöntemidir; bu plazma insanın kendi kanından elde edildiği için de güvenli bir yöntemdir. PRP birçok alanda uygulanabilir; diş hekimliği, spor hekimliği ile plastik, damar ya da ortopedik gibi farklı tür cerrahi alanları örnek gösterilebilir. Futbolcuların bacakları kırıldığında spor hayatlarının sonuna gelirlerdi. Eğer kırılan bacakları daha iyi ve daha hızlı iyileştirilmiş olsaydı spor hayatları yine de biter miydi? Özetle PRP’ yi, geleceğin güvenli tedavi yöntemi olarak tanımlayabiliriz

Kaynakça

  • Anthony, P., Sclafani, M.D., (2009). Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial PlastSurg, 25:270–276.
  • Aspenberg, P., Virchenko, O., (2004). Platelet concentrate injection improves Achilles tendon repair in rats. ActaOrthop Scand.;75(1):93–9.
  • Azzena, B., Mazzoleni, F., Abatangelo, G. et al., (2008).Autologous platelet-rich plasma as an adipocyte in vivo delivery system:case report . Aesthetic PlastSurg, 32:155-8.
  • Bernstein, E.F., Chen, Y.Q,, Kopp, J.B. et al., (1996). Long-term sun exposure alters the collagen of the papillary dermis. Comparison of sun-protected and aged skin by northern analysis, immunohistochemical staining, and confocal laser scanning microscopy. J Am AcadDermatol, 34:209-218.
  • Bhanot, S., Alex, J.C., (2002). Current applications of platelet gels in facial plastic surgery. Facial PlastSurg,18: 27-33.
  • Carlson, N.E., Roach, R.B., (2002). Platelet – Rich Plasma: Clinical Applications in Dentistry. JADA. 133 October : 1383 – 1386.
  • Cho, M-II., Lin, W.N., Genco, R.J., (1995). Platelet Derived Growth Factor–Modulated Guided Tissue Regenerative Therapy. J. Periodontal 66 : 522 -530.
  • CKakudo, N., Minakata, T., Mitsui, T., et al., (2008). Proliferation-promoting effect of platelet rich plasma on human adipose-derived stem cells and human dermal fibroblasts. PlastReconstrSurg, 122:1352-1360.
  • Crovetti, G., Martinelli, G., Issi, M., et al., (2004). Platelet gel for healing cutaneous chronic wounds. Tranfusion and Apheresis Sci, 30:145-151.
  • Crovetti, G., Martinelli, G., Issi, M., Barone, M., et al., (2005). Autologous platelet gel applications during cardiovascular surgery: effect on wound healing. J Extra CorporTechnol, 37:148-52.
  • Doha, D.M., Choukroun, J., Diss, A., et al. (2006). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part: tehnological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral RadiolEndod., 101: 37-44.
  • Burd, A., Zhu, N., Poon, V.K., (2005). A study of Q-switched Nd: YAG laser irradiation and paracrine function in human skin cells. Dermatol immunol med., 21:131-7.
  • Englert, S.J., Estep, T.H., Ellis-Stoll, C.C., (2005). Autologous platelet gel applications during cardiovascular surgery: effect on wound healing. J Extra Corpor Technol, 37:148-52.
  • Eppley, B.L., Woodell, J.E., Higgins, J., (2004). Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast. Reconstr. Surg, 114:1502-1508.
  • Eppley, B.L., Pietrzak, W.S., Blanton, M., (2006). Platelet- rich plasma:a review of biology and applications in plastic surgery. PlastReconstrSurg, 118:147-159.
  • Fitzpatrick, R.E., Rostan, E.F., (2003). Reversal of damage with topical growth factors: a pilot study. J Cosmet Laser Ther, 5:25-34.
  • Freymiller, E.G., Aghaloo, T.L., (2004). Platelet-Rich Plasma: Ready or Not? J Oral Maxillofac Surg. 62 : 484 – 488.
  • Gonshor, A., (2002). Technique for producing platelet-rich plasma and platelet concentrate :background and process. Int J Periodontics Restorative Dent, 22:547-57.
  • Hanna, R., Trejo, P.M., Weltman, R.L., (2004). Treatment of intrabony defects with bovine-derived xenograft alone and in combination with platelet-rich plasma: a randomized clinical trial. J Periodontol, 75:1668-77.
  • Jeong, K.H., Shin, M.K., Kim, N., (2011). Refractory lipodermatosclerosis treated with intralesional platelet-rich plasma. J Am AcadDermatol. 2011.06.040
  • Kazemi, M., Azma, K., Tavana, B. et al., (2010). Autologous blood versus corticosteroid local injection in the short-term treatment of lateral elbow tendinopathy: a randomized clinical trial of efficacy. Am J PhysRehabil., 89(8), 660- 667, 0894-9115
  • Kim, D.H., Je, Y.J., Kim, C.D. et al.(2011). Can platelet- rich plasma be used for skin rejuvenation?EEvaluation of effects of platelet- rich plasma on human dermal fibroblast. Ann Dermatol, 23:424-431.
  • Knighton, D.R., Doucette, M., Fiegel, V.D.et al. (1988). The use of platelet derived wound healing formula in human clinical trials. ProgClinBiol Res, 266:319-29.
  • Korobelnik, J.F., Hannouche, D., Belayachi, N.et al. (1996). Autologous platelet concentrate as an adjunct in macular hole healing: a pilot study. Ophthalmology, 103:590-4.
  • Lee, J.W., Kim, B.J., Kim, M.N.et al. (2011). The Efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: A simultaneous split-face trial. DermatolSurg, 37:931–938.
  • Lemperle, G., Holmes, R.E., Cohen, S.R. et al., (2001). A classification of facial wrinkles.PlastReconstrSurg, 108:1735-1750.
  • Lind, M., (1996). Growth Factors: Possible New Clinical Tools. A review. Acta. Orthop. Scand. 67(4); 407–417.
  • Lynch, S.E., Trippel, S.B., Finkelman, R.D. et al., (1994). The combination of platelet-derived growth factor-BB and insulin-like growth factor-I stimulates bone repair in adult Yucatan miniature pigs. Wound Repair Regen., Jul;2(3):182-90.
  • Lyras, D., Kazakos, K., Verettas, D.et al., (2010). Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect, International Orthopaedics (SICOT), 34:143–148.
  • Man, D., Plosker, H., Winland-Brown, J.E., (2001). The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. PlastReconstr Surg., Jan;107(1):229-37
  • Marx, R.E., Carlson, E.R., Eichstaedt, R.M. et al., (1998). Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral RadiolEndod, 85:638-646.
  • Marx, R.E. (1999). Platelet Rich Plasma: A Source of Multiple Autologous Growth Factors for Bone Grafts . Tissue Engineering. Quietesence Publ. Chapter 4 p:71 – 82.
  • Marx, R.E. (2004). Platelet Rich Plasma: Evidence to Support its Use. J. Oral Maxillofacial Surg. 62: 489 – 496.
  • Mifune, Y., Matsumoto, T., Takayama, K.et al., (2012). The effect of platelet-rich plasma on the reenerative therapy of muscle derived stem cells for articular cartilage repair. Osteoarthritis Cartilage. doi:pii: S1063-4584(12)00993-4. 10.1016/j.joca.2012.09.018.
  • Na, J.I., Choi, J.W., Choi, H.R.et al., (2011). Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. DermatolSurg, 37:463–468.
  • Pietrzak, W.S., Eppley, B.L., (2005). Platelet rich plasma: biology and new technology. J Craniofac Surg., Nov;16(6):1043-54.
  • Powell, D.M., Chang, E., Farrior, E.H., (2001). Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial PlastSurg, 3:245-50.
  • Redaelli, A., Romano, D., Marciano, A., (2010). Face and neck revitalization with platelet –rich plasma (PRP):clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol, 9:466-472.
  • Robiony, M., Polini, F., Costa, F.et al., (2002). Osteogenesis distraction and platelet- rich plasma for bone restoration of the severely atrophic mandible:Preliminary results. J Oral Maxillofac Surg., 60: 630-635.
  • Sampson, S., et. al., (2008). Platelet rich plasma injection grafts form usculo skeletal injuries: a review. CurrRevMusculoskeletalMed.. Dec; 1(3-4): 165-74.
  • Savarino, L., Cenni, E., Tarabusi, C.et al., (2006). Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibialosteo to my forge nuvarus. J Biomed Mater Res B ApplBiomater, 76:364-72.
  • Sclafani, A.P., (2010). Platelet-rich fibrin matrix for improvement of deep nasolabial folds. JCosmetDermatol, 9:66-71
  • Takikawa, M., Nakamura, S., Nakamura, S., et al., (2011). Enhancedeffect of platelet-richplasmacontaining a newcarrier on hairgrowth. DermatolSurg, 37:1721–1729.
  • Tamariz-Dominque, E., Castro-Munozledo, F., Kuri-Harcuch, W., (2002). Growth factors and extra cellular matrix proteins during wound healing promoted with frozen cultured sheets of human epidermal keratinocytes. Cell Tissue Res, 307:79-89.
  • Trippel, S.B., Finkelman, R.D., Hernandez, R.A. et al., (1994). The combination of platelet-derived growth factor-BB and insulin-like growth factor-I stimulates bone repair in adult Yucatan miniature pigs. WoundRepair Regen., Jul;2(3):182-90.
  • Weibrich, G., Hansen, T., Kleis, W. et al., (2004). Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone, 34:665-671
  • Whitman, D.H., Berry, R.L., Green, D.M., (1997). Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofacial Surg., Nov;55(11):1294-9.
  • Wrotniak, M., Bielecki, T.,Gazdzik, T.S., (2007). Current opinion about using the platelet-rich gel in orthopedics and trauma surgery. OrtopTraumatolRehabil, 9: 227-38.
  • Zimmermann, R., Jakubietz, R., Strasser, E. et al., (2001). Different preparation methods to obtain platelet component as a source of growth factors for local application Transfusion, 4:1217-1224.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Onur ORAL>

0000-0001-9117-6359


Athanasios PAPAVASILIOU Bu kişi benim


Refik CABUK Bu kişi benim


George NOMIKOS Bu kişi benim


Yeliz OZVEREN Bu kişi benim


S. Rana VAROL Bu kişi benim

Yayımlanma Tarihi 15 Eylül 2015
Yayınlandığı Sayı Yıl 2015, Cilt 3, Sayı Special Issue 4

Kaynak Göster

Bibtex @ { intjscs108360, journal = {International Journal of Sport Culture and Science}, issn = {2148-1148}, address = {}, publisher = {Uluslararası Bilim Kültür ve Spor Derneği (UBİKS)}, year = {2015}, volume = {3}, number = {Special Issue 4}, pages = {494 - 502}, doi = {10.14486/IJSCS420}, title = {A General Aspect of Platelet Rich Plasma}, key = {cite}, author = {Oral, Onur and Papavasılıou, Athanasios and Cabuk, Refik and Nomıkos, George and Ozveren, Yeliz and Varol, S. Rana} }
APA Oral, O. , Papavasılıou, A. , Cabuk, R. , Nomıkos, G. , Ozveren, Y. & Varol, S. R. (2015). A General Aspect of Platelet Rich Plasma . International Journal of Sport Culture and Science , Cilt 3 (Özel Sayı 2) , 494-502 . DOI: 10.14486/IJSCS420
MLA Oral, O. , Papavasılıou, A. , Cabuk, R. , Nomıkos, G. , Ozveren, Y. , Varol, S. R. "A General Aspect of Platelet Rich Plasma" . International Journal of Sport Culture and Science 3 (2015 ): 494-502 <https://dergipark.org.tr/tr/pub/intjscs/issue/8670/108360>
Chicago Oral, O. , Papavasılıou, A. , Cabuk, R. , Nomıkos, G. , Ozveren, Y. , Varol, S. R. "A General Aspect of Platelet Rich Plasma". International Journal of Sport Culture and Science 3 (2015 ): 494-502
RIS TY - JOUR T1 - Trombosit Yönünden Zenginleştirilmiş Plazmaya Genel Bir Bakış AU - OnurOral, AthanasiosPapavasılıou, RefikCabuk, GeorgeNomıkos, YelizOzveren, S. RanaVarol Y1 - 2015 PY - 2015 N1 - doi: 10.14486/IJSCS420 DO - 10.14486/IJSCS420 T2 - International Journal of Sport Culture and Science JF - Journal JO - JOR SP - 494 EP - 502 VL - 3 IS - Special Issue 4 SN - 2148-1148- M3 - doi: 10.14486/IJSCS420 UR - https://doi.org/10.14486/IJSCS420 Y2 - 2023 ER -
EndNote %0 International Journal of Sport Culture and Science A General Aspect of Platelet Rich Plasma %A Onur Oral , Athanasios Papavasılıou , Refik Cabuk , George Nomıkos , Yeliz Ozveren , S. Rana Varol %T A General Aspect of Platelet Rich Plasma %D 2015 %J International Journal of Sport Culture and Science %P 2148-1148- %V 3 %N Special Issue 4 %R doi: 10.14486/IJSCS420 %U 10.14486/IJSCS420
ISNAD Oral, Onur , Papavasılıou, Athanasios , Cabuk, Refik , Nomıkos, George , Ozveren, Yeliz , Varol, S. Rana . "A General Aspect of Platelet Rich Plasma". International Journal of Sport Culture and Science 3 / Special Issue 4 (Eylül 2015): 494-502 . https://doi.org/10.14486/IJSCS420
AMA Oral O. , Papavasılıou A. , Cabuk R. , Nomıkos G. , Ozveren Y. , Varol S. R. A General Aspect of Platelet Rich Plasma. IntJSCS. 2015; 3(Special Issue 4): 494-502.
Vancouver Oral O. , Papavasılıou A. , Cabuk R. , Nomıkos G. , Ozveren Y. , Varol S. R. A General Aspect of Platelet Rich Plasma. International Journal of Sport Culture and Science. 2015; 3(Special Issue 4): 494-502.
IEEE O. Oral , A. Papavasılıou , R. Cabuk , G. Nomıkos , Y. Ozveren ve S. R. Varol , "A General Aspect of Platelet Rich Plasma", International Journal of Sport Culture and Science, c. 3, sayı. Special Issue 4, ss. 494-502, Eyl. 2015, doi:10.14486/IJSCS420
IntJSCS is published by International Science Culture and Sport Association (ISCSA).