THE RELATION OF SERUM NESFATIN-1 LEVELS WITH DISEASE SEVERITY AND COMPLICATIONS IN PATIENTS WITH LIVER CIRRHOSIS

Öz

Objective: Nesfatin-1 is an anorectic polypeptide that plays im portant roles in regulating appetite and energy intake. Cachexia and malnutrition are common in individuals with cirrhosis. We ex amined the relationship between serum nesfatin-1 levels and stage of cirrhosis, with the hypothesis that an increase in nesfatin-1 levels in patients with cirrhosis may be related to this catabolic process. Material and Method: The study includes 51 patients with cirrhosis and 30 healthy volunteers. Nesfatin-1 levels in serum samples were compared using the enzyme-linked immunosorbent assay (ELISA). We calculated the Child-Pugh stages and Model for End-Stage Liver Disease (MELD) scores of patients with cirrhosis and examined their relationship with nesfatin-1. We’ve also investigated the relationship between cirrhosis complications and nesfatin-1. Results: We found nesfatin-1 levels to be significantly higher in the cirrhosis patient group compared to the control group (p=0.001). The patient group was divided into those with compensated and those with decompensated liver cirrhosis and compared with the control group. Nesfatin-1 levels were found to be significantly higher in the compensated liver cirrhosis group (p=0.01). When classifying the patients with cirrhosis based on their Child-Pugh stages and MELD scores, no significant relationship was detected between these groups and their nesfatin-1 levels. Conclusion: Nesfatin-1 may have antioxidant, anti-inflammatory, and anti-apoptotic effects in maintaining the state of patients with compensated liver cirrhosis. Low levels of nesfatin-1 in decompensated liver cirrhosis may result from defense mecha nisms and inadequate production.

Anahtar Kelimeler

• Nesfatin-1
• liver
• cirrhosis
• decompensation
• anti-in f lammatory
• antioxidant

KARACİĞER SİROZLU HASTALARDA SERUM NESFATİN-1 DÜZEYLERİNİN HASTALIK ŞİDDETİ VE KOMPLİKASYONLARI İLE İLİŞKİSİ

Öz

Amaç: Nesfatin-1, iştahın ve enerji alımının düzenlenmesinde önemli rolleri olan anorektik bir polipeptittir. Kaşeksi ve malnut risyon sirozlu bireylerde yaygındır. Nesfatin-1 düzeylerinin siroz lu hastalardaki artışının sirozdaki katabolik süreçle alakalı olabi leceği hipoteziyle nesfatin-1 serum düzeyleri ve siroz aşamaları ilişkisini inceledik. Gereç ve Yöntem: Çalışmamıza 51 sirozlu hasta ve 30 sağlıklı gönüllü alındı. Serum örneklerinden nesfatin-1 düzeyleri ELISA kullanılarak karşılaştırıldı. Sirozlu hastaların Child-Pugh evreleri ve multifaktöriyel son dönem karaciğer hastalığı modeli (MELD) skorları hesaplanarak nesfatin-1 ile ilişkileri incelendi. Ek olarak siroz komplikasyonları ile nesfatin-1 arasındaki ilişki araştırıldı. Bulgular: Nesfatin-1 düzeyleri sirozlu hasta grubunda kontrol grubuna göre anlamlı olarak yüksek bulundu (p=0,001). Hasta grubu kompanse ve dekompanse olarak ayrılıp, kontrol grubu ile karşılaştırıldı. Kompanse siroz grubunda nesfatin-1 düzeyleri an lamlı olarak yüksek bulundu (p=0,01). Sirozlu hastalar Child-Pugh evrelerine ve MELD skorlarına göre sınıflandırıldığında bu gru plar ile nesfatin-1 düzeyleri arasında anlamlı bir ilişki saptanmadı. Sonuç: Sirozlu hastalarda kompanze halin sürdürülmesinde nes fatin-1’in antioksidan, antiinflamatuar ve antiapoptotik etkileri olabilir. Dekompanse sirozda nesfatin-1 düzeylerinin düşük olması savunma mekanizması ve yetersiz üretimden kaynaklanabilir.

Anahtar Kelimeler

• Nesfatin-1
• karaciğer
• siroz
• dekompansas yon
• antienflamatuvar
• antioksidan

Kaynakça

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