Diyabetes Mellitusta Fitoterapinin Etkisi

Muhammed Taha Kaya; Tolga Güvenç

doi:10.35229/jaes.1284154

EN TR

Effects of Phytotheraphy in Diabetes Mellitus

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by a persistent increase in blood glucose levels, causing various metabolic disorders. There are 2 main types of diabetes: Diabetes Mellitus Type 1 (insulin-dependent) and Diabetes Mellitus Type 2 (insulin-independent). Type 1 DM results from the inability to produce insulin as a result of epigenetic (autoimmunity / mutation) or acquired destruction of the β cells of the pancreas. T2DM is characterized by a prolonged increase in blood glucose levels due to a defect in insulin secretion or the insulin receptor. If diabetes is not treated well, it can affect various organs such as the heart, blood vessels, kidneys, brain and eyes, leading to various life-threatening complications and even death. Since there is no complete treatment for the disease, the applications are aimed at keeping blood glucose levels under control. However, the drugs applied may have different side effects. With this situation, medicinal plants with antihypoglycemic and antidiabetic potential have been used as supplements in diabetes. The aim of supportive treatment is to increase the effect of medical treatment, to reduce the effects of complications due to DM, and to increase the living standards of patients. The aim of this review is to compile the mechanisms of action of phytotherapeutic agents obtained from various medicinal plants on experimental animals and cell lines for which diabetes models were created.

Keywords

Diabetes Mellitus , Phytotherapy , Laboratory Animals

Diyabetes Mellitusta Fitoterapinin Etkisi

Öz

Diabetes mellitus (DM), kan glukoz seviyesinde kalıcı bir artışla karakterize, çeşitli metabolik bozukluğa neden olan kronik bir hastalıktır. Diyabetes Mellitus Tip 1(insüline bağımlı) ve Diyabetes Mellitus Tip 2 (insülinden bağımsız) olmak üzere 2 ana diyabet tipi bulunmaktadır. Tip 1 DM, pankreasın β hücrelerinin epigenetik (otoimmünite / mutasyon) veya edinsel olarak yok olması sonucunda insülin üretilememesinden kaynaklanmaktadır. T2DM, insülin sekresyonundaki veya insülin reseptöründeki defekt nedeniyle kan şekeri seviyesinde uzun süreli artış ile karakterizedir. Diyabet iyi tedavi edilmezse kalp, damar, böbrek, beyin, göz gibi çeşitli organları etkileyerek yaşamı tehdit eden çeşitli komplikasyonlara hatta ölüme yol açabilmektedir. Hastalığın tam bir tedavisi bulunmamakla yapılan uygulamalar kan glukoz seviyesini kontrol altında tutmaya yöneliktir. Ancak uygulanan ilaçların farklı yan etkileri bulunabilmektedir. Bu durumla beraber antihipoglisemik ve antidiyabetik potansiyeli olan medikal bitkiler diyabette destekleyici olarak kullanılmaya başlanmıştır. Destekleyici tedavinin amacı ise uygulanan medikal tedavinin etkisini artırmak, DM’ye bağlı oluşan komplikasyonların etkisini azaltmak ve hastaların yaşam standartlarını yükseltmektir. Bu derlemenin amacı, çeşitli medikal bitkilerden elde edilen fitoterapik ajanların diyabet modeli oluşturulan deney hayvanları ve hücre hatları üzerinde etki mekanizmalarının derlenmesidir.

Anahtar Kelimeler

Diyabetes Mellitus , Fitoterapi , Deney Hayvanları

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Muhammed Taha Kaya ^*
0000-0003-2744-4763
Türkiye

Tolga Güvenç
0000-0003-1468-3415
Türkiye

Erken Görünüm Tarihi

15 Eylül 2023

Yayımlanma Tarihi

30 Eylül 2023

Gönderilme Tarihi

16 Nisan 2023

Kabul Tarihi

28 Temmuz 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 8 Sayı: 3

DOI

https://doi.org/10.35229/jaes.1284154

IZ

https://izlik.org/JA54MM92MC

APA

Kaya, M. T., & Güvenç, T. (2023). Diyabetes Mellitusta Fitoterapinin Etkisi. Journal of Anatolian Environmental and Animal Sciences, 8(3), 265-272. https://doi.org/10.35229/jaes.1284154

JAES, 2016- 11.yıl

Effects of Phytotheraphy in Diabetes Mellitus

Abstract

Keywords

Diyabetes Mellitusta Fitoterapinin Etkisi

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster