Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü

Çağlar Adıgüzel; Hatice Karaboduk; Fatma Gökçe Apaydın; Yusuf Kalender

doi:10.35229/jaes.1754345

EN TR

Toxic Effect of Palladium Chloride on Blood and Spleen Tissue of Rats and Protective Role of Quercetin

Öz

Palladium is a heavy metal whose use in the industry has increased significantly in recent years, resulting in public health problems. Quercetin is a flavanol compound with antioxidant, anti-inflammatory and anticancer properties. In this study, the protective role of quercetin (Que) against the oxidative damage caused by palladium chloride (PdCl2) in the blood and spleen tissue of rats was investigated. Four groups were formed with 6 animals in each group. Control group, Que group (30 mg/kg bw), PdCl2 group (8 mg/kg bw) and Que+PdCl2 group. For 28 days, the administration substances were given to the rats by oral gavage. At the end of the experiment, there was a significant increase in the amount of MDA in the blood and spleen tissues of rats administered PdCl2 compared to the amount of MDA in the control group (p<0.05). At the same time, a significant decrease was observed in the SOD, CAT, GPx and GST antioxidant enzyme activities of rats in the PdCl2 group compared to the antioxidant enzyme activities of rats in the control group (p<0.05). When the quercetin-treated group was compared with the PdCl2-treated group, a significant increase in SOD, CAT, GPx and GST activities was reported, while the amount of MDA in blood and spleen tissues decreased. These results indicate that quercetin is an important food supplement.

Anahtar Kelimeler

Blood, Oxidative stress, Palladium chloride, Quercetin, Spleen

Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü

Öz

Paladyum son yıllarda endüstride kullanımı ciddi anlamda artan ve bunun sonucu olarak da halk sağlığı problemlerini meydana getiren bir ağır metaldir. Kuersetin antioksidan, anti-inflamatuar ve anti-kanser gibi özellikleri ile öne çıkan flavanol bir bileşiktir. Bu çalışmada paladyum klorürün (PdCl2) sıçanların kan ve dalak dokusunda yarattığı oksidatif hasara karşı kuersetinin (Que) korucu rolü araştırılmıştır. Her grupta 6 hayvan olacak şekilde 4 grup oluşturulmuştur. Kontrol grubu, Que grubu (30 mg/kg v.a.), PdCl2 grubu (8 mg/kg v.a.) ve Que+PdCl2 grubu. 28 gün boyunca uygulama maddeleri sıçanlara oral gavaj yoluyla verilmiştir. Deney sonunda PdCl2 uygulanan sıçanların kan ve dalak dokularındaki MDA miktarında kontrol grubundaki sıçanların MDA miktarına göre anlamlı bir artış meydana gelmiştir (p<0,05). Aynı zamanda PdCl2 grubundaki sıçanların SOD, CAT, GPx ve GST antioksidan enzim aktivitelerinde, kontrol grubundaki sıçanların antioksidan enzim aktivitelerine göre anlamlı bir azalma gözlenmiştir (p<0,05). Kuersetin uygulamalı grup ile PdCl2 uygulamalı grup karşılaştırıldığında kan ve dalak dokularındaki MDA miktarı azalırken, SOD, CAT, GPx ve GST aktivitelerinde anlamlı bir artış rapor edilmiştir. Bu sonuçlar kuersetinin önemli bir takviye gıda olduğunu göstermektedir.

Anahtar Kelimeler

Dalak, Kan, Kuersetin, Paladyum klorür, Oksidatif stres

Etik Beyan

Tüm deney prosedürleri için Gazi Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu tarafından onay alındı (G.Ü.ET-23.064).

Teşekkür

Çalışmamızın deney hayvanları kısmını maddi olarak destekleyen Gazi Üniversitesi Bilimsel Araştırma Projeleri birimine teşekkür ederiz

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Hayvan Fizyolojisi - Ekofizyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Çağlar Adıgüzel ^*
0000-0003-3716-0051
Türkiye

Hatice Karaboduk
0000-0001-6752-7219
Türkiye

Fatma Gökçe Apaydın
0000-0002-2771-7488
Türkiye

Yusuf Kalender
0000-0001-5457-0517
Türkiye

Erken Görünüm Tarihi

15 Kasım 2025

Yayımlanma Tarihi

30 Kasım 2025

Gönderilme Tarihi

31 Temmuz 2025

Kabul Tarihi

4 Kasım 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 10 Sayı: 6

DOI

https://doi.org/10.35229/jaes.1754345

IZ

https://izlik.org/JA72GR58EL

APA

Adıgüzel, Ç., Karaboduk, H., Apaydın, F. G., & Kalender, Y. (2025). Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü. Journal of Anatolian Environmental and Animal Sciences, 10(6), 876-882. https://doi.org/10.35229/jaes.1754345

AMA

1.Adıgüzel Ç, Karaboduk H, Apaydın FG, Kalender Y. Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü. Journal of Anatolian Environmental and Animal Sciences. 2025;10(6):876-882. doi:10.35229/jaes.1754345

Chicago

Adıgüzel, Çağlar, Hatice Karaboduk, Fatma Gökçe Apaydın, ve Yusuf Kalender. 2025. “Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü”. Journal of Anatolian Environmental and Animal Sciences 10 (6): 876-82. https://doi.org/10.35229/jaes.1754345.

EndNote

Adıgüzel Ç, Karaboduk H, Apaydın FG, Kalender Y (01 Kasım 2025) Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü. Journal of Anatolian Environmental and Animal Sciences 10 6 876–882.

IEEE

[1]Ç. Adıgüzel, H. Karaboduk, F. G. Apaydın, ve Y. Kalender, “Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü”, Journal of Anatolian Environmental and Animal Sciences, c. 10, sy 6, ss. 876–882, Kas. 2025, doi: 10.35229/jaes.1754345.

ISNAD

Adıgüzel, Çağlar - Karaboduk, Hatice - Apaydın, Fatma Gökçe - Kalender, Yusuf. “Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü”. Journal of Anatolian Environmental and Animal Sciences 10/6 (01 Kasım 2025): 876-882. https://doi.org/10.35229/jaes.1754345.

JAMA

1.Adıgüzel Ç, Karaboduk H, Apaydın FG, Kalender Y. Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü. Journal of Anatolian Environmental and Animal Sciences. 2025;10:876–882.

MLA

Adıgüzel, Çağlar, vd. “Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü”. Journal of Anatolian Environmental and Animal Sciences, c. 10, sy 6, Kasım 2025, ss. 876-82, doi:10.35229/jaes.1754345.

Vancouver

1.Çağlar Adıgüzel, Hatice Karaboduk, Fatma Gökçe Apaydın, Yusuf Kalender. Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü. Journal of Anatolian Environmental and Animal Sciences. 01 Kasım 2025;10(6):876-82. doi:10.35229/jaes.1754345

JAES, 2016- 11.yıl

Toxic Effect of Palladium Chloride on Blood and Spleen Tissue of Rats and Protective Role of Quercetin

Öz

Anahtar Kelimeler

Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü

Öz

Anahtar Kelimeler

Etik Beyan

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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