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Çocuklarda Trombositopeniye Yaklaşım

Yıl 2016, Cilt: 16 Sayı: 2, 67 - 73, 01.07.2016

Selime Aydoğdu Serap Karaman Zeynep Karakaş

https://doi.org/10.5222/j.child.2016.067

Öz

Trombositler primer hemostazda görevli ana elemanlardır. Trombosit sayısının 150.000/mm3’den düşük olmasına trombositopeni denir. Trombositopenik hastaya yaklaşımda detaylı öykü alınması, tam fizik muayene yapılması ve labo- ratuar değerlendirmede periferik yaymanın kesinlikle ince- lenmsi gerekir. Trombositlerin sayı ve morfolojisi, küme oluşturması, diğer kan elemanlarının sayısal ve morfolojik değerlendirlmesi için periferik yayma tanısal yaklaşımda altın standarttır

Anahtar Kelimeler

Çocuk trombositopeni periferik yayma

Kaynakça

  • Beyan C, nevruz o. Kanama ve tromboz (Çeviri). Harrison İç Hastalıkları Prensipleri (Çeviri). Çeviri Editörü: Yahya Sağlıker. Cilt 1, 15. Edisyon, Nobel Tıp Kitabevleri, 2004: 354-60.
  • McGuinn C, Bussel JB. Disorders of platelets. Lanzkowsky’s manual of pediatric hematology and oncology. Sixth Edition 2016;239-278.
  • https://doi.org/10.1016/B978-0-12-801368-7.00014-4
  • Kılınç Y. Trombositopenilerde tanısal yaklaşım (Algoritma). Türk Pediatrik Hematoloji Derneği, TPHD Eğitim Serisi-IV, Trombosit Hastalıkları. Galenos Yayıncılık, 2017;31-34.
  • Liu Y, Chen S, Sun Y, Lin Q, Liao X, Zhang J, et al. Clinical characteristics of immune thrombocytopenia associated with autoimmune disease: A retrospective study. Medicine (Baltimore) 2016;95:5565.
  • https://doi.org/10.1097/MD.0000000000005565
  • Choi SI, mcClure Pd. Idiopathic thrombocytopenic purpura in childhood. Can Med Assoc J 1967;97:562- 568.
  • Franchini m. The platelet-function analyzer (PFA– 100®) for evaluating primary hemostasis. Hematology 2005;10:177-81.
  • https://doi.org/10.1080/10245330400026097
  • drachman JG. Inherited thrombocytopenia: when a low platelet count does not mean ITP. Blood 2004;103:390-8.
  • https://doi.org/10.1182/blood-2003-05-1742
  • Wilon DB. Acquired platelet disorders. In Nathan and Oski’s Hematology of infancy and childhood. 7th edition. 2009;1553-1590 .
  • Albert mH, noterangelo Ld, occhs Hd. Clinical spectrum, pathophysiology and treatment of theWiskott- Aldrich syndrome. Curr Opin Hematol 2011;18:42-8.
  • https://doi.org/10.1097/MOH.0b013e32834114bc
  • Evans rS, Takahashi K, duane rT. Primary throm- bocytopenic purpura and acquired haemolytic anemia. Arch Int Med 1951;87:48-65.
  • https://doi.org/10.1001/archinte.1951.03810010058005
  • Aul C, Giagounidis A, et al. Evaluating the prognosis of patients with myelodysplastic syndromes. Review article. Ann Hematol 2002;81:485-97.
  • https://doi.org/10.1007/s00277-002-0530-z
  • nakao S, Ishiyama K. Hypomegakaryocytic throm- bocytopenia and increased number of PNH-phenotype cells-an emerging subgroup of myelodysplastic syndro- me showing frequent response to immunosuppression- Response to Refferr to Rafferty&Leach. Correspon- dence. Br J Haematol 2017; 14755.
  • https://doi.org/10.1111/bjh.14755
  • Bussel JB. Alloimmune thrombocytopenia in the fetus and newborn. Semin Thromb Hemos 2001;27:245-52.
  • https://doi.org/10.1055/s-2001-15254
  • roberts I, Stanworth S, murray nA. Thrombocyto- phenia in neonate. Blood Rev 2008;22:173-86.
  • https://doi.org/10.1016/j.blre.2008.03.004
  • WongW, Glader B. Approach to the newborn who has thrombocytophenia. Neo Reviews 2004;5:444-9.
  • https://doi.org/10.1542/neo.5-10-e444
  • murray nA, Howarth LJ, mcCloy mP, Letsky EA, roberts IA. Platelet transfusion in the management of severe thrombocytophenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41.
  • https://doi.org/10.1046/j.1365-3148.2002.00343.x
  • Bussel JB, Zacharoulis S, Kramer K, mcFarland JG, Pauliny J, Kaplan C. Clinical and diagnostic comparison of neonatal alloımmune thrombocytophe- nia to non-immun cases of thromboctrophenia. Pediatr Blood Cancer 2005;45:176-83.
  • https://doi.org/10.1002/pbc.20282
  • George r. Buchanan. Thrombocytopenia during child- hood: What the pediatrician needs to know? Pediatrics in Review 2005;26(11):401-9.
  • Audia S, rossato m, Santegoets K, Spijkers S, Wichers C, Bekker C, et al. Splenic TFH expansion partipipates in B-cell differentiation and antiplatelet antibody production during immune thrombocytophe- nia. Blood 2014;124:2858-86.
  • https://doi.org/10.1182/blood-2014-03-563445
  • Cox K, Price V, Kahr WH. Inherited platelet disor- ders: a clinical approach to diagnosis and management. Expert Rev Hematol 2011;4:455-72.
  • Stasi r. How to approach thrombocytophenia. ASH Education Program Book 2012;191-197.

Approach to Thrombocytophenia in Children

Yıl 2016, Cilt: 16 Sayı: 2, 67 - 73, 01.07.2016

Selime Aydoğdu Serap Karaman Zeynep Karakaş

https://doi.org/10.5222/j.child.2016.067

Öz

Platelets are the key elements that are responsible for pri- mary hemostasis. When absolute number of platelets in peripheral blood is less than 150000/mm3, it is called thrombocytopenia. Detailed anamnesis, complete physical examination and a laboratory evaluation including perip- heral blood smear are vital when approaching to throm- bocytopenic patients. Peripheral blood smear is the gold standard diagnostic approach for quantitative, and morp- hological evaluation of number, morphology and clustering of platelets and other blood elements as well

Anahtar Kelimeler

Child thrombocytophenia peripheral blood smear

Kaynakça

  • Beyan C, nevruz o. Kanama ve tromboz (Çeviri). Harrison İç Hastalıkları Prensipleri (Çeviri). Çeviri Editörü: Yahya Sağlıker. Cilt 1, 15. Edisyon, Nobel Tıp Kitabevleri, 2004: 354-60.
  • McGuinn C, Bussel JB. Disorders of platelets. Lanzkowsky’s manual of pediatric hematology and oncology. Sixth Edition 2016;239-278.
  • https://doi.org/10.1016/B978-0-12-801368-7.00014-4
  • Kılınç Y. Trombositopenilerde tanısal yaklaşım (Algoritma). Türk Pediatrik Hematoloji Derneği, TPHD Eğitim Serisi-IV, Trombosit Hastalıkları. Galenos Yayıncılık, 2017;31-34.
  • Liu Y, Chen S, Sun Y, Lin Q, Liao X, Zhang J, et al. Clinical characteristics of immune thrombocytopenia associated with autoimmune disease: A retrospective study. Medicine (Baltimore) 2016;95:5565.
  • https://doi.org/10.1097/MD.0000000000005565
  • Choi SI, mcClure Pd. Idiopathic thrombocytopenic purpura in childhood. Can Med Assoc J 1967;97:562- 568.
  • Franchini m. The platelet-function analyzer (PFA– 100®) for evaluating primary hemostasis. Hematology 2005;10:177-81.
  • https://doi.org/10.1080/10245330400026097
  • drachman JG. Inherited thrombocytopenia: when a low platelet count does not mean ITP. Blood 2004;103:390-8.
  • https://doi.org/10.1182/blood-2003-05-1742
  • Wilon DB. Acquired platelet disorders. In Nathan and Oski’s Hematology of infancy and childhood. 7th edition. 2009;1553-1590 .
  • Albert mH, noterangelo Ld, occhs Hd. Clinical spectrum, pathophysiology and treatment of theWiskott- Aldrich syndrome. Curr Opin Hematol 2011;18:42-8.
  • https://doi.org/10.1097/MOH.0b013e32834114bc
  • Evans rS, Takahashi K, duane rT. Primary throm- bocytopenic purpura and acquired haemolytic anemia. Arch Int Med 1951;87:48-65.
  • https://doi.org/10.1001/archinte.1951.03810010058005
  • Aul C, Giagounidis A, et al. Evaluating the prognosis of patients with myelodysplastic syndromes. Review article. Ann Hematol 2002;81:485-97.
  • https://doi.org/10.1007/s00277-002-0530-z
  • nakao S, Ishiyama K. Hypomegakaryocytic throm- bocytopenia and increased number of PNH-phenotype cells-an emerging subgroup of myelodysplastic syndro- me showing frequent response to immunosuppression- Response to Refferr to Rafferty&Leach. Correspon- dence. Br J Haematol 2017; 14755.
  • https://doi.org/10.1111/bjh.14755
  • Bussel JB. Alloimmune thrombocytopenia in the fetus and newborn. Semin Thromb Hemos 2001;27:245-52.
  • https://doi.org/10.1055/s-2001-15254
  • roberts I, Stanworth S, murray nA. Thrombocyto- phenia in neonate. Blood Rev 2008;22:173-86.
  • https://doi.org/10.1016/j.blre.2008.03.004
  • WongW, Glader B. Approach to the newborn who has thrombocytophenia. Neo Reviews 2004;5:444-9.
  • https://doi.org/10.1542/neo.5-10-e444
  • murray nA, Howarth LJ, mcCloy mP, Letsky EA, roberts IA. Platelet transfusion in the management of severe thrombocytophenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41.
  • https://doi.org/10.1046/j.1365-3148.2002.00343.x
  • Bussel JB, Zacharoulis S, Kramer K, mcFarland JG, Pauliny J, Kaplan C. Clinical and diagnostic comparison of neonatal alloımmune thrombocytophe- nia to non-immun cases of thromboctrophenia. Pediatr Blood Cancer 2005;45:176-83.
  • https://doi.org/10.1002/pbc.20282
  • George r. Buchanan. Thrombocytopenia during child- hood: What the pediatrician needs to know? Pediatrics in Review 2005;26(11):401-9.
  • Audia S, rossato m, Santegoets K, Spijkers S, Wichers C, Bekker C, et al. Splenic TFH expansion partipipates in B-cell differentiation and antiplatelet antibody production during immune thrombocytophe- nia. Blood 2014;124:2858-86.
  • https://doi.org/10.1182/blood-2014-03-563445
  • Cox K, Price V, Kahr WH. Inherited platelet disor- ders: a clinical approach to diagnosis and management. Expert Rev Hematol 2011;4:455-72.
  • Stasi r. How to approach thrombocytophenia. ASH Education Program Book 2012;191-197.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Makaleleri
Yazarlar

Selime Aydoğdu Bu kişi benim

Serap Karaman Bu kişi benim

Zeynep Karakaş Bu kişi benim

Yayımlanma Tarihi 1 Temmuz 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 16 Sayı: 2

Kaynak Göster

APA Aydoğdu, S., Karaman, S., & Karakaş, Z. (2016). Çocuklarda Trombositopeniye Yaklaşım. Journal of Child, 16(2), 67-73. https://doi.org/10.5222/j.child.2016.067
AMA Aydoğdu S, Karaman S, Karakaş Z. Çocuklarda Trombositopeniye Yaklaşım. Journal of Child. Temmuz 2016;16(2):67-73. doi:10.5222/j.child.2016.067
Chicago Aydoğdu, Selime, Serap Karaman, ve Zeynep Karakaş. “Çocuklarda Trombositopeniye Yaklaşım”. Journal of Child 16, sy. 2 (Temmuz 2016): 67-73. https://doi.org/10.5222/j.child.2016.067.
EndNote Aydoğdu S, Karaman S, Karakaş Z (01 Temmuz 2016) Çocuklarda Trombositopeniye Yaklaşım. Journal of Child 16 2 67–73.
IEEE S. Aydoğdu, S. Karaman, ve Z. Karakaş, “Çocuklarda Trombositopeniye Yaklaşım”, Journal of Child, c. 16, sy. 2, ss. 67–73, 2016, doi: 10.5222/j.child.2016.067.
ISNAD Aydoğdu, Selime vd. “Çocuklarda Trombositopeniye Yaklaşım”. Journal of Child 16/2 (Temmuz 2016), 67-73. https://doi.org/10.5222/j.child.2016.067.
JAMA Aydoğdu S, Karaman S, Karakaş Z. Çocuklarda Trombositopeniye Yaklaşım. Journal of Child. 2016;16:67–73.
MLA Aydoğdu, Selime vd. “Çocuklarda Trombositopeniye Yaklaşım”. Journal of Child, c. 16, sy. 2, 2016, ss. 67-73, doi:10.5222/j.child.2016.067.
Vancouver Aydoğdu S, Karaman S, Karakaş Z. Çocuklarda Trombositopeniye Yaklaşım. Journal of Child. 2016;16(2):67-73.