Klinik ve Histopatolojik Olarak Langerhans Hücreli Histiyositozisi Taklit Eden İnfantile ve Yetişkin Skabiyezi

Öz

Skabiyez, Sarcoptes scabiei'nin epidermiste tüneller açarak ilerlediği bir enfestasyondur. Histopatolojik olarak skabiyez enfestasyonu Langerhans hücre hiperplazisini ortaya çıkarabilir ve bazı durumlarda Langerhans hücreli histiyositoz tanısının yanlış konulmasına neden olabilir. Histopatolojik olarak Langerhans hücreli histiyositoz (LCH) yanlış tanısı alan ve antiskabiyetik tedavilere iyi yanıt veren bir infant ve bir yetişkin skabiyez hastalarını sunduk. Bu nedenle, bu fenomenin farkındalığı, klinisyenlerin bu iki hastalığı farklı prognoz ve tedavilerle ayırt etmelerine yardımcı olabilir.

Anahtar Kelimeler

• Langerhans hücreli histiyositoz
• skabiyez
• infant
• yetişkin

Infantile and Adult Scabies mimicking Langerhans Cell Histiocytosis Clinically and Histopathologically

Öz

Scabies is an infestation caused by the Sarcoptes scabiei burrowing into the epidermis. Histopathologically scabies infestation may reveal Langerhans cell hyperplasia which might cause misdiagnosis of Langerhans cell histiocytosis in some cases. We presented an infant and an adult who had a misdiagnosis of Langerhans cell histiocytosis (LCH) histopathologically and responded well to antiscabietic treatments. Therefore, awareness of this phenomenon might help clinicans to differentiate these two diseases with distinct prognosis and treatments.

Anahtar Kelimeler

• Langerhans Cell Histiocytosis
• Scabies
• Infant
• Adult

Kaynakça

1. Sunderkötter C, Feldmeier H, Fölster-Holst R, et al. S1 guidelines on the diagnosis and treatment of scabies – short version. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 2016;14:1155-67.
2. Sánchez-Borges M, González-Aveledo L, Capriles-Hulett A, et al. Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. Allergol Immunopathol (Madr) 2018;46:276-80.
3. Janik-Moszant A, Tomaszewska R, Szczepański T, et al. Infantile scabies or Langerhans cell histiocytosis? Med Pediatr Oncol 2003;40:111-2.
4. Tidman MJ, Adamson B, Allan S, et al. Childhood scabies mistaken for Langerhans cell histiocytosis. Clin Exp Dermatol 2003;28:111-2.
5. Burch JM, Krol A, Weston WL. Sarcoptes scabiei infestation misdiagnosed and treated as Langerhans cell histiocytosis. Pediatr Dermatol 2004;21:58-62.
6. Bhattacharjee P, Glusac EJ. Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis. J Cutan Pathol 2007;34:716-20.
7. Yang YS, Byun YS, Kim JH, et al. Infantile Scabies Masquerading as Langerhans Cell Histiocytosis. Ann Dermatol 2015;27:349-51.
8. Ruby KN, Loo EY, Mann JA, et al. Post-scabietic nodules: Mimicker of infantile indeterminate cell histiocytosis and potential diagnostic pitfall. J Cutan Pathol 2020;47:52-6.

9. Hashimoto K, Fujiwara K, Punwaney J, et al. Post-scabetic nodules: a lymphohistiocytic reaction rich in indeterminate cells. J Dermatol 2000;27:181-94.
10. Kartono F, Lee EW, Lanum D, et al. Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy. Arch Dermatol 2007;143:626-8.