Comparison of the Effects of Different Molecular Weight Hyaluronic Acid Application in Knee Osteoarthritis

Öz

Objective: The objective of this study was to evaluate the effect of different molecular weight (MW) hyaluronic acid (HA) application on pain and functional parameters in knee osteoarthritis (OA). Methods: This study was designed as retrospectively. Hospital records of the patients who received intraarticular HA injection therapy in our center were screened. The patients were divided into 3 categories according to the MW of the preparates as the follows; Group 1: 0,6-1,2 Milion Da of MW (N=26); Group 2: 1,1- 2,2 Million Da of MW (N=25); and Group 3: 1,7-2,1 Million Da of MW (N=25). All patients were assessed using Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) before the treatment and one month after the injection. Results: A total of 76 patients (61 females, 15 males) with a mean age of 62,1 years (minimum-maximum: 50-70 years) were included. VAS and WOMAC scores did improve significantly in all groups (all for p<0.001). However, no significant difference was observed between the groups in terms of the delta values of the VAS and WOMAC scores between the groups (p: 0,721 and p: 0,595, respectively). Conclusion: In conclusion, significant reductions in VAS and WOMAC scores were observed in all 3 patient groups in our study. Yet, there was no significant difference regarding the MW of HA preparations.

Anahtar Kelimeler

• knee osteoarthritis
• hyaluronic acid
• pain

Diz Osteoartritinde Farklı Molekül Ağırlıklı Hyaluronik Asit Uygulamalarının Etkilerinin Karşılaştırılması

Öz

Amaç: Bu çalışmanın amacı, diz osteoartritinde (OA) farklı moleküler ağırlıklı (MA) hyaluronik asit (HA) uygulamasının ağrı ve fonksiyonel parametreler üzerindeki etkisini değerlendirmektir. Yöntemler: Bu çalışma geriye dönük olarak planlandı. Merkezimizde intraartiküler HA enjeksiyon tedavisi alan hastaların hastane kayıtları tarandı. Preparatların MA'sına göre hastalar aşağıdaki gibi 3 kategoriye ayrıldı; Grup 1: 0,6-1,2 Milyon Da MA (N=26); Grup 2: 1,1- 2,2 Milyon Da MA (N=25); ve Grup 3: 1,7-2,1 Milyon Da MA (N=25). Tüm hastalar, tedaviden önce ve enjeksiyondan bir ay sonra Görsel Analog Skala (VAS) ve Western Ontario ve McMaster Universities Arthritis Index (WOMAC) kullanılarak değerlendirildi. Bulgular: Yaş ortalaması 62,1 yıl (minimum-maksimum: 50-70 yıl) olan toplam 76 hasta (61 kadın, 15 erkek) dahil edildi. VAS ve WOMAC skorları tüm gruplarda anlamlı olarak iyileşti (tümü için p<0,001). Ancak gruplar arasında VAS ve WOMAC puanlarının delta değerleri açısından gruplar arasında anlamlı bir fark gözlenmedi (sırasıyla p: 0,721 ve p: 0,595). Sonuç: Sonuç olarak, çalışmamızda her 3 hasta grubunda da VAS ve WOMAC skorlarında anlamlı düşüşler gözlendi. Ancak, HA preparatlarının MA'sı ile ilgili önemli bir fark yoktu.

Anahtar Kelimeler

• Diz Osteoartriti
• Hyaluronik Asit
• Ağrı

Kaynakça

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