Komplikasyonsuz Kronik Otitis Media’da Thiol/Disülfit Dengesi

Yıl 2019, , 119 - 122, 30.06.2019

Kazım Bozdemir , Bülent Ulusoy , Arife Sezgin Ahmet Akkoz Özcan Erel , Mehmet Hakan Korkmaz

https://doi.org/10.16899/jcm.571633

Öz

Giriş:
Kronik mukozal
inflamatuar bir hastalık olan kronik otitis media patogenezinde oksidatif
stresin rol oynayabileceğini düşündük. Bu amaçla yeni bir oksidatif stres
belirteci ile bu durumu araştırmayı amaçladık.

Gereç
ve yöntemler: Kronik
ototis media tanısı konulan 30 hasta ve sağlıklı gönüllülerden oluşan 30 birey
kontrol grubu olarak çalışmaya dahil edildi. Kan örnekleri hastaneye yatışta
ameliyat öncesinde alındı. Kontrol grubundaki kan örnekleri polikliniğimize
başvuru esnasında alındı. Thiol/disülfit düzeyleri Erel ve Neşelioğlu
tarafından geliştirilen yeni bir yöntemle analiz edildi.

Sonuçlar:
Kronik otitis
media grubuna 30 birey (20 kadın, 10 erkek) dahil edildi. Konrol grubu olarak da
30 birey (8 kadın, 22 erkek) alındı. Gruplar içerindeki cinsiyet dağılımındaki
farklılık istatistiksel olarak anlamlı (p=0.004) iken yaş dağılımı açısından
anlamlı farklılık yoktu(p=0.072). Ölçülen native thiol disülfit ve total thiol
değerleri açısından gruplar arasında anlamlı farlılık yoktu.

Sonuç:Bu çalışma, kronik otitis medialı
hastalarda thiol oksidasyonunun bir sonucu olarak dinamik thiol disülfit
dengesi disülfit formasyonuna doğru kaydığını göstermesine rğmen gruplar
arasında anlamlı bir farklılık bulunmadı.

Anahtar Kelimeler

Oxidative stress, Thiol/disulphide homeostazisi, kronik otitis media

Thiol-disulphide homeostasis in noncomplicated chronic otitis media

Öz

Introduction: We
hypothesized that oxidative stress plays a role in the pathogenesis of chronic
otitis media, chronic mucosal inflammatory disease. We aimed to investigate a
novel oxidative stress marker in this study.

Materıals and methods: Thirty
patient with chronic otitis media as the patient group and 30 healthy volunteer
subjects as the control group were admitted to the study. Blood samples were taken when they admitted to our clinic
before surgical intervention. In healthy volunteers, blood samples were taken
when they were admitted to our policlinic.   
Thiol/disulphide levels were analyzed with a newly developed method by
Erel and Neselioglu.

Results: 30 subjects were included in chronic otitis media
group (20 females, 10 males).  30
subjects were included in the control group (8 females and 22 males). Sex distribution
within the groups was significantly different (p=0.004). There was no
significant difference between groups with respect to the age distribution
(p=0.072). Measured native thiol, disulphide and total thiol values of the
groups were not significantly different from each other.

Conclusion: This study
demonstrated that although dynamic thiol/disulphide homeostasis was shifted
towards disulphide formation as a result of thiol oxidation in patients with
chronic otitis media. But we could not find any significant difference between
groups.

Anahtar Kelimeler

Oxidative stress, Thiol/disulphide homeostasis, chronic otitis media

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