Retrospective evaluation of laboratory, radiological and clinical findings of COVID-19 suspected cases with a public health perspective in Adiyaman Training and Research Hospital

Öz

Aim: The purpose of this study is to evaluate SARS-CoV-2 cases based on clinical evidence from the perspective of public health. Materials and Methods: The data of 354 people were analyzed which were among the patients admitted to the pandemic hospital in Adiyaman in the study. Results: 70.6% of those admitted to the hospital with suspected COVID-19, 60% of those received inpatient treatment and 61.2% of those who were PCR-positive were male. The median age of those admitted to the hospital was 37 years. 90% were in a good general condition. The median length of hospitalization was 7 days. 14.8% PCR-positive patients required mechanical ventilation. Generally, D-dimer, CRP and WBC levels were poor, which were higher in those receiving intensive care (p<0.05). Conclusion: As a result, the disease seems to be more common among men. CT abnormalities are common. D-Dimer, CRP and WBC levels are associated with severe disease.

Anahtar Kelimeler

• Communicable diseases
• COVID-19
• Outbreak

Adıyaman Eğitim Araştırma Hastanesine başvuran COVID-19 şüpheli vakaların laboratuvar, radyolojik ve klinik bulgularının halk sağlığı bakışıyla retrospektif değerlendirilmesi

Öz

Amaç: Bu çalışmanın amacı, SARS-CoV-2 vakalarını halk sağlığı perspektifinden klinik kanıtlara dayalı olarak değerlendirmektir. Gereç ve Yöntem: Araştırmada Adıyaman pandemi hastanesine başvuran hastalardan 354 kişinin verileri incelendi. Bulgular: Hastaneye COVID-19 şüphesi ile başvuranların %70,6'sı, yatarak tedavi görenlerin %60'ı ve PCR pozitif olanların% 61,2'si erkekti. Hastaneye başvuranların ortanca yaşı 37 idi. % 90'ı genel olarak iyi durumdaydı. Ortanca hastanede kalış süresi 7 gündü. PCR pozitif hastaların% 14.8'i mekanik ventilasyona ihtiyaç duydu. Genel olarak D-dimer, CRP ve WBC seviyeleri zayıftı ve yoğun bakım alanlarda daha yüksekti (p<0.05) Sonuç: Sonuç olarak, hastalık erkekler arasında daha yaygın görünmektedir. BT anormallikleri yaygındır. D-Dimer, CRP ve WBC seviyeleri ciddi hastalıkla ilişkilidir.

Anahtar Kelimeler

• Bulaşıcı hastalıklar
• COVİD-19
• Salgın

Kaynakça

1. 1. İtil O, Altınışık Ergur G, Köktürk N, Havlucu Y, Akgün M, Aykaç N, eds. COVID-19 Pandemisi ve Sağlığın Sosyal Bileşenleri, Türk Toraks Derneği COVID-19 E-Kitapları Serisi, Haziran.; 2020
2. 2. Seker M, Özer A, Tosun Z, Korkut C, Doğrul M. Covid-19 Pandemi Değerlendirme Raporu.; 2020. Accessed September 16, 2020.
3. 3. Lauer SA, Grantz KH, Bi Q, et al. The incubation period of coronavirus disease 2019 (CoVID-19) from publicly reported confirmed cases: Estimation and application. Annals of Internal Medicine. 2020;172(9):577-582.
4. 4. Pérez A, Santamaria EK, Operario D, et al. World Health Organization (2020). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Vol 5.; 2017. Accessed October 14, 2020.
5. 5. Karaca B. Clinical Findings of the COVID-19 in the Adult Group. J Biotechnol and Strategic Health Res. 2020;1:85-90.
6. 6. Pan A, Liu L, Wang C, et al. Association of Public Health Interventions with the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020;323(19):1915-1923.
7. 7. Argenzian MG, Bruc SL, Slate CL, et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: Retrospective case series. The BMJ. 2020;369.
8. 8. Mardani R, Ahmadi Vasmehjani A, Zali F, et al. Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. Archives of academic emergency medicine. 2020;8(1):e43.

9. 9. Thai PQ, Toan DTT, Dinh TS, et al. Factors associated with the duration of hospitalization among COVID-19 patients in Vietnam: A survival analysis. Epidemiology and Infection. 2020;148.
10. 10. Hur K, Price CPE, Gray EL, et al. Factors Associated With Intubation and Prolonged Intubation in Hospitalized Patients With COVID-19. Otolaryngology - Head and Neck Surgery (United States). 2020;163(1):170-178. doi:10.1177/0194599820929640
11. 11. Halaçli B, Kaya A, Topeli A. Critically ill COVID-19 patient. Turkish Journal of Medical Sciences. 2020;50(SI-1):585-591.
12. 12. Wu Y, Hou B, Liu J, Chen Y, Zhong P. Risk Factors Associated With Long-Term Hospitalization in Patients With COVID-19: A Single-Centered, Retrospective Study. Frontiers in Medicine. 2020;7:315.
13. 13. Karagiannidis C, Mostert C, Hentschker C, et al. Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. The Lancet Respiratory Medicine. 2020;8(9):853-862.
14. 14. To KKW, Tsang OTY, Leung WS, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. The Lancet Infectious Diseases. 2020;20(5):565-574.
15. 15. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054-1062. 16. Petrilli C, Jones S, Yang J, et al. Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. BMJ. Published online April 11, 2020:2020.04.08.20057794.
16. 17. Wang L. C-reactive protein levels in the early stage of COVID-19. Medecine et Maladies Infectieuses. 2020;50(4):332-334.
17. 18. Zhang L, Yan X, Fan Q, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. Journal of Thrombosis and Haemostasis. 2020;18(6):1324-1329.
18. 19. Mooiweer E, Luijk B, Bonten MJM, Ekkelenkamp MB. C-Reactive protein levels but not CRP dynamics predict mortality in patients with pneumococcal pneumonia. Journal of Infection. 2011;62(4):314-316.
19. 20. Satici C, Demirkol MA, Sargin Altunok E, et al. Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19. International Journal of Infectious Diseases. 2020;98:84-89.