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The Changes In The AntiHBs Values Following COVID-19 Pneumonia

Yıl 2022, Cilt 12, Sayı 4, 537 - 542, 31.07.2022
https://doi.org/10.16899/jcm.1062780

Öz

Background/aim: We aimed to determine if there is a decrease in antiHBS titer below the protective value during Coronavirus-19 disease (COVID-19). Materials and methods: A prospective study was made of 67 patients who had positive antiHbs values checked in the last 1 year. Demographic data and the previous antiHBs values were collected from the patient files and the laboratory findings of new antiHBs titers checked after one months later following COVID-19 infection were compared with the previous ones. Results: In the postcovid evaluation, a statistically significant decrease in the antiHBs levels of COVID-19 patients was determined with respect to previous values before COVID-19 infection (p<0,001). Conclusion: In our study, we found that there was a statistically significant decrease in AntiHBs levels after COVID-19 infection, but none of them were below protective antiHBs levels. As a result, we can say a booster vaccination against hepatitis B is not needed during or after COVID-19 infection, but it would be appropriate to support it with studies with a higher number of patients.

Kaynakça

  • 1. Horby P, Lim WS, Emberson JR, et al. Dexamethazone in Hospitalized patients with COVID-19-preliminary report. The new England Journal of Medicine. 2021 Feb25; 384(8):693704. PMID: 32678530 doi:10.1056/NEJMoa2021436.
  • 2. Koffas A, Dolman GE, Kennedy PTF. Hepatitis B virus reactivationin patients treated with immunesuppressive drugs: a practical guide for clinicians. Clin Med(Lond). 2018 Jun; 18(3):212-218. PMID: 29858430 doi: 10.7861/clinmedicine.18-3-212
  • 3. Lubel JS, Testro AG, Angus PW. Hepatitis B Virus reactivation following immunesuppressive therapy: guidelines for prevention and management. Intern Med J. 2007 Oct;37(10):705-12. PMID: 17894766 doi: 10.1111/j.1445-5994.2007.01479.x.
  • 4. Colson P, Borentain P, Coso D, et al. Hepatitis B virus reactivation inHbsAg negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase. Virology, 2015oct, 484:354-363. PMID: 26186574 doi: 10.1016/j.virol.2015.06.017.
  • 5. Rodriguez-Tajes S, Miralpeix A, Costa J, et al. Low risk of hepatitis B reactivation in patients with severe COVID-19 who receive immunosuppressive therapy. J Viral Hepat. 2021 Jan 28(1):89-94. PMID: 32969557 doi:10.1111/jvh.13410.Epub 2020 dct 12.
  • 6. Perillo RP, Gish R, Falek-Ytter YT. American Gastroenterological Association Institute technical review on prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy. Gastroenterology.2015;148:221-44. PMID: 25447852 doi: 10.1053/j.gastro.2014.10-038
  • 7. Yalcin Kehribar D, Okuyucu M, Ozgen M, Ketenci YB, Ayyıldız T, Yıldırım B. Impact of tumor necrosis factor alpha antagonist treatment on antibody titer of hepatitis B surface antigen. J Surg Med. 2020; 4(8):678-681 doi:10.28982/josam.777871
  • 8. Cho Y, Yu SJ, Cho EJ, et al. High titers of anti-HBs prevent rituximab related viral reactivation in resolved hepatitis B patients with non-Hodgkin’s lymphoma. J Med Virol.2016 Jun;88(6):1010-7. PMID: 26531242 doi:10.1002/jmv.24423
  • 9. Tamori A, Koike T, Goto H, et al. Prospective study of reactivation of hepatitis B virus in patients with rheumatoid artrhritis who received immunosuppressive therapy, evaluation of both HBsAg positive and HBsAg negative cohorts. J Gastroenterol.2011;46:556-64. PMID: 21246383 doi: 10.1007/s00535-010-0367-5
  • 10. Vassilopoulos D, Apostokopoulou A, Hadziyannis E, et al. Long term safety of anti-TNF treatment in patients with rheumatic diseases and chronic or resolved hepatitis B virus infection. Ann Rheum Dis.2010;69:1352-5. PMID: 20472596 doi: 10.1136/ard.2009.127233
  • 11. Guglielmo D, Alessandra Toletone A, Barberis I, et al. Persistance of protective anti-HBs antibody levels and amnestic response to HBV booster. Vaccination: A cross-sectional study among healthcare students 20 years following in Italy. Hum vaccine Immunother.2017 Feb;13(2):440-444. PMID: 27925503 doi:10.1080/21645515.2017.1264788.

COVID-19 Pnömonisi Sonrası AntiHBs Değerlerindeki Değişiklikler

Yıl 2022, Cilt 12, Sayı 4, 537 - 542, 31.07.2022
https://doi.org/10.16899/jcm.1062780

Öz

Amaç: Coronavirus-19 hastalığı (COVID-19) sırasında antiHBS titresinin koruyucu değerin altına düşüp düşmediğini belirlemeyi amaçladık. Gereç ve Yöntem: Son 1 yıl içinde pozitif antiHbs değerleri kontrol edilen 67 hasta ile prospektif bir çalışma yapıldı. Demografik veriler ve önceki antiHBs değerleri hasta dosyalarından toplandı ve COVID-19 enfeksiyonundan bir ay sonra kontrol edilen yeni antiHBs titrelerinin laboratuvar bulguları öncekilerle karşılaştırıldı. Bulgular: COVID-19 sonrası yapılan değerlendirmede COVID-19 hastalarının antiHBs düzeylerinde COVID-19 enfeksiyonu öncesi önceki değerlere göre istatistiksel olarak anlamlı düşüş saptandı(p<0,001). Sonuç: Çalışmamızda COVID-19 enfeksiyonu sonrası AntiHBs düzeylerinde istatistiksel olarak anlamlı bir düşüş olduğunu ancak bunun koruyucu antiHBs düzeyinin altında olmadığını gördük. Sonuç olarak COVID-19 enfeksiyonu sırasında veya sonrasında hepatit B'ye karşı güçlendirici aşıya gerek olmadığını söyleyebiliriz ancak hasta sayısı daha yüksek olan çalışmalarla desteklenmesi uygun olur.

Kaynakça

  • 1. Horby P, Lim WS, Emberson JR, et al. Dexamethazone in Hospitalized patients with COVID-19-preliminary report. The new England Journal of Medicine. 2021 Feb25; 384(8):693704. PMID: 32678530 doi:10.1056/NEJMoa2021436.
  • 2. Koffas A, Dolman GE, Kennedy PTF. Hepatitis B virus reactivationin patients treated with immunesuppressive drugs: a practical guide for clinicians. Clin Med(Lond). 2018 Jun; 18(3):212-218. PMID: 29858430 doi: 10.7861/clinmedicine.18-3-212
  • 3. Lubel JS, Testro AG, Angus PW. Hepatitis B Virus reactivation following immunesuppressive therapy: guidelines for prevention and management. Intern Med J. 2007 Oct;37(10):705-12. PMID: 17894766 doi: 10.1111/j.1445-5994.2007.01479.x.
  • 4. Colson P, Borentain P, Coso D, et al. Hepatitis B virus reactivation inHbsAg negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase. Virology, 2015oct, 484:354-363. PMID: 26186574 doi: 10.1016/j.virol.2015.06.017.
  • 5. Rodriguez-Tajes S, Miralpeix A, Costa J, et al. Low risk of hepatitis B reactivation in patients with severe COVID-19 who receive immunosuppressive therapy. J Viral Hepat. 2021 Jan 28(1):89-94. PMID: 32969557 doi:10.1111/jvh.13410.Epub 2020 dct 12.
  • 6. Perillo RP, Gish R, Falek-Ytter YT. American Gastroenterological Association Institute technical review on prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy. Gastroenterology.2015;148:221-44. PMID: 25447852 doi: 10.1053/j.gastro.2014.10-038
  • 7. Yalcin Kehribar D, Okuyucu M, Ozgen M, Ketenci YB, Ayyıldız T, Yıldırım B. Impact of tumor necrosis factor alpha antagonist treatment on antibody titer of hepatitis B surface antigen. J Surg Med. 2020; 4(8):678-681 doi:10.28982/josam.777871
  • 8. Cho Y, Yu SJ, Cho EJ, et al. High titers of anti-HBs prevent rituximab related viral reactivation in resolved hepatitis B patients with non-Hodgkin’s lymphoma. J Med Virol.2016 Jun;88(6):1010-7. PMID: 26531242 doi:10.1002/jmv.24423
  • 9. Tamori A, Koike T, Goto H, et al. Prospective study of reactivation of hepatitis B virus in patients with rheumatoid artrhritis who received immunosuppressive therapy, evaluation of both HBsAg positive and HBsAg negative cohorts. J Gastroenterol.2011;46:556-64. PMID: 21246383 doi: 10.1007/s00535-010-0367-5
  • 10. Vassilopoulos D, Apostokopoulou A, Hadziyannis E, et al. Long term safety of anti-TNF treatment in patients with rheumatic diseases and chronic or resolved hepatitis B virus infection. Ann Rheum Dis.2010;69:1352-5. PMID: 20472596 doi: 10.1136/ard.2009.127233
  • 11. Guglielmo D, Alessandra Toletone A, Barberis I, et al. Persistance of protective anti-HBs antibody levels and amnestic response to HBV booster. Vaccination: A cross-sectional study among healthcare students 20 years following in Italy. Hum vaccine Immunother.2017 Feb;13(2):440-444. PMID: 27925503 doi:10.1080/21645515.2017.1264788.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Perihan ÖZKAN GÜMÜŞKAYA> (Sorumlu Yazar)
Prof. Dr. Cemil Taşcıoğlu City Hospital
0000-0002-0838-9220
Türkiye


Özgür ALTUN>
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL OKMEYDANI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0003-1810-7490
Türkiye


Nur KARAKÜTÜK YÜZTAŞ>
UNIVERSITY OF HEALTH SCIENCES, İSTANBUL OKMEYDANI HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE
0000-0002-8274-7014
Türkiye


Neslihan ÖZSOY>
UNIVERSITY OF HEALTH SCIENCES, İSTANBUL OKMEYDANI HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE
0000-0001-8660-1648
Türkiye


Gülten AYDIN TUTAK>
UNIVERSITY OF HEALTH SCIENCES, İSTANBUL OKMEYDANI HEALTH RESEARCH CENTER
0000-0003-4167-0564
Türkiye


Emine YILDIRIM>
UNIVERSITY OF HEALTH SCIENCES, İSTANBUL GAZİOSMANPAŞA TAKSİM HEALTH RESEARCH CENTER
0000-0003-2733-402X
Türkiye


Mine ADAŞ>
UNIVERSITY OF HEALTH SCIENCES, İSTANBUL OKMEYDANI HEALTH RESEARCH CENTER
0000-0003-3008-6581
Türkiye


Mehmet KÜÇÜK>
UNIVERSITY OF HEALTH SCIENCES, İSTANBUL OKMEYDANI HEALTH RESEARCH CENTER
0000-0003-1720-3819
Türkiye

Destekleyen Kurum yok
Proje Numarası reg: E- 48670771- 514.10
Erken Görünüm Tarihi 1 Haziran 2022
Yayımlanma Tarihi 31 Temmuz 2022
Kabul Tarihi 29 Mayıs 2022
Yayınlandığı Sayı Yıl 2022, Cilt 12, Sayı 4

Kaynak Göster

AMA Özkan Gümüşkaya P. , Altun Ö. , Karakütük Yüztaş N. , Özsoy N. , Aydın Tutak G. , Yıldırım E. , Adaş M. , Küçük M. The Changes In The AntiHBs Values Following COVID-19 Pneumonia. J Contemp Med. 2022; 12(4): 537-542.