Öz
Melatonin (N-acetyl-5-methoxytryptamine) pineal bezden salgılanan ve triptofandan üretilen bir nörohümoral hormondur.
Eksojen formulasyonu uyku bozukluklarında ve Jet lag (insanda
24 saatlik biyolojik etkinlik çevriminin ani değişmeler nedeniyle
uğradığı geçici değişiklik ve düzensizlik) tedavisinde kullanılır.
Melatonin dünyada ve ülkemizde uyku ilacı olarak eczanelerde
reçetesiz satılmaktadır. Bu makalede intihar amacıyla melatonin
içen bir vaka sunduk
Anahtar Kelimeler
Kaynakça
- Balantine J, Hagman J. More on melatonin. Jam Acad Child Adolesc Psychiatry 1997; 36: 1013. [CrossRef]
- Zhadanova IV, Wurtman RJ, Lynch HJ, et al. Sleep inducing efects of low doses of melatonin ingested in the evening. Clin Parmacol Ther 1995; 57: 552-8. [CrossRef]
- Holliman BJ, Chyka PA. Problems in assessment of acute mealtonin overdose. South Med J 1997; 90: 451-3. [CrossRef]
- Chung CH. An upsurge in melatonin overdose: Case report. Hong Kong Emer Med J 2001; 8: 150-2.
- Arent J. Safety of Melatonin in long term use. J Biol Rhythms 1997; 12: 673-81. [CrossRef]
- Nordlung JJ, Lerner AB. The effect of oral melatonin on skin color and on the release of pituitary hormones. J Clin Endocrinol Metab 1977; 45: 768-74. [CrossRef]
- Jarvis D. Melatonin is available over the counter. BMJ 1996; 313: 629. [CrossRef]
- Waldhauser F, Lynch HJ, Wurtman RJ. Melatonin in human body fluids: clinical significance. The pineal gland. Reiter RJ (ed) New York Raven Pres, 1984: 345-70.
- de Haan M, Macnab J, Kent DA, Kennedy J. Melatonin overdose resul- ting in respiratory depression and coma responsive to naloxone. Clin Toxicol 2005; 43: 759-60.
- Dremza IK, Cheshchevik VT, Zabrodskaia SV, Maksimchik IuZ, Sudnikovich EIu, Lapshina EA, et al. Hepatotoxic efects of acetaminophen. Protective pro- perties of tryptophan-derivatives. Biomed Khim 2010; 56: 710-8.
- Kurus M, Esrefoglu M, Sogutlu G, Atasever A. Melatonin prevents cyclosporine- induced hepatotoxicity in rats. Med Princ Pract 2009; 18: 407-10. [CrossRef] 133
Öz
Melatonin, also known chemically as N-acetyl-5-methoxytryptamine, is produced in the pineal gland from the precursor tryptophan and secreted into the blood. Its exogenous forms are used for the treatment of sleep disorders and jet lag. Melatonin is sold as a sleep drug at pharmacies in Turkey and throughout the world. In this study, we present a case of attempted suicide by the ingestion of melatonin
Kaynakça
- Balantine J, Hagman J. More on melatonin. Jam Acad Child Adolesc Psychiatry 1997; 36: 1013. [CrossRef]
- Zhadanova IV, Wurtman RJ, Lynch HJ, et al. Sleep inducing efects of low doses of melatonin ingested in the evening. Clin Parmacol Ther 1995; 57: 552-8. [CrossRef]
- Holliman BJ, Chyka PA. Problems in assessment of acute mealtonin overdose. South Med J 1997; 90: 451-3. [CrossRef]
- Chung CH. An upsurge in melatonin overdose: Case report. Hong Kong Emer Med J 2001; 8: 150-2.
- Arent J. Safety of Melatonin in long term use. J Biol Rhythms 1997; 12: 673-81. [CrossRef]
- Nordlung JJ, Lerner AB. The effect of oral melatonin on skin color and on the release of pituitary hormones. J Clin Endocrinol Metab 1977; 45: 768-74. [CrossRef]
- Jarvis D. Melatonin is available over the counter. BMJ 1996; 313: 629. [CrossRef]
- Waldhauser F, Lynch HJ, Wurtman RJ. Melatonin in human body fluids: clinical significance. The pineal gland. Reiter RJ (ed) New York Raven Pres, 1984: 345-70.
- de Haan M, Macnab J, Kent DA, Kennedy J. Melatonin overdose resul- ting in respiratory depression and coma responsive to naloxone. Clin Toxicol 2005; 43: 759-60.
- Dremza IK, Cheshchevik VT, Zabrodskaia SV, Maksimchik IuZ, Sudnikovich EIu, Lapshina EA, et al. Hepatotoxic efects of acetaminophen. Protective pro- perties of tryptophan-derivatives. Biomed Khim 2010; 56: 710-8.
- Kurus M, Esrefoglu M, Sogutlu G, Atasever A. Melatonin prevents cyclosporine- induced hepatotoxicity in rats. Med Princ Pract 2009; 18: 407-10. [CrossRef] 133
Ayrıntılar
| Diğer ID | JA24MV76ED |
|---|---|
| Bölüm | Case Report |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Ekim 2012 |
| Gönderilme Tarihi | 1 Ekim 2012 |
| Yayımlandığı Sayı | Yıl 2012 Cilt: 3 Sayı: 4 |