EXAMINATION OF SOME POTENTIAL MEDICINAL PLANT SPECIES IN THE TREATMENT OF ALOPECIA AREATA

Öz

Objective: Alopecia areata (AA) is an autoimmune disease that causes hair loss due to the body’s immune system attacking hair follicles. Although various treatments are currently used for Alopecia areata, herbal remedies have gained prominence due to the increasing interest of patients in natural products. This study aims to examine the efficacy and applicability of plants with therapeutic potential in the treatment of Alopecia areata. Result and Discussion: In recent years, the use of natural plant extracts in the treatment of Alopecia Areata has gained to significant attention. Many of the plants discussed in this study have anti-inflammatory and immunomodulatory properties, making them potentially beneficial in the treatment of Alopecia areata. Additionally, herbal products promote hair growth through mechanisms, such as stimulating cell proliferation in hair follicles, improving blood circulation in the scalp, inhibiting the 5α-reductase enzyme, inducing the release of growth factors, and reducing the levels of inflammatory cytokines. However, further research is required to elucidate the mechanisms of action of some of these plants.

Anahtar Kelimeler

• Alopecia areata
• herbal extract
• hair growth

ALOPESİ AREATA TEDAVİSİNDE POTANSİYEL BAZI TIBBİ BİTKİ TÜRLERİNİN İNCELENMESİ

Öz

Amaç: Alopesi areata (AA), vücut bağışıklık sisteminin saç foliküllerine saldırması sonucu saç kaybına neden olan otoimmün bir hastalıktır. Günümüzde Alopesi areatanın tedavisinde çeşitli yöntemler kullanılmakta, ancak hastaların doğal ürünlere olan ilgisinin artması nedeniyle bitkisel tedavi yöntemleri ön plana çıkmaktadır. Bu çalışmada, Alopesi areata tedavisinde terapötik potansiyele sahip bitki türlerinin etkinliğinin ve uygulanabilirliğinin incelenmesi amaçlanmıştır. Sonuç ve Tartışma: Alopesi areata tedavisinde doğal bitki ekstrelerinin kullanımı, son yıllarda önemli bir ilgi odağı haline gelmiştir. Çalışmada ele alınan bitkilerin birçoğu, anti-enflamatuvar ve immünomodülatör özellikleri ile alopesi areata tedavisinde potansiyel faydalar sağlayabilecek niteliktedir. Ayrıca, bitkisel ürünler, saç foliküllerindeki hücrelerin çoğalmasını teşvik etmek, saç derisindeki kan dolaşımını artırmak, 5α-redüktaz enzimini inhibe etmek, büyüme faktörlerinin salınımını tetiklemek veya enflamatuvar sitokinlerin seviyesini düşürmek gibi çeşitli mekanizmalarla saç büyümesinin teşvik edilmesine katkıda bulunmaktadır. Bunun yanında, bazı bitkilerin etki mekanizmasının aydınlatılması için daha fazla çalışma gereklidir.

Anahtar Kelimeler

• Alopesi areata
• bitki ekstresi
• saç uzaması

Kaynakça

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