SILVER NANOCOMPOSITES: A GLIMPSE INTO THEIR GAME-CHANGING ROLES IN ANTIBACTERIAL THERAPY

Öz

Objective: The application of nanocomposites in biomedicine is a promising approach that scientists have discovered to eradicate infection-causing microorganisms properly and safely. Silver nanocomposites (AgNCs) can be recognized as hopeful antibacterial prospects that can fight both in vivo and in vitro infection-causing bacteria. The purpose of this review is to identify the variables that influence the antibacterial effect of AgNCs, given the pressing need for new, effective antibacterial agents. Result and Discussion: In the literature, many reports indicate the capacity of AgNCs to combat both gram-positive and gram-negative bacteriomers, including those that are resistant to multiple drugs. This capacity is due to the multiple simultaneous modes of AgNCs action. This capacity also results in a synergistic impact on bacteria when mutually applied with natural or synthetic antibacterial medications. Because of their unique properties, AgNCs can be effectively used to manage or prevent infections in a variety of medical and healthcare products. The study focuses on the synthetic methodologies and antibacterial mechanisms of AgNCs. Furthermore, factors influencing the action of AgNCs against bacteriomers as well as the advantages of combining AgNCs with antibiotics to create novel antibacterial combinations were covered. The authors wanted to make it possible to reduce the dose required and prevent unfavorable off-target effects associated with both by providing access to the reviewed data.

Anahtar Kelimeler

• Antibacterial activity
• antibiotic
• silver nanocomposites
• synergistic effect

GÜMÜŞ NANOKOMPOZİTLER: ANTİBAKTERİYEL TERAPİDEKİ OYUN DEĞİŞTİRİCİ ROLLERİNE BİR BAKIŞ

Öz

Amaç: Nanokompozitlerin biyomedikal alanda uygulanması, bilim insanlarının enfeksiyona neden olan mikroorganizmaları uygun ve güvenli bir şekilde ortadan kaldırmak için keşfettiği umut verici bir yaklaşımdır. Gümüş nanokompozitler (AgNC'ler), hem in vivo hem de in vitro enfeksiyona neden olan bakterilerle savaşabilen umut verici antibakteriyel olasılıklar olarak kabul edilebilir. Bu incelemenin amacı, yeni ve etkili antibakteriyel ajanlara olan acil ihtiyaç göz önüne alındığında, AgNC'lerin antibakteriyel etkisini etkileyen değişkenleri belirlemektir. Sonuç ve Tartışma: Literatürde, birçok rapor, AgNC'lerin çoklu ilaçlara dirençli olanlar da dahil olmak üzere hem gram pozitif hem de gram negatif bakteriyomerlerle savaşma kapasitesini göstermektedir. Bu kapasite, AgNC'lerin birden fazla eşzamanlı etki modundan kaynaklanmaktadır. Bu kapasite, doğal veya sentetik antibakteriyel ilaçlarla birlikte uygulandığında bakteriler üzerinde sinerjik bir etkiyle de sonuçlanmaktadır. Benzersiz özellikleri nedeniyle, AgNC'ler çeşitli tıbbi ve sağlık ürünlerindeki enfeksiyonları yönetmek veya önlemek için etkili bir şekilde kullanılabilir. Çalışma, AgNC'lerin sentetik metodolojilerine ve antibakteriyel mekanizmalarına odaklanmaktadır. Ayrıca, AgNC'lerin bakteriyomerlere karşı etkisini etkileyen faktörler ve AgNC'leri antibiyotiklerle birleştirerek yeni antibakteriyel kombinasyonlar oluşturmanın avantajları ele alınmıştır. Yazarlar, incelenen verilere erişim sağlayarak gereken dozu azaltmayı ve her ikisiyle ilişkili olumsuz hedef dışı etkileri önlemeyi mümkün kılmak istemişlerdir.

Anahtar Kelimeler

• Antibakteriyel aktivite
• antibiyotik
• gümüş nanokompozitler
• sinerjik etki

Kaynakça

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