RUMEX CRISPUS L.: AN OVERVIEW

Öz

Objective: Plants have been utilized for various purposes for centuries. Many plants have been used not only for nutrition but also in the treatment of diseases. Today, plants play a significant role in the food and pharmaceutical industries. In this study, the species Rumex crispus L., belonging to the Polygonaceae family, has been evaluated in terms of its traditional uses, phytochemical content, and medicinal effects. Literature search was conducted using Google Scholar, Web of Science and Scopus databases.

Result and Discussion: The leaves and branches of R. crispus are used as food in various regions. Its parts, such as leaves, roots, seeds, and fruits, have been recorded as being used in the treatment of various diseases in traditional medicine. It has been observed that the plant contains compounds such as anthraquinones, naphthalene, flavonoids, and various volatile oil components. R. crispus has been reported to possess several effects, including antimicrobial, antioxidant, anti-inflammatory, and hepatoprotective properties. It is believed that further studies on this species could be beneficial in the future.

Anahtar Kelimeler

• Biological activities
• phytochemical contents
• Polygonaceae
• Rumex crispus
• traditional use

RUMEX CRISPUS L.: GENEL BAKIŞ

Öz

Amaç: Bitkilerden yüzyıllardır çeşitli amaçlarla faydalanılmıştır. Birçok bitki beslenme amaçlı kullanıldığı gibi hastalıkların tedavisinde de kullanılmıştır. Günümüzde gıda ve ilaç endüstrisinde bitkiler önem taşımaktadır. Bu araştırmada Polygonaceae familyasına ait Rumex crispus L. türü halk arasındaki kullanımı, fitokimyasal içeriği ve tıbbi etkileri bakımından değerlendirilmiştir. Google Akademik, Web of Science ve Scopus veritabanları kullanılarak literatür taraması yapılmıştır.

Sonuç ve Tartışma: R. crispus türünün yaprak ve dalları çeşitli yörelerde gıda olarak kullanılmaktadır. Yaprak, kök, tohum, meyve gibi kısımlarının birçok hastalığın tedavisinde halk arasında değerlendirildiği kayıtlıdır. Bitkinin antrakinon, naftalen ve flavanoit yapısında bileşikler ve çeşitli uçucu yağ bileşenleri içerdiği gözlenmiştir. R. crispus'un antimikrobiyal, antioksidan, antienflamatuar, hepatoprotektif gibi çeşitli etkilere sahip olduğu belirtilmiştir. Bu tür üzerinde ileride daha farklı çalışmalarının yapılmasının faydalı olabileceği düşünülmektedir.

Anahtar Kelimeler

• Biyolojik aktiviteler
• fitokimyasal içerikler
• geleneksel kullanım
• Polygonaceae
• Rumex crispus

Kaynakça

1. 1. Petrovska, B. (2012). Historical review of medicinal plants′ usage. Pharmacognosy Reviews, 6(11), 1-5. [CrossRef]
2. 2. Prasathkumar, M., Anisha S., Dhrisya, C., et al. (2021). Therapeutic and pharmacological efficacy of selective Indian medicinal plants-A review. Phytomedicine Plus, 1(2), 100029. [CrossRef]
3. 3. Chaachouay, N., Zidane, L. (2024). Plant-derived natural products: A source for drug discovery and development. Drugs Drug Candidates, 3(1), 184-207. [CrossRef]
4. 4. Li, J.J., Li, Y.X., Li, N., et al. (2022). The genus Rumex (Polygonaceae): An ethnobotanical, phytochemical and pharmacological review. Natural Products and Bioprospecting, 12(21), 1-29. [CrossRef]
5. 5. Dastan, T., Sarac, H. (2018). Determination of the nutritional element concentrations of Evelik plant (Rumex crispus L.). Cumhuriyet Science Journal, 39(4), 1020-1024.
6. 6. Sefalı, A. (2023). Wild herbaceous plants sold in Bayburt public market. V. Baskent International Conference on Multidisciplinary Studies, Ankara, Türkiye, 21-22.
7. 7. Mishra, A.P., Sharifi-Rad, M., Shariati, M.A., et al. (2018). Bioactive compounds and health benefits of edible Rumex species-a review. Cellular and Molecular Biology, 64(8) 27-34.
8. 8. Çakır, E.A. (2017). Traditional knowledge of wild edible plantsof Iğdır Province (East Anatolia, Turkey). Acta Societatis Botanicorum Poloniae, 86(4), 3568. [CrossRef]

9. 9. Mahklouf, M.H. (2019). Ethnobotanical study of edible wild plants in Libya. European Journal of Ecology, 5(2), 30-40.
10. 10. Miskoska Milevska, E., Stamatoska, A., Jordanovska, S. (2020). Traditional uses of wild edible plants in the Republic of North Macedonia. Phytologia Balcanica, 26(1), 155-162.
11. 11. Kazancı, C., Oruç, S., Mosulishvili, M., et al. (2021). Wild plants used as vegetables by transhumant people around the Georgia-Turkey Border in the Western Lesser Caucasus. Acta Societatis Botanicorum Poloniae, 90(906). [CrossRef]
12. 12. Tuttu, G., Abay, G., Yildirimli, S. (2019). Some wild edible plants of Tosya District (Kastamonu, Turkey). International Journal of Scientific & Technology Research, 5(3), 129-135. [CrossRef]
13. 13. Bozkurt, A.E. (2024). Therapeutic uses of the medicinal plants growing in the villages of Yakutiye district, Erzurum, Türkiye. Journal of Herbal Medicine, 44, 100853. [CrossRef]
14. 14. Kadıoğlu, S., Kadıoğlu, B., Karagöz Sezer, K. (2021). Ethnobotanical properties of natural plants in Kop Mountain Pass (Bayburt /Turkey). Biological Diversity and Conservation, 14(2), 264-276. [CrossRef]
15. 15. Gürbüz, İ., Özatkan, G., Akaydın, G., et al. (2021). Ethnopharmacobotanical findings of medicinal plants in the Kızılcahamam District of Ankara, Turkey. Turkish Journal of Pharmaceutical Sciences, 18(6), 667-682. [CrossRef]
16. 16. Bulut, G., Haznedaroğlu, M.Z., Doğan, A., et al. (2017). An ethnobotanical study of medicinal plants in Acıpayam (Denizli-Turkey). Journal of Herbal Medicine, 10, 64-81. [CrossRef]
17. 17. Kupeli, E., Orhan, I., Yesilada, E. (2007). Evaluation of some plants used in Turkish folk medicine for their anti-inflammatory and antinociceptive activities. Pharmaceutical Biology, 45(7), 547-555. [CrossRef]
18. 18. Polat, R. (2019). Ethnobotanical study on medicinal plants in Bingöl (City center) (Turkey). Journal of Herbal Medicine, 16, 100211. [CrossRef]
19. 19. Ugulu, I., Baslar, S., Yorek, N., et al. (2009). The investigation and quantitative ethnobotanical evaluation of medicinal plants used around Izmir province, Turkey. Journal of Medicinal Plants Research, 3(5), 345-367.
20. 20. Altundag, E., Ozturk, M. (2011). Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia Social and Behavioral Sciences, 19, 756-777. [CrossRef]
21. 21. Özgen, U., Kaya, Y., Houghton, P. (2012). Folk medicines in the villages of Ilıca District (Erzurum, Turkey). Turkish Journal of Biology, 36, 93-106. [CrossRef]
22. 22. Pieroni, A., Cattero, V. (2019). Wild vegetables do not lie: Comparative gastronomic ethnobotany and ethnolinguistics on the Greek traces of the mediterranean diet of Southeastern Italy. Acta Botanica Brasilica, 33(2), 198-211. [CrossRef]
23. 23. Ozdemir Nath, E., Kultur, S. (2022). An ethnobotanical study of medicinal plants in Savaştepe (Balıkesir-Turkey). Clinical and Experimental Health Sciences, 12, 954-980. [CrossRef]
24. 24. Bulut, G., Tuzlacı, E. (2015). An ethnobotanical study of medicinal plants in Bayramiç (Çanakkale-Turkey). Marmara Pharmaceutical Journal, 19, 268-282.
25. 25. Baharvand Ahmadi, B., Bahmani, M., Eftekhari, Z., et al. (2016). Overview of medicinal plants used for cardiovascular system disorders and diseases in ethnobotany of different areas in Iran. Journal of Herbmed Pharmacology, 5(1), 39-44.
26. 26. Sarper, F., Akaydın, G., Şimşek, I., et al. (2009). An ethnobotanical field survey in the Haymana district of Ankara Province in Turkey. Turkish Journal of Biology, 33, 79-88. [CrossRef]
27. 27. Korkmaz, M., Karakuş, S. (2015). Traditional uses of medicinal plants of Üzümlü District, Erzincan, Turkey. Pakistan Journal of Botany, 47(1), 125-134.
28. 28. Guarrera, P.M., Forti, G., Marignoli, S. (2005). Ethnobotanical and ethnomedicinal uses of plants in the district of Acquapendente (Latium, Central Italy). Journal of Ethnopharmacology, 96, 429-444. [CrossRef]
29. 29. Ibadullayeva, S.C., Shiraliyeva, G.S., Gurbanova, L.Z., et al. (2021). Ethnopharmacological use of wild vegetable plants belonging to the Polygonaceae Juss. family spread in the Azerbaijan flora. Biodiversity Journal, 12(3), 733-740. [CrossRef]
30. 30. Rajaei, P., Mohamadi, N. (2012). Ethnobotanical study of medicinal plants of Hezar Mountain allocated in south east of Iran. Iranian Journal of Pharmaceutical Research, 11(4), 1153-1167.
31. 31. Baskan, S., Daut-Ozdemir, A., Gunaydın, K., et al. (2007). Analysis of anthraquinones in Rumex crispus by micellar electrokinetic chromatography. Talanta, 71, 747-750. [CrossRef]
32. 32. Günaydın, K., Topçu, G., Ion, R.M. (2010). 1,5-Dihydroxyanthraquinones and an anthrone from roots of Rumex crispus. Natural Product Letters, 16(1), 65-70.
33. 33. Li, Y.X., Li, N., Li, J.J., et al. (2022). New seco-anthraquinone glucoside from the roots of Rumex crispus. Natural Products and Bioprospecting, 12, 29. [CrossRef]
34. 34. Uzun, M., Guvenalp, Z., Kazaz, C., et al. (2020). Matrix metalloproteinase inhibitor and sunscreen effective compounds from Rumex crispus L.: Isolation, identification, bioactivity, and molecular docking study. Phytochemical Analysis, 31, 818-834. [CrossRef]
35. 35. Saoudi, M.M., Bouajila, J., Rahmani, R., et al. (2021). Phytochemical composition, antioxidant, antiacetylcholinesterase, and cytotoxic activities of Rumex crispus L. International Journal of Analytical Chemistry, 6675436, 1-16. [CrossRef]
36. 36. Idris, O.A., Wintola, O.A., Afolayan, A.J. (2019). Comparison of the proximate composition, vitamins (ascorbic acid, α-tocopherol, and retinol), anti-nutrients (phytate and oxalate), and the GC-MS analysis of the essential oil of the root and leaf of Rumex crispus L. Plants, 8, 51. [CrossRef]
37. 37. Çoruh, I., Gormez, A.A., Ercisli, S., et al. (2008). Total phenolic content, antioxidant, and antibacterial activity of Rumex crispus grown wild in Turkey. Pharmaceutical Biology, 46(9), 634-638. [CrossRef]
38. 38. Mandefro, S.B., Jabasingh, A.S., Tefera, Z.T., et al. (2024). Rumex crispus L: Profiling and evaluation of the phytochemical properties, antioxidant potential, and antimicrobial activities of the root extracts. Biomass Conversion and Biorefinery, 15, 7005-7020. [CrossRef]
39. 39. Lee, K.H., Rhee, K.H. (2013). Antimalarial activity of nepodin isolated from Rumex crispus. Archives of Pharmacal Research, 36, 430-435. [CrossRef]
40. 40. Daştan, S.D., Durukan, H., Demirbaş, A., et al. (2019). Bioactivity and therapeutic properties of Evelik (Rumex crispus), a naturally growing and edible plant in Sivas Province. Turkish Journal of Agriculture-Food Science and Technology, 7(sp2), 67-71. [CrossRef]
41. 41. Demir, S., Bozkurt, B., Önür, M.A., et al. (2017). Determination of antioxidant properties of Rumex crispus and Scrophularia canina subsp. bicolor. International Journal of Secondary Metabolite, 4(3), 55-57. [CrossRef]
42. 42. Feduraev, P., Chupakhina, G., Maslennikov, P., et al. (2019). Variation in phenolic compounds content and antioxidant activity of different plant organs from Rumex crispus L. and Rumex obtusifolius L. at different growth stages. Antioxidants, 8, 237. [CrossRef]
43. 43. Feduraev, P., Skrypnik, L., Nebreeva, S., et al. (2022). Variability of phenolic compound accumulation and antioxidant activity in wild plants of some Rumex species (Polygonaceae). Antioxidants, 11, 311. [CrossRef]
44. 44. Minh, T.N., Van, T.M., Andriana, Y., et al. (2019). Antioxidant, xanthine oxidase, α-amylase, and α-glucosidase inhibitory activities of bioactive compounds from Rumex crispus L. root. Molecules, 24, 3899. [CrossRef]
45. 45. Maksimović, Z., Kovacević, N., Lakušić, B., et al. (2011). Antioxidant activity of yellow dock (Rumex crispus L., Polygonaceae) fruit extract. Phytotherapy Research, 25, 101-105. [CrossRef]
46. 46. Shiwani, S., Singh, N.K., Wang, M.H. (2012). Carbohydrase inhibition and anti-cancerous and free radical scavenging properties along with DNA and protein protection ability of methanolic root extracts of Rumex crispus. Nutrition Research and Practice, 6(5), 389-395. [CrossRef]
47. 47. Yıldırım, A., Mavi, A., Kara, A.A. (2001). Determination of antioxidant and antimicrobial activities of Rumex crispus L. extracts. Journal of Agricultural and Food Chemistry, 49, 4083-4089. [CrossRef]
48. 48. Eom, T., Kim, E., Kim, J.S. (2020). In vitro antioxidant, antiinflammation, and anticancer activities and anthraquinone content from Rumex crispus root extract and fractions. Antioxidants, 9, 726. [CrossRef]
49. 49. Anwar, A., Nazer, S., Andleeb, S., et al. (2024). Evaluation of hepatoprotective effect of Rumex crispus on CCl₄-induced damage in mice. Journal of Wildlife and Ecology, 8(1), 36-42.
50. 50. Aguila Muñoz, D.G., Jiménez Montejo, F.E., López López, V.E., et al. (2023). Evaluation of α-glucosidase inhibition and antihyperglycemic activity of extracts obtained from leaves and flowers of Rumex crispus L. Molecules, 28, 5760. [CrossRef]
51. 51. Çelik, Ö., Koç, E. (2019). Rumex crispus extract exerts anti-diabetic properties in streptozotocin-induced diabetes in rats. Journal of the Institute of Science and Technology, 9(4), 1937-1943. [CrossRef]
52. 52. Süntar, İ., Demirel, M.A., Ceribasi, A.O., et al. (2021). Preventive effect of Rumex crispus L. on surgically induced intra-abdominal adhesion model in rats. DARU Journal of Pharmaceutical Sciences, 29, 101-115. [CrossRef]
53. 53. Shim, K.S., Lee, B., Ma, J.Y. (2017). Water extract of Rumex crispus prevents bone loss by inhibiting osteoclastogenesis and inducing osteoblast mineralization. BMC Complementary and Alternative Medicine, 17, 483. [CrossRef]
54. 54. Uzun, M., Demirezer, L.O. (2019). Anti-aging power of Rumex crispus L.: Matrix metalloproteinases inhibitor, sun protective, and antioxidant. South African Journal of Botany, 124, 364-371. [CrossRef]