EN
TR
EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS
Öz
We examined the tissue thiobarbituric acid reactive substances (TBARS), non-protein thiol (NP-SH) and total thiol (T-SH) group levels in order to deduce the role of cyclooxygenase-2 (COX-2) pathway on nicotine-induced oxidative tissue damage. Wistar Albino male rats were divided into three groups: Group I; 0.9% saline (ip), Group II; nicotine ditartarate (1.5 mg/kg, ip), Grup III; celecoxib (15 mg/kg, ip)+nicotine ditartarate (1.5 mg/kg ip). At the end of the 7th day, liver, lung, kidney, heart and brain tissues were removed. Nicotine treatment significantly increased TBARS, NP-SH and T-SH levels in all tissues. However, celecoxib treatment prior the nicotine injection, significantly decreased the TBARS levels and T-SH contents in all tissues in addition to NP-SH content in kidney, liver, lung and brain compared to nicotine group. Nicotine treatment caused excessive production of free radicals and evoked the antioxidant molecules. However, inhibition of cyclooxygenase-2 selectively prevented the nicotine-induced oxidative tissue damage dramatically. We concluded that, cyclooxygenase-2 pathway may be a notable mechanism of the nicotine toxicity
Anahtar Kelimeler
Ayrıntılar
Birincil Dil
İngilizce
Konular
-
Bölüm
-
Yayımlanma Tarihi
1 Mart 2010
Gönderilme Tarihi
1 Mart 2010
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2010 Cilt: 39 Sayı: 1
APA
Ünüvar, S., & Aktay, G. (2010). EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS. Journal of Faculty of Pharmacy of Ankara University, 39(1), 35-42. https://doi.org/10.1501/Eczfak_0000000552
AMA
1.Ünüvar S, Aktay G. EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS. Ankara Ecz. Fak. Derg. 2010;39(1):35-42. doi:10.1501/Eczfak_0000000552
Chicago
Ünüvar, Songül, ve Göknur Aktay. 2010. “EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS”. Journal of Faculty of Pharmacy of Ankara University 39 (1): 35-42. https://doi.org/10.1501/Eczfak_0000000552.
EndNote
Ünüvar S, Aktay G (01 Mart 2010) EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS. Journal of Faculty of Pharmacy of Ankara University 39 1 35–42.
IEEE
[1]S. Ünüvar ve G. Aktay, “EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS”, Ankara Ecz. Fak. Derg., c. 39, sy 1, ss. 35–42, Mar. 2010, doi: 10.1501/Eczfak_0000000552.
ISNAD
Ünüvar, Songül - Aktay, Göknur. “EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS”. Journal of Faculty of Pharmacy of Ankara University 39/1 (01 Mart 2010): 35-42. https://doi.org/10.1501/Eczfak_0000000552.
JAMA
1.Ünüvar S, Aktay G. EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS. Ankara Ecz. Fak. Derg. 2010;39:35–42.
MLA
Ünüvar, Songül, ve Göknur Aktay. “EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS”. Journal of Faculty of Pharmacy of Ankara University, c. 39, sy 1, Mart 2010, ss. 35-42, doi:10.1501/Eczfak_0000000552.
Vancouver
1.Songül Ünüvar, Göknur Aktay. EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON NICOTINE- INDUCED OXIDATIVE STRESS. Ankara Ecz. Fak. Derg. 01 Mart 2010;39(1):35-42. doi:10.1501/Eczfak_0000000552