THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS

Öz

Objectives: The purpose of this work is to study the hepatoprotective properties of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and infectious hepatitis models in chickens.

Materials and Methods: Biochemical examination of blood and liver serum was carried out on intact broiler chickens Cobb 500 cross. All groups of chickens were kept separate in different cells in the same room for the same microclimate parameters in accordance with the established requirements.

Result and Discussion: As a result of research on the model of hepatitis in chickens caused by tetracycline, established hepatoprotective effect of potassium compound 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate,  which is not inferior to the referent drug - Thiotriazolin^®. Based on the results of the biochemical study, hepatoprotective properties of the combination of the above compound with the antibiotic Saroflox^®, combination of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with  classical antibiotic Enrofloxacin^® on the model of infectious hepatitis.

Anahtar Kelimeler

• 1.2.4-triazole
• hepatoprotective activity
• biochemical indicators

TETRASİKLİN VE İNFEKSİYÖZ HEPATİT ŞARTLARI ALTINDA 1,2,4-TRİAZOL TÜREVLERİNİN KARACİĞER KORUYUCU AKTİVİTELERİNİN ARAŞTIRILMASI

Öz

Amaç: Bu çalışmanın amacı tavuklarda oluşturulan tetrasiklin ve infeksiyöz hepatit modellerinde potasyum 2-((4-amino-5-(morfolinometil)-4H-1,2,4-triazol-3-il)tiyo)asetatın karaciğer koruyucu özelliklerini çalışmaktır.

        Gereç ve Yöntem: Kan ve karaciğer serumunun biyokimyasal analizi Cobb 500 cinsi sağlıklı etçi civcivlerde yapılmıştır. Belirlenen koşullara uygun olarak aynı mikroklima parametreleri için tüm civciv grupları aynı oda içinde farklı kafeslerde ayrı olarak tutulmuştur.

       Sonuç ve Tartışma: Civcivlerde tetrasiklin ile oluşturulan hepatit modelindeki çalışmanın sonucu olarak potasyum 2-((4-amino-5- (morfolinometil)-4H-1,2,4-triazol-3-il)tio)asetat’ın belirlenen karaciğer koruyucu etkileri referans ilaç olan Thiotriazolin’den daha aşağıda bulunmamıştır. Biyokimyasal çalışmanın sonuçları, yukarıda belirtilen bileşiğin Saroflox antibiyotik ile kombinasyonunun, klasik antibiyotik Enrofloxacin ile potasyum 2-((4-amino-5- (morfolinometil)-4H-1,2,4-triazol-3-il)tio)asetat’ın kombinasyonunun karaciğer koruyucu özelliklerini göstermektedir.

Anahtar Kelimeler

• biyokimyasal belirteçler
• karaciğer koruyucu aktivite
• 1.2.3-triazol

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