THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS

Yıl 2019, , 135 - 146, 01.06.2019

Roman Shcherbyna , Yevgenia Vashchyk

https://doi.org/10.33483/jfpau.487173

Cited By: 6

Öz

Objectives:
The purpose of this work is to study
the hepatoprotective properties of potassium 2-((4-amino-5-
(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and
infectious hepatitis models in chickens.

Materials
and Methods: Biochemical examination of blood and
liver serum was carried out on intact broiler chickens Cobb 500 cross. All
groups of chickens were kept separate in different cells in the same room for the
same microclimate parameters in accordance with the established requirements.

Result and Discussion: As a result of research on the model
of hepatitis in chickens caused by tetracycline, established hepatoprotective
effect of potassium compound
2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate,  which is not inferior to the referent drug - Thiotriazolin^®. Based on the
results of the biochemical study, hepatoprotective properties of the
combination of the above compound with the antibiotic Saroflox^®, combination of potassium 2-((4-amino-5-
(morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with  classical antibiotic Enrofloxacin^® on the model of infectious hepatitis.

Anahtar Kelimeler

1.2.4-triazole, hepatoprotective activity, biochemical indicators

TETRASİKLİN VE İNFEKSİYÖZ HEPATİT ŞARTLARI ALTINDA 1,2,4-TRİAZOL TÜREVLERİNİN KARACİĞER KORUYUCU AKTİVİTELERİNİN ARAŞTIRILMASI

Öz

Amaç: Bu
çalışmanın amacı tavuklarda oluşturulan tetrasiklin ve infeksiyöz hepatit modellerinde
potasyum 2-((4-amino-5-(morfolinometil)-4H-1,2,4-triazol-3-il)tiyo)asetatın
karaciğer koruyucu özelliklerini çalışmaktır.

        Gereç ve Yöntem: Kan ve
karaciğer serumunun biyokimyasal analizi Cobb 500 cinsi sağlıklı etçi
civcivlerde yapılmıştır. Belirlenen koşullara uygun olarak aynı mikroklima
parametreleri için tüm civciv grupları aynı oda içinde farklı kafeslerde ayrı
olarak tutulmuştur.

       Sonuç ve Tartışma:
Civcivlerde tetrasiklin ile oluşturulan
hepatit modelindeki çalışmanın sonucu olarak potasyum 2-((4-amino-5-
(morfolinometil)-4H-1,2,4-triazol-3-il)tio)asetat’ın belirlenen karaciğer
koruyucu etkileri referans ilaç olan Thiotriazolin’den daha aşağıda
bulunmamıştır. Biyokimyasal çalışmanın sonuçları, yukarıda belirtilen bileşiğin
Saroflox antibiyotik ile kombinasyonunun, klasik antibiyotik Enrofloxacin ile
potasyum 2-((4-amino-5-
(morfolinometil)-4H-1,2,4-triazol-3-il)tio)asetat’ın kombinasyonunun karaciğer
koruyucu özelliklerini göstermektedir.

Anahtar Kelimeler

biyokimyasal belirteçler, karaciğer koruyucu aktivite, 1.2.3-triazol

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