ARONIA SP. MEYVELERİNİN KİMYASAL BİLEŞİMİ VE BİYOLOJİK AKTİVİTELERİ

Öz

Amaç: Aronia türleri bakka tipi (berry) meyvelere sahip olup, yapılarında antosiyaninler başta olmak üzere yüksek miktarda fenolik bileşikler taşır. Zengin kimyasal içeriğinden ve güçlü antioksidan aktivitesinden dolayı fonksiyonel gıda olarak adlandırılmakta, dünya üzerinde kullanımı ve kültürü yaygınlaşmaktadır. Bu derleme ile Aronia meyvelerinin kimyasal bileşimi, biyolojik aktiviteleri ve konuyla ilgili güncel araştırmalar sunulmuştur.

Sonuç ve Tartışma: Aronia meyvelerinin geleneksel kullanımı yanında, kimyasal bileşimi, hastalıklardan korunma ve hastalıkların tedavisindeki rolü incelenmiştir. Biyoaktiviteden sorumlu başlıca moleküller (siyanidin türevi glikozitler, flavonoidler, prosiyanidinler ve fenolik asitler gibi fenolik yapıda bileşikler) ve oranları ile ilgili bilgiler verilmiştir. Güçlü antioksidan aktivitesi nedeniyle birçok kronik ve dejeneratif hastalık üzerinde tedavi edici etkisi olduğuna, ayrıca antiinflamatuvar, antidiyabetik, antimutajenik ve kardiyoprotektif aktivite gösterdiğine ilişkin detaylı veriler bulunmaktadır.

Anahtar Kelimeler

• Antioksidan
• antosiyanin
• Aronia melanocarpa
• biyolojik aktivite
• fenolik bileşikler

CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF ARONIA SP. BERRIES

Öz

Objective: Aronia species have bacca (berry) type fruits and contain high amount of phenolics especially anthocyanins. Due to their rich chemical content and strong antioxidant activity, they are called functional food, their uses and cultivation is becoming widespread in the world. In this review, the data on the chemical composition, biological activity of Aronia fruits, and current researches on the fruits are presented.

Result and Discussion: Besides the traditional use of Aronia fruits, their chemical composition and their role in the treatment and protection of diseases have been presented. Information about percentages and structures of main compounds (phenolic compounds such as cyanidin glycosides, flavonoids, procyanidins, and phenolic acids) which are responsible for bioactivity of berries are mentioned. Detailed data are available on the therapeutic effects of fruits on many chronic and degenerative diseases thanks to the their strong antioxidant activity, Also there are substantial studies regarding anti-inflammatory, antidiabetic, antimutagenic, and cardioprotective activities of Aronia fruits.

Anahtar Kelimeler

• Aronia melanocarpa
• Anthocyanin
• antioxidant
• biological activity
• phenolic compounds

Kaynakça

1. 1. Beattie, J., Crozier, A., Duthie, G. (2005). Potential health benefi ts of berries. Current Nutrition & Food Science 1: 71-86
2. 2. Kulling, S.E., and Rawel, H.M. (2008). Chokeberry (Aronia melanocarpa) - A review on the characteristic components and potential health effects. Planta Medica, 74(13), 1625–1634. https://doi.org/10.1055/s-0028-1088306
3. 3. Chrubasik, C., Li, G., & Chrubasik, S. (2010). The clinical effectiveness of chokeberry: A systematic review. Phytotherapy Research, 24(8), 1107–1114. https://doi.org/10.1002/ptr.3226
4. 4. Oszmiański, J., & Lachowicz, S. (2016). Effect of the production of dried fruits and juicefrom chokeberry (Aronia melanocarpa L.) on the content and antioxidative activity of bioactive compounds. Molecules, 21, 1098.
5. 5. Tolić, M. T., Krbavčić, I. P., Vujević, P., Milinović, B., Jurčević, I. L., & Vahčić, N. (2017). Effects of weather conditions on phenolic content and antioxidant capacity in juice of chokeberries (Aronia melanocarpa L.). Polish Journal of Food and Nutrition Sciences, 67,67–74.
6. 6. Sidor, A., Drożdżyńska, A., & Gramza-Michałowska, A. (2019). Black chokeberry (Aronia melanocarpa)and its products as potential health-promoting factors - An overview. Trends in Food Science and Technology, 89(March 2018), 45–60. https://doi.org/10.1016/j.tifs.2019.05.006
7. 7. Tanaka T., & Tanaka A. (2001) Chemical components and characteristics of black chokeberry. J Jpn Soc Food Sci Technol; 48: 606–610
8. 8. Chrubasik, C., Li, G., & Chrubasik, S. (2010). The clinical effectiveness of chokeberry: A systematic review. Phytotherapy Research, 24(8), 1107–1114. https://doi.org/10.1002/ptr.3226

9. 9. Konić-Ristić, A., Šavikin, K., Zdunić, G., Janković, T., Juranic, Z., Menković, N., & Stanković, I. (2011). Biological activity and chemical composition of different berry juices. Food Chemistry, 125(4), 1412–1417. https://doi.org/10.1016/j.foodchem.2010.10.018
10. 10. Bajec, M. R., & Pickering, G. J. (2008). Astringency: Mechanisms and Perception. Critical Reviews in Food Science and Nutrition, 48(9), 858–875. https://doi.org/10.1080/10408390701724223
11. 11. Kokotkiewicz, A., Jaremicz, Z., & Luczkiewicz, M. (2010). Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. Journal of Medicinal Food, 13(2), 255–269. https://doi.org/10.1089/jmf.2009.0062
12. 12. Jurikova, T., Mlcek, J., Skrovankova, S., Sumczynski, D., Sochor, J., Hlavacova, I., Snopek, l., Orsavova, J. (2017). Fruits of black chokeberry aronia melanocarpa in the prevention of chronic diseases. Molecules, 22(6), 1–23. https://doi.org/10.3390/molecules22060944
13. 13. Jakobek, L., Šeruga, M., Medvidović-Kosanović, M., Novak, I., & Strossmayer, J. J. (2007). Antioxidant Activity and Polyphenols of Aronia in Comparison to other Berry Species. Agriculturae Conspectus Scientifi Cus, 72(4), 301–306. Retrieved from https://pdfs.semanticscholar.org/b5a2/cd69aca19e5f3efae06f5b10497b8585a47e.pdf
14. 14. Krenn, L., Steitz, M., Schlicht, C., Kurth, H., & Gaedcke, F. (2007). Anthocyanin- and proanthocyanidin-rich extracts of berries in food supplements--analysis with problems. Die Pharmazie, 62(11), 803–812.
15. 15. Jeppsson, N., & Johansson, R. (2000). Changes in fruit quality in black chokeberry (Aronia melanocarpa) during maturation. Journal of Horticultural Science and Biotechnology, 75(3), 340–345. https://doi.org/10.1080/14620316.2000.11511247
16. 16. Skupień, K., & Oszmiański, J. (2007). The effect of mineral fertilization on nutritive value and biological activity of chokeberry fruit. Agricultural and Food Science, 16(1), 46–55. https://doi.org/10.2137/145960607781635822
17. 17. Wawer, I., Wolniak, M., & Paradowska, K. (2006). Solid state NMR study of dietary fiber powders from aronia, bilberry, black currant and apple. Solid State Nuclear Magnetic Resonance, 30(2), 106–113. https://doi.org/https://doi.org/10.1016/j.ssnmr.2006.05.001
18. 18. Brand, M. H., Connolly, B. A., Levine, L. H., Richards, J. T., Shine, S. M., & Spencer, L. E. (2017). Anthocyanins, total phenolics, ORAC and moisture content of wild and cultivated dark-fruited Aronia species. Scientia Horticulturae, 224(November), 332–342. https://doi.org/10.1016/j.scienta.2017.06.021
19. 19. Oszmiański, J., & Wojdylo, A. (2005). Aronia melanocarpa phenolics and their antioxidant activity. European Food Research and Technology, 221(6), 809–813. https://doi.org/10.1007/s00217-005-0002-5
20. 20. Benvenuti, S., Pellati, F., Melegari, M., & Bertelli, D. (2006). Polyphenols, Anthocyanins, Ascorbic Acid, and Radical Scavenging Activity of Rubus, Ribes, and Aronia. Journal of Food Science, 69(3), FCT164–FCT169. https://doi.org/10.1111/j.1365-2621.2004.tb13352.x
21. 21. Zheng, W., & Wang, S. Y. (2003). Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. Journal of Agricultural and Food Chemistry, 51(2), 502–509. https://doi.org/10.1021/jf020728u
22. 22. Wu, X., Gu, L., Prior, R. L., & McKay, S. (2004). Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. Journal of Agricultural and Food Chemistry, 52(26), 7846–7856. https://doi.org/10.1021/jf0486850
23. 23. Kapci, B., Neradová, E., Čížková, H., Voldřich, M., Rajchl, A., & Capanoglu, E. (2013). Investigating the antioxidant potential of chokeberry (Aronia melanocarpa) products. Journal of Food and Nutrition Research, 52(4), 219–229.
24. 24. Teleszko, M., & Wojdyło, A. (2015). Comparison of phenolic compounds and antioxidant potential between selected edible fruits and their leaves. Journal of Functional Foods, 14, 736–746. https://doi.org/10.1016/j.jff.2015.02.041
25. 25. Xie, L., Lee, S. G., Vance, T. M., Wang, Y., Kim, B., Lee, J.-Y., Chun, O.K., & Bolling, B. W. (2016). Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract. Food Chemistry, 211, 860–868. https://doi.org/10.1016/J.FOODCHEM.2016.05.122
26. 26. Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International Journal of Biomedical Science, 4(2), 89–96.
27. 27. Ambriz-Pérez, D. L., Leyva-López, N., Gutierrez-Grijalva, E. P., & Heredia, J. B. (2016). Phenolic compounds: Natural alternative in inflammation treatment. A Review. Cogent Food & Agriculture, 2(1). https://doi.org/10.1080/23311932.2015.1131412
28. 28. Martin, D. A., Taheri, R., Brand, M. H., Draghi, A., Sylvester, F. A., & Bolling, B. W. (2014). Anti-inflammatory activity of aronia berry extracts in murine splenocytes. Journal of Functional Foods, 8, 68–75. https://doi.org/10.1016/J.JFF.2014.03.004
29. 29. Xu, J., & Mojsoska, B. (2013). The immunomodulation effect of aronia extract lacks association with its antioxidant anthocyanins. Journal of Medicinal Food, 16(4), 334–342. https://doi.org/10.1089/jmf.2012.0151
30. 30. Appel, K., Meiser, P., Millán, E., Collado, J. A., Rose, T., Gras, C. C., … Muñoz, E. (2015). Chokeberry (Aronia melanocarpa (Michx.) Elliot) concentrate inhibits NF-κB and synergizes with selenium to inhibit the release of pro-inflammatory mediators in macrophages. Fitoterapia, 105, 73–82. https://doi.org/10.1016/J.FITOTE.2015.06.009
31. 31. Ho, G. T. T., Bräunlich, M., Austarheim, I., Wangensteen, H., Malterud, K. E., Slimestad, R., & Barsett, H. (2014). Immunomodulating activity of Aronia melanocarpa polyphenols. International Journal of Molecular Sciences, 15(7), 11626–11636. https://doi.org/10.3390/ijms150711626
32. 32. Banjari, I., Misir, A., Šavikin, K., Jokić, S., Molnar, M., De Zoysa, H. K. S., & Waisundara, V. Y. (2017). Antidiabetic Effects of Aronia melanocarpa and Its Other Therapeutic Properties. Frontiers in Nutrition, 4(November), 1–6. https://doi.org/10.3389/fnut.2017.00053
33. 33. Qin, B., & Anderson, R. A. (2012). An extract of chokeberry attenuates weight gain and modulates insulin, adipogenic and inflammatory signalling pathways in epididymal adipose tissue of rats fed a fructose-rich diet. British Journal of Nutrition, 108(4), 581–587. https://doi.org/10.1017/S000711451100599X
34. 34. Worsztynowicz, P., Napierała, M., Białas, W., Grajek, W., & Olkowicz, M. (2014). Pancreatic α-amylase and lipase inhibitory activity of polyphenolic compounds present in the extract of black chokeberry (Aronia melanocarpa L.). Process Biochemistry, 49(9), 1457–1463. https://doi.org/10.1016/j.procbio.2014.06.002
35. 35. Bräunlich, M., Slimestad, R., Wangensteen, H., Brede, C., Malterud, K. E., & Barsett, H. (2013). Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors. Nutrients, 5(3), 663–678. https://doi.org/10.3390/nu5030663
36. 36. Banjari, I., Misir, A., Šavikin, K., Jokić, S., Molnar, M., De Zoysa, H. K. S., & Waisundara, V. Y. (2017). Antidiabetic Effects of Aronia melanocarpa and Its Other Therapeutic Properties. Frontiers in Nutrition, 4(November), 1–6. https://doi.org/10.3389/fnut.2017.00053
37. 37. Valcheva-Kuzmanova, S., Kuzmanov, K., Tancheva, S., & Belcheva, A. (2007). Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic rats. Methods and findings in experimental and clinical pharmacology, 29(2), 101–105. https://doi.org/10.1358/mf.2007.29.2.1075349
38. 38. Yamane, T., Kozuka, M., Konda, D., Nakano, Y., Nakagaki, T., Ohkubo, I., & Ariga, H. (2016). Improvement of blood glucose levels and obesity in mice given aronia juice by inhibition of dipeptidyl peptidase IV and α-glucosidase. The Journal of Nutritional Biochemistry, 31, 106–112. https://doi.org/10.1016/J.JNUTBIO.2016.02.004
39. 39. Jurikova, T., Mlcek, J., Skrovankova, S., Sumczynski, D., Sochor, J., Hlavacova, I., Snopek, L., & Orsavova, J. (2017). Fruits of black chokeberry aronia melanocarpa in the prevention of chronic diseases. Molecules, 22(6), 1–23. https://doi.org/10.3390/molecules22060944
40. 40. Sikora, J., Broncel, M., Markowicz, M., Chałubiński, M., Wojdan, K., & Mikiciuk-Olasik, E. (2012). Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. European Journal of Nutrition, 51(5), 549–556. https://doi.org/10.1007/s00394-011-0238-8
41. 41. Skoczyñska, A., Jêdrychowska, I., Porêba, R., Affelska-, A., Turczyn, B., Wojakowska, A., & Andrzejak, R. (2007). Influence of chokeberry juice on arterial blood pressure and lipid parameters in men with mild hypercholesterolemia. 177–182.
42. 42. Kim, B., Park, Y., Wegner, C. J., Bolling, B. W., & Lee, J. (2013). Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells. Journal of Nutritional Biochemistry, 24(9), 1564–1570. https://doi.org/10.1016/j.jnutbio.2013.01.005
43. 43. Naruszewicz, M., Laniewska, I., Millo, B., & Dłuzniewski, M. (2007). Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis, 194(2), e179–e184. https://doi.org/10.1016/j.atherosclerosis.2006.12.032
44. 44. Ryszawa, N., Kawczyńska-Drózdz, A., Pryjma, J., Czesnikiewicz-Guzik, M., Adamek-Guzik, T., Naruszewicz, M., Korbut, R., & Guzik, T. J. (2006). Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 57(4), 611–626.
45. 45. Bell, D. R., & Gochenaur, K. (2006). Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. Journal of applied physiology (Bethesda, Md. : 1985), 100(4), 1164–1170. https://doi.org/10.1152/japplphysiol.00626.2005
46. 46. Malik, M., Zhao, C., Schoene, N., Guisti, M. M., Moyer, M. P., & Magnuson, B. A. (2003). Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. Nutrition and cancer, 46(2), 186–196. https://doi.org/10.1207/S15327914NC4602_12
47. 47. Lala, G., Malik, M., Zhao, C., He, J., Kwon, Y., Giusti, M. M., & Magnuson, B. A. (2006). Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutrition and cancer, 54(1), 84–93. https://doi.org/10.1207/s15327914nc5401_10
48. 48. Zhao, C., Giusti, M. M., Malik, M., Moyer, M. P., & Magnuson, B. A. (2004). Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. Journal of agricultural and food chemistry, 52(20), 6122–6128. https://doi.org/10.1021/jf049517a
49. 49. Gasiorowski, K., Szyba, K., Brokos, B., Kołaczyńska, B., Jankowiak-Włodarczyk, M., & Oszmiański, J. (1997). Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits. Cancer letters, 119(1), 37–46. https://doi.org/10.1016/s0304-3835(97)00248-6