ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ

Yıl 2020, Cilt: 44 Sayı: 1, 167 - 187, 31.01.2020

Ayça Adalı Anıl Yirün , Belma Koçer-gümüşel Pınar Erkekoğlu

https://doi.org/10.33483/jfpau.523804

Cited By: 3

Öz

Amaç: Bu derleme kapsamında, Alzheimer hastalığının genel özelliklerinden bahsedilecek; bu hastalığın patofizyolojisinde rol oynayabileceği bildirilen biyolojik ajanlardan ve bu konuda yapılmış çalışmalardan söz edilecektir.

Sonuç ve Tartışma: Dünya çapında artan
nüfusa bağlı olarak yaşlı nüfusun artması Alzheimer hastalığının görülme
sıklığının artmasına yol açmıştır. Son yıllarda, farklı demans türleri ve
özellikle de Alzheimer hastalığı konusundaki bilimsel araştırmalar
hızlanmıştır. Hastalığın multi-genetik nedenlerle ortaya çıkabileceği
bilinmektedir. Ancak, birçok biyolojik ajana maruziyetin de Alzheimer
hastalığının patofizyolojisinde rol oynayabileceği belirtilmektedir.
Literatürde Herpes simplex virüs tip-1 (HSV-1), insan immünoyetmezlik virüsü 1
(HIV-1) ve Helicobacter pylori gibi enfeksiyon etkenlerinin ve vücutta endojen
olarak bulunan prion proteinlerinin bu hastalığının gelişimine yol açabileceği
belirtilmektedir. Diğer taraftan, diyabet gibi hastalıkların da Alzheimer
hastalığının gelişimini hızlandırabileceğine dair araştırmalar bulunmaktadır. 

Anahtar Kelimeler

Alzheimer hastalığı, Helicobacter pylori, Herpes simplex virüs tip-1 (HSV-1), İnsan immünoyetmezlik virüsü 1 (HIV-1)

THE POSSIBLE EFFECTS OF BIOLOGICAL AGENTS ON THE DEVELOPMENT OF ALZHEIMER’S DISEASE

Öz

Objective:
In this review, we
will mainly focus on the the general properties of Alzheimer’s disease and will
also mention the biological agents that are suggested to play roles in the
pathophysiology of Alzeheimer’s disease and the studies performed on these
agents.

Result
and Discussion: The
increase in elderly population due to the increasing population worldwide has
led to an increase in the prevalance of Alzheimer’s disease. In the last years,
scientific studies on different types of dementia and particularly on
Alzheimer’s disease have accelerated. It is known that this disease has
multi-genetic grounds. However, exposure to several biological agents are also
suggested to play roles in the pathophysiology of Alzheimer’s disease. There
are studies in literature suggesting that infections like Herpes simplex virus
tip-1 (HSV-1), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori
and endogenous prion poteins can contribute to the development of this disease.
On the other hand, there are studies suggesting that diseases like diabetes can
expedite the development of Alzheimer’ss disease. 

Anahtar Kelimeler

Alzheimer's disease, Helicobacter pylori, Herpes simplex virus type 1, human immunodeficiency virus type 1 (HIV-1)

Kaynakça

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