Yıl 2020, Cilt 44 , Sayı 1, Sayfalar 167 - 187 2020-01-31

THE POSSIBLE EFFECTS OF BIOLOGICAL AGENTS ON THE DEVELOPMENT OF ALZHEIMER’S DISEASE
ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ

Ayça ADALI [1] , Anıl YİRÜN [2] , Belma KOÇER-GÜMÜŞEL [3] , Pınar ERKEKOĞLU [4]


Objective: In this review, we will mainly focus on the the general properties of Alzheimer’s disease and will also mention the biological agents that are suggested to play roles in the pathophysiology of Alzeheimer’s disease and the studies performed on these agents.

Result and Discussion: The increase in elderly population due to the increasing population worldwide has led to an increase in the prevalance of Alzheimer’s disease. In the last years, scientific studies on different types of dementia and particularly on Alzheimer’s disease have accelerated. It is known that this disease has multi-genetic grounds. However, exposure to several biological agents are also suggested to play roles in the pathophysiology of Alzheimer’s disease. There are studies in literature suggesting that infections like Herpes simplex virus tip-1 (HSV-1), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori and endogenous prion poteins can contribute to the development of this disease. On the other hand, there are studies suggesting that diseases like diabetes can expedite the development of Alzheimer’ss disease. 

Amaç: Bu derleme kapsamında, Alzheimer hastalığının genel özelliklerinden bahsedilecek; bu hastalığın patofizyolojisinde rol oynayabileceği bildirilen biyolojik ajanlardan ve bu konuda yapılmış çalışmalardan söz edilecektir.

Sonuç ve Tartışma: Dünya çapında artan nüfusa bağlı olarak yaşlı nüfusun artması Alzheimer hastalığının görülme sıklığının artmasına yol açmıştır. Son yıllarda, farklı demans türleri ve özellikle de Alzheimer hastalığı konusundaki bilimsel araştırmalar hızlanmıştır. Hastalığın multi-genetik nedenlerle ortaya çıkabileceği bilinmektedir. Ancak, birçok biyolojik ajana maruziyetin de Alzheimer hastalığının patofizyolojisinde rol oynayabileceği belirtilmektedir. Literatürde Herpes simplex virüs tip-1 (HSV-1), insan immünoyetmezlik virüsü 1 (HIV-1) ve Helicobacter pylori gibi enfeksiyon etkenlerinin ve vücutta endojen olarak bulunan prion proteinlerinin bu hastalığının gelişimine yol açabileceği belirtilmektedir. Diğer taraftan, diyabet gibi hastalıkların da Alzheimer hastalığının gelişimini hızlandırabileceğine dair araştırmalar bulunmaktadır. 

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Birincil Dil tr
Konular Farmakoloji ve Eczacılık
Bölüm Derleme
Yazarlar

Orcid: 0000-0002-8811-6002
Yazar: Ayça ADALI
Kurum: HACETTEPE ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK TOKSİKOLOJİ ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0002-4050-8832
Yazar: Anıl YİRÜN
Kurum: HACETTEPE ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK TOKSİKOLOJİ ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0003-4311-2291
Yazar: Belma KOÇER-GÜMÜŞEL
Kurum: LOKMAN HEKİM ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASÖTİK TOKSİKOLOJİ ANABİLİM DALI
Ülke: Turkey


Orcid: 0000-0003-4713-7672
Yazar: Pınar ERKEKOĞLU (Sorumlu Yazar)
Kurum: HACETTEPE ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK TOKSİKOLOJİ ANABİLİM DALI
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Ocak 2020

Bibtex @derleme { jfpanu523804, journal = {Journal of Faculty of Pharmacy of Ankara University}, issn = {1015-3918}, eissn = {2564-6524}, address = {Ankara University Faculty of Pharmacy Degol Str. TR-06100 Tandogan/Ankra/TURKEY}, publisher = {Ankara Üniversitesi}, year = {2020}, volume = {44}, pages = {167 - 187}, doi = {10.33483/jfpau.523804}, title = {ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ}, key = {cite}, author = {ADALI, Ayça and YİRÜN, Anıl and KOÇER-GÜMÜŞEL, Belma and ERKEKOĞLU, Pınar} }
APA ADALI, A , YİRÜN, A , KOÇER-GÜMÜŞEL, B , ERKEKOĞLU, P . (2020). ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ. Journal of Faculty of Pharmacy of Ankara University , 44 (1) , 167-187 . DOI: 10.33483/jfpau.523804
MLA ADALI, A , YİRÜN, A , KOÇER-GÜMÜŞEL, B , ERKEKOĞLU, P . "ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ". Journal of Faculty of Pharmacy of Ankara University 44 (2020 ): 167-187 <https://dergipark.org.tr/tr/pub/jfpanu/issue/52196/523804>
Chicago ADALI, A , YİRÜN, A , KOÇER-GÜMÜŞEL, B , ERKEKOĞLU, P . "ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ". Journal of Faculty of Pharmacy of Ankara University 44 (2020 ): 167-187
RIS TY - JOUR T1 - ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ AU - Ayça ADALI , Anıl YİRÜN , Belma KOÇER-GÜMÜŞEL , Pınar ERKEKOĞLU Y1 - 2020 PY - 2020 N1 - doi: 10.33483/jfpau.523804 DO - 10.33483/jfpau.523804 T2 - Journal of Faculty of Pharmacy of Ankara University JF - Journal JO - JOR SP - 167 EP - 187 VL - 44 IS - 1 SN - 1015-3918-2564-6524 M3 - doi: 10.33483/jfpau.523804 UR - https://doi.org/10.33483/jfpau.523804 Y2 - 2019 ER -
EndNote %0 Ankara Üniversitesi Eczacılık Fakültesi Dergisi ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ %A Ayça ADALI , Anıl YİRÜN , Belma KOÇER-GÜMÜŞEL , Pınar ERKEKOĞLU %T ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ %D 2020 %J Journal of Faculty of Pharmacy of Ankara University %P 1015-3918-2564-6524 %V 44 %N 1 %R doi: 10.33483/jfpau.523804 %U 10.33483/jfpau.523804
ISNAD ADALI, Ayça , YİRÜN, Anıl , KOÇER-GÜMÜŞEL, Belma , ERKEKOĞLU, Pınar . "ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ". Journal of Faculty of Pharmacy of Ankara University 44 / 1 (Ocak 2020): 167-187 . https://doi.org/10.33483/jfpau.523804
AMA ADALI A , YİRÜN A , KOÇER-GÜMÜŞEL B , ERKEKOĞLU P . ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ. Ankara Ecz. Fak. Derg.. 2020; 44(1): 167-187.
Vancouver ADALI A , YİRÜN A , KOÇER-GÜMÜŞEL B , ERKEKOĞLU P . ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ. Journal of Faculty of Pharmacy of Ankara University. 2020; 44(1): 187-167.