Araştırma Makalesi
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BAZI NAFTOKİNON TÜREVLERİ İLE İLAÇ MADDELERİ ARASINDAKİ ETKİLEŞİM ÜRÜNLERİNİN YAPISININ İNCELENMESİ

Yıl 2021, Cilt: 45 Sayı: 2, 321 - 331, 31.05.2021
https://doi.org/10.33483/jfpau.835875

Öz

Amaç: Naftokinon esaslı analitik reaktiflerin asetilsistein, β-alanin ve taurin (2-aminoetanosülfonik asit) gibi farmasötik açıdan aktif maddelerle etkilişimin, oluşan ürünlerin ayırımı yapı oluşumu dahil olmak üzere detaylı incelemesidir.
Gereç ve Yöntem: Farmasötik maddeler ile naftokinon türevleri arasındaki reaksiyonlarda reaktanların stokiyometrik katsayılarını belirlemek için UV - Vis spektrofotometri yöntemi uygulandı. Reaksiyon ürünlerinin yapısını kanıtlamak için 1Н NMR-spektroskopi, IR spektroskopi, kütle spektrometrisi kullanıldı.
Sonuç ve Tartışma: Kinon türevleri ile araştırılan tıbbi maddelerin reaksiyonlarında reaktanların stokiyometrik ilişkileri, doyurma ve sürekli değişim yöntemleri ile belirlenmiştir. İlişki her durumda 1: 1'dir. Bileşen reaksiyonu ve reaksiyon yolu için optimal koşulların belirlenen ilişkilerine göre, asetilsisteinin 2,3-dikloro-1,4-naftokinon ve taurin ile, β-alanin ile sodyum 1,2-naftokinon-4-sülfonat ile etkileşim ürünleri izole edilmiş ve tanımlanmıştır. Bileşiklerin yapısını oluşturmak için 1Н NMR-spektroskopi, IR spektroskopisi, kütle spektrometrisi kullanılmıştır.

Kaynakça

  • 1. Abou-Ouf, A., Taha, A. M., Saidhom, M. (1973). Spectrophotometric analysis of primary aliphatic amines with dichlone. Journal of Pharmaceutical Sciences, 62(10), 1700-1702. doi:10.1002/jps.2600621028
  • 2. C. J. Shishoo, B. N. Suhagia, I. S. Rathod, S. S. Thakore. (1996). Spectrophotometric estimation of piperazine in dosage forms using Dichlone and Acetaldehyde as reagents. Indian Journal of Pharmaceutical Sciences, 58(6), 219-221.
  • 3. El-Yazbi, F. A., Abdine, H. H., Shaalan, R. A. (1999). Spectrophotometric and spectrofluorometric methods for the assay of lisinopril in single and multicomponent pharmaceutical dosage forms. Journal of Pharmaceutical and Biomedical Analysis, 19(6), 819-827. doi:10.1016/s0731-7085(98)00110-1
  • 4. Li, Q., Yang, Z. (2007). Spectrophotometric determination of aminomethylbenzoic acid using sodium 1,2-naphthoquinone-4-sulfonate as the chemical derivative chromogenic reagent. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 66(3), 656-661. doi:10.1016/j.saa.2006.04.007
  • 5. Xu, L., Wang, H., Xiao, Y. (2004). Spectrophotometric determination of ampicillin sodium in pharmaceutical products using sodium 1,2-naphthoquinone-4-sulfonic as the chromogentic reagent. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 60(13), 3007-3012. doi:10.1016/j.saa.2004.02.018
  • 6. Saurina, J., Hernández-Cassuo, S. (1993). Continuous-flow spectrophotometric determination of amino acids with 1,2-naphthoquinone-4-sulphonate reagent. Analytica Chimica Acta, 283(1), 414-420. doi:10.1016/0003-2670(93)85252-f
  • 7. Miedviedieva, K. P., Donchenko, А О, Vasiuk, S. O. (2019). Application of quinone derivatives for spectrophotometric determination of drugs. Current Issues in Pharmacy and Medicine: Science and Practice, 0(3). doi:10.14739/2409-2932.2019.3.184173
  • 8. Portnaya, E. P., Vasyuk, S. A. (2014). Spectrophotometric determination of taurine in dosage forms using sodium 1,2-naphthoquinone-4-sulfonate. Pharmaceutical Chemistry Journal, 48(8), 553-557. doi:10.1007/s11094-014-1150-3

STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES

Yıl 2021, Cilt: 45 Sayı: 2, 321 - 331, 31.05.2021
https://doi.org/10.33483/jfpau.835875

Öz

Objective: The purpose of the present work is to detail а study of the interaction between naphthoquinone-based analytical reagents and such pharmacologically active ingredients as acetylcysteine, β-alanine and taurine (2-aminoethanesulfonic acid) including the isolation and structure elucidation of the formed products.
Material and Method: UV-visible spectrophotometry was applied to determine the stoichiometric coefficients of reactants in reactions between the pharmaceutical substances and naphthoquinone derivatives. 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used to prove the structure of the reaction products.
Result and Discussion: The stoichiometric relationships of the reactants in the investigated medicinal substances reactions with quinone derivatives were determined by the methods of saturation and continuous changes. They are 1:1 in each case. According to the determined relationships of components reaction and optimal conditions for reactions path, the products of interaction of acetylcysteine with 2,3-dichloro-1,4-naphthoquinone and taurine, β-alanine with sodium 1,2-naphthoquinone-4-sulfonate were isolated and identified. In order to establish the structure of the compounds, the 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used.

Kaynakça

  • 1. Abou-Ouf, A., Taha, A. M., Saidhom, M. (1973). Spectrophotometric analysis of primary aliphatic amines with dichlone. Journal of Pharmaceutical Sciences, 62(10), 1700-1702. doi:10.1002/jps.2600621028
  • 2. C. J. Shishoo, B. N. Suhagia, I. S. Rathod, S. S. Thakore. (1996). Spectrophotometric estimation of piperazine in dosage forms using Dichlone and Acetaldehyde as reagents. Indian Journal of Pharmaceutical Sciences, 58(6), 219-221.
  • 3. El-Yazbi, F. A., Abdine, H. H., Shaalan, R. A. (1999). Spectrophotometric and spectrofluorometric methods for the assay of lisinopril in single and multicomponent pharmaceutical dosage forms. Journal of Pharmaceutical and Biomedical Analysis, 19(6), 819-827. doi:10.1016/s0731-7085(98)00110-1
  • 4. Li, Q., Yang, Z. (2007). Spectrophotometric determination of aminomethylbenzoic acid using sodium 1,2-naphthoquinone-4-sulfonate as the chemical derivative chromogenic reagent. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 66(3), 656-661. doi:10.1016/j.saa.2006.04.007
  • 5. Xu, L., Wang, H., Xiao, Y. (2004). Spectrophotometric determination of ampicillin sodium in pharmaceutical products using sodium 1,2-naphthoquinone-4-sulfonic as the chromogentic reagent. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 60(13), 3007-3012. doi:10.1016/j.saa.2004.02.018
  • 6. Saurina, J., Hernández-Cassuo, S. (1993). Continuous-flow spectrophotometric determination of amino acids with 1,2-naphthoquinone-4-sulphonate reagent. Analytica Chimica Acta, 283(1), 414-420. doi:10.1016/0003-2670(93)85252-f
  • 7. Miedviedieva, K. P., Donchenko, А О, Vasiuk, S. O. (2019). Application of quinone derivatives for spectrophotometric determination of drugs. Current Issues in Pharmacy and Medicine: Science and Practice, 0(3). doi:10.14739/2409-2932.2019.3.184173
  • 8. Portnaya, E. P., Vasyuk, S. A. (2014). Spectrophotometric determination of taurine in dosage forms using sodium 1,2-naphthoquinone-4-sulfonate. Pharmaceutical Chemistry Journal, 48(8), 553-557. doi:10.1007/s11094-014-1150-3
Toplam 8 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Anastasiia Donchenko 0000-0002-3511-1339

Kateryna Miedviedieva 0000-0001-7260-5728

Oleksii Voskoboınık Bu kişi benim

Svitlana Vasyuk Bu kişi benim 0000-0002-1569-9374

Serhii Kovalenko Bu kişi benim 0000-0001-8017-9108

Yayımlanma Tarihi 31 Mayıs 2021
Gönderilme Tarihi 4 Aralık 2020
Kabul Tarihi 18 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 45 Sayı: 2

Kaynak Göster

APA Donchenko, A., Miedviedieva, K., Voskoboınık, O., Vasyuk, S., vd. (2021). STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES. Journal of Faculty of Pharmacy of Ankara University, 45(2), 321-331. https://doi.org/10.33483/jfpau.835875
AMA Donchenko A, Miedviedieva K, Voskoboınık O, Vasyuk S, Kovalenko S. STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES. Ankara Ecz. Fak. Derg. Mayıs 2021;45(2):321-331. doi:10.33483/jfpau.835875
Chicago Donchenko, Anastasiia, Kateryna Miedviedieva, Oleksii Voskoboınık, Svitlana Vasyuk, ve Serhii Kovalenko. “STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES”. Journal of Faculty of Pharmacy of Ankara University 45, sy. 2 (Mayıs 2021): 321-31. https://doi.org/10.33483/jfpau.835875.
EndNote Donchenko A, Miedviedieva K, Voskoboınık O, Vasyuk S, Kovalenko S (01 Mayıs 2021) STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES. Journal of Faculty of Pharmacy of Ankara University 45 2 321–331.
IEEE A. Donchenko, K. Miedviedieva, O. Voskoboınık, S. Vasyuk, ve S. Kovalenko, “STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES”, Ankara Ecz. Fak. Derg., c. 45, sy. 2, ss. 321–331, 2021, doi: 10.33483/jfpau.835875.
ISNAD Donchenko, Anastasiia vd. “STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES”. Journal of Faculty of Pharmacy of Ankara University 45/2 (Mayıs 2021), 321-331. https://doi.org/10.33483/jfpau.835875.
JAMA Donchenko A, Miedviedieva K, Voskoboınık O, Vasyuk S, Kovalenko S. STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES. Ankara Ecz. Fak. Derg. 2021;45:321–331.
MLA Donchenko, Anastasiia vd. “STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES”. Journal of Faculty of Pharmacy of Ankara University, c. 45, sy. 2, 2021, ss. 321-3, doi:10.33483/jfpau.835875.
Vancouver Donchenko A, Miedviedieva K, Voskoboınık O, Vasyuk S, Kovalenko S. STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES. Ankara Ecz. Fak. Derg. 2021;45(2):321-3.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.