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PHARMACOPOEIA ANALYSIS OF NIOLI ESSENTIAL OIL PURCHASED FROM THE MARKET

Yıl 2024, Cilt: 48 Sayı: 1, 215 - 225, 20.01.2024
https://doi.org/10.33483/jfpau.1406371

Öz

Objective: The public's considerstion of natural resources as safe and the tendency not to use synthetic component-containing products have increased the use of essential oils recently. However, since essential oils contain a vast number of compounds, there are difficulties in standardization. For this reason, monographs are used to evaluate the quality of the essential oils and their use for therapeutic purposes. As a result of various studies, it has been shown that nioli essential oil can be used against upper respiratory tract and urinary tract infections and skin disorders and has antioxidant, anti-inflammatory, antiseptic, antifungal, antibacterial, anthelmintic, insecticidal, larvicidal and acaricidal activities. It is traditionally used against cold, influenza, cough, sinusitis, pharyngitis, rhinitis, rheumatic disorders and urinary system infections. Due to these activities and its traditional use; it is aimed to evaluate the compliance of some nioli essential oil samples available on the market with the Turkish Pharmacopoeia 2017.
Material and Method: In the content of this study; nioli essential oil samples of 5 different brands are analyzed according to the monograph given in Turkish Pharmacopoeia (2017). In the analysis; relative density, refractive index, optical rotation values were determined; organoleptic control, thin layer chromatography and gas chromatography analyzes were carried out.
Result and Discussion: As the result of the pharmacopoeia analysis conducted within the scope of the study, only one of the five nioli essential oil samples provided was found to comply with the pharmacopoeia standard. Other nioli essential oil samples did not meet the required conditions in the pharmacopoeia.

Kaynakça

  • 1. Bakkali, F., Averbeck, S., Averbeck, D., Idaomar, M. (2008). Biological effects of essential oils - A review. Food and Chemical Toxicology, 46(2), 446-475. [CrossRef]
  • 2. Shakeel, F., Salem-Bekhit, M.M., Haq, N., Alshehri, S. (2021). Nanoemulsification improves the pharmaceutical properties and bioactivities of niaouli essential oil (Melaleuca quinquenervia L.). Molecules, 26(16), 4750. [CrossRef]
  • 3. Burt, S. (2004). Essential oils: Their antibacterial properties and potential applications in foods - A review. International Journal of Food Microbiology, 94(3), 223-253. [CrossRef]
  • 4. Valkova, V., Duranova, H., Vukovic, N.L., Vukic, M., Kluz, M., Kacaniova, M. (2022). Assessment of chemical composition and anti-penicillium activity of vapours of essential oils from Abies Alba and two Melaleuca species in food model systems. Molecules, 27(10), 3101. [CrossRef]
  • 5. Fouyet, S., Olivier, E., Leproux, P., Dutot, M., Rat, P. (2022). Evaluation of placental toxicity of five essential oils and their potential endocrine-disrupting effects. Current Issues in Molecular Biology, 44(7), 2794-2810. [CrossRef]
  • 6. Erçin, E., Dincel, D. (2021). Sindirim Sistemi Hastalıklarında Aromaterapi, Türkiye Klinikleri, Ankara, p. 95-104.
  • 7. Ishfaq, P.M., Shukla, A., Beraiya, S., Tripathi, S., Mishra, S.K. (2018). Biochemical and pharmacological applications of essential oils in human health especially in cancer prevention. Anti-Cancer Agents in Medicinal Chemistry, 18(13), 1815-1827. [CrossRef]
  • 8. Truzzi, E., Marchetti, L., Benvenuti, S., Ferroni, A., Rossi, M.C., Bertelli, D. (2021). Novel strategy for the recognition of adulterant vegetable oils in essential oils commonly used in food industries by applying (13)C NMR spectroscopy. Journal of Agricultural Food Chemistry, 69(29), 8276-8286. [CrossRef]
  • 9. Do, T.K.T., Hadji-Minaglou, F., Antoniotti, S., Fernandez, X. (2015). Authenticity of essential oils. TrAC Trends in Analytical Chemistry, 66, 146-157. [CrossRef]
  • 10. Temel, M., Tınmaz A,B., Öztürk, M., Gündüz, O. (2018). Dünyada ve Türkiye’de tıbbi-aromatik bitkilerin üretimi ve ticareti. KSÜ Tarım ve Doğa Derg, 21(Özel Sayı), 198-214.
  • 11. Ng, T.B., Fang, E.F., Bekhit, A.E.D.A., Wong, J.H. (2016). Methods for the characterization, authentication, and adulteration of essential oils. In Essential Oils in Food Preservation, Flavor and Safety, 11-17. [CrossRef]
  • 12. Pino, O., Sanchez, Y., Rojas, M.M., Rodriguez, H., Abreu, Y., Duarte, Y., Martinez, B., Peteira, B., Correa, T.M., Martinez, D. (2011). Composicion qumica y actividad plaguicida del aceite esencial de Melaleuca quinquenervia (Cav) S.T. Blake. Rev Proteccion Veg, 26(3), 177-186.
  • 13. Türk Farmakopesi 2017. (2018). T.C. Sağlık Bakanlığı Yayınları p. 57-58.
  • 14. Tisserand, R., Young, R. (2014). Essential oil profiles. In Essential Oil Safety, 187-482. [CrossRef]
  • 15. Blumethal, M. (1998). The Complete German Commission E Monograph Therapeutic Guide to Herbal Medicines, Austin, Texas: The American Botanical Council, p. 174-175.
  • 16. Ramanoelina, P.A.R., Viano, J., Bianchini, J.P., Emile M. Gaydou, J.P. (1994). Occurrence of various chemotypes in niaouli (Melaleuca quinquenervia) essential oils from Madagascar using multivariate statistical analysis, p. 1177-1182.
  • 17. Trilles, B.L., Bombarda, I., Bouraïma-Madjebi, S., Raharivelomanana, P., Bianchini, J.P., Gaydou, E.M. (2006). Occurrence of various chemotypes in niaouli [Melaleuca quinquenervia (Cav.) S. T.Blake] essential oil from New Caledonia. Flavour and Fragrance Journal, 21(4), 677-682. [CrossRef]
  • 18. Siddique, S., Mazhar, S., Firdaus-e-Bareen, Parveen, Z. (2018). Chemical characterization, antioxidant and antimicrobial activities of essential oil from Melaleuca quinquenervia leaves. Indian Journal of Experimental Biology, 56(9), 686-693.
  • 19. Aumeeruddy-Elalfi, Z., Gurib-Fakim, A., Mahomoodally, M.F. (2016). Chemical composition, antimicrobial and antibiotic potentiating activity of essential oils from 10 tropical medicinal plants from Mauritius. Journal of Herbal Medicine, 6(2), 88-95. [CrossRef]
  • 20. Tančinová, D., Foltí­nová, D., Mašková, Z., Štefániková, J., Árvay, J. (2019). Effect of essential oils of Myrtaceae plants on the Penicillium commune. Potravinarstvo Slovak Journal of Food Sciences, 13(1), 604-613. [CrossRef]
  • 21. Onem, E., Soyocak, A., Muhammed, M.T., Ak, A. (2021). In Vitro and In Silico Assessment of the potential of niaouli essential oil as a quorum sensing inhibitor of biofilm formation and its effects on fibroblast cell viability. Brazilian Archives of Biology and Technology, 64. [CrossRef]
  • 22. Gaínza, Y.A., Domingues, L.F., Perez, O.P., Rabelo, M.D., López, E.R., Chagas, A.C.D.S. (2015). Anthelmintic activity in vitro of Citrus sinensis and Melaleuca quinquenervia essential oil from Cuba on Haemonchus contortus. Industrial Crops and Products, 76, 647-652. [CrossRef]
  • 23. Cilingir-Kaya, O.T., Gurler, E.B. (2022). Therapeutic potential of essential oil of Melaleuca quinquenervia (Myrtaceae) in a rat model of ethanol-induced peptic ulcer. Tropical Journal of Pharmaceutical Research, 20(5), 981-986. [CrossRef]
  • 24. Selçuk, B. (2020). Yüksek Lisans Tezi, Eczaneye Başvuran Hastaların Klinik Aromaterapiye Bakış Açısının Belirlenmesi Ve Klinik Eczacının Aromaterapi Uygulamalarındaki Rolü. Klinik Eczacılık Anabilim Dalı, İstanbul Medipol Üniversitesi, İstanbul, Türkiye, p.11.
  • 25. Yi, C.G., Choi, B.R., Park, H.M., Park, C.G., Ahn, Y.J. (2006). Fumigant toxicity of plant essential oils to Thrips palmi (Thysanoptera: Thripidae) and Orius strigicollis (Heteroptera: Anthocoridae). Journal of Economic Entomology, 99(5), 1733-1738. [CrossRef]
  • 26. Sim, M.J., Choi, D. R., Ahn, Y.J. (2006). Vapor phase toxicity of plant essential oils to Cadra cautella (Lepidoptera: Pyralidae). Journal of Economic Entomology, 99(2), 593-598.
  • 27. Özdemir, E., Aslan, İ., Çakıcı, B., Türker, B., Çelik, C.E., Kayhan, H. (2018). Microbiological property evaluation of natural essential oils used in green cosmetic industry. Curr Pers MAPs, 2, 111-116.
  • 28. Lee, Y.S., Kim, J., Shin, S.C., Lee, S.G., Park, I.K. (2008). Antifungal activity of Myrtaceae essential oils and their components against three phytopathogenic fungi. Flavour and Fragrance Journal, 23(1), 23-28. [CrossRef]
  • 29. Acha, E., Ahounou Aikpe, J.F., Adovelande, J., Assogba, M.F., Agossou, G., Sezan, A., Dansou, H.P., Gbenou, D.J. (2019). Anti-inflammatory properties of Melaleuca quinquenervia. International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 6(1), 30-40. [CrossRef]
  • 30. Valková, V., Ďúranová, H., Galovičová, L., Kačániová, M. (2020). Rosalina, Niaouli and Fir Essential Oils: Strong Antifungal but Weak Antioxidant Activity, p. 171-176.
  • 31. Andrade Santiago, J., Cardoso, M.D.G., Batista, L.R., Santiago, W.D., Passamani, F.R.F., Rodrigues, L.M.A., Nelson, D.L. (2018). Effect of the essential oils from Melaleuca alternifolia, Melaleuca quinquenervia and Backhousia citriodora on the synthesis of ochratoxin A by Aspergillus niger and Aspergillus carbonarius isolated from tropical wine grapes. Journal of Food Science and Technology, 55(1), 418-423. [CrossRef]
  • 32. Fernandes, L., Ribeiro, R., Costa, R., Henriques, M., Rodrigues, M.E. (2022). Essential oils as a good weapon against drug-resistant Candida auris. Antibiotics (Basel), 11(7), 977. [CrossRef]
  • 33. Monti, D., Najarro, M., Chetoni, P., Burgalassi, S., Saettone, M.F., Boldrini, E. (2006). Niaouli oil as enhancer for transdermal permeation of estradiol evaluation of gel formulations on hairless rats. Journal of Drug Delivery Science and Technology, 16(6), 473-476. [CrossRef]
  • 34. Parin, F.N., El-Ghazali, S., Yesilyurt, A., Parin, U., Ullah, A., Khatri, M., Kim, I.S. (2023). PVA/Inulin-based sustainable films reinforced with pickering emulsion of niaouli essential oil for potential wound healing applications. Polymers (Basel), 15(4), 1002. [CrossRef]
  • 35. Chao, W.W., Su, C.C., Peng, H.Y., Chou, S.T. (2017). Melaleuca quinquenervia essential oil inhibits alpha-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells. Phytomedicine, 34, 191-201. [CrossRef]
  • 36. Aygün Bilecik, N., Yaşa Öztürk, G. (2023). Could niaouli aromatherapy oil be an option in the treatment of urinary tract infections in hemiplegic patients? Anatolian Current Medical Journal, 5(1), 59-64. [CrossRef]
  • 37. Park, H.M., Kim, J., Chang, K.S., Kim, B.S., Yang, Y.J., Kim, G.H., Shin, S.C., Park, I.K. (2011). Larvicidal activity of Myrtaceae essential oils and their components against Aedes aegypti, acute toxicity on Daphnia magna, and aqueous residue. Journal of Medical Entomology, 48(2), 405-410. [CrossRef]
  • 38. Leyva, M., French-Pacheco, L., Quintana, F., Montada, D., Castex, M., Hernandez, A., Marquetti, M.D.C. (2016). Melaleuca quinquenervia (Cav.) S.T. Blake (Myrtales: Myrtaceae): Natural alternative for mosquito control. Asian Pacific Journal of Tropical Medicine, 9(10), 979-984. [CrossRef]
  • 39. Demirezer, L.Ö., Ersöz, T., Saraçoğlu, İ., Şener, B., Köroğlu, A., Yalçın, F.N. (2021). A’dan Z’ye Tıbbi Yağlar ve Aromatik Sular, Hayykitap, İstanbul, p.218.
  • 40. Demirci, B., Demirbolat, İ., Kartal, M. (2021). Aromaterapide Kullanılan Uçucu ve Sabit Yağların Kalite Kontrol Analizleri, Türkiye Klinikleri, Ankara, p.50-55.
  • 41. Ergene, B., Haddur, D., Karaaslan, M., İleri Özler, K.,Saltan İşcan, G. (2023). Piyasada bulunan bazı uçucu yağların farmakope uygunluğunun değerlendirilmesi. Ankara Eczacılık Fakültesi Dergisi, 47(1), 157-167.
  • 42. Özdemir, H.,Öztunç, G. (2013). Hemşirelik Uygulamalarında Aromaterapi. Türkiye Klinikleri Journal of Nursing Sciences, 98-104.

PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ

Yıl 2024, Cilt: 48 Sayı: 1, 215 - 225, 20.01.2024
https://doi.org/10.33483/jfpau.1406371

Öz

Amaç: Halk arasında doğal kaynakların güvenli olarak kabul edilmesi ve sentetik içerikli ürünlerden uzaklaşma isteği, uçucu yağ kullanımını son zamanlarda arttırmıştır. Fakat uçucu yağlar, içerisinde çok sayıda bileşik barındırdığından standardizasyon konusunda sıkıntılar yaşanmaktadır. Bu sebeple uçucu yağların kalitesini ve terapötik amaçla kullanılabilirliğini değerlendirmek için monograflardan yararlanılmaktadır. Yapılan çeşitli çalışmalar sonucunda nioli uçucu yağının; üst solunum yolu ve üriner sistem enfeksiyonlarına, cilt rahatsızlıklarına karşı kullanılabileceği ve antioksidan, antienflamatuvar, antiseptik, antifungal, antibakteriyel, antihelmintik, insektisidal, larvisidal ve akarisidal etkinliği tespit edilmiştir. Halk arasında ise soğuk algınlığı, influenza, öksürük, sinüzit, farenjit, rinit, romatizmal rahatsızlıklarda ve üriner sistem enfeksiyonlarında kullanılmaktadır. Bu etkinlikleri ve halk arasındaki kullanımından yola çıkılarak, piyasada bulunan bazı nioli uçucu yağ örneklerinin Türk Farmakopesi 2017’ye uygunluğunun değerlendirilmesi hedeflenmiştir.
Gereç ve Yöntem: Çalışma kapsamında; 5 farklı markadan temin edilen nioli uçucu yağı örneklerinin Türk Farmakopesi’nde (2017) yer alan monografa göre analiz edilmiştir. Analizde, bağıl yoğunluk, kırılım imleci, optik çevirme değerleri tespit edilmiş; organoleptik kontrol, ince tabaka kromatografisi ve gaz kromatografisi analizleri yürütülmüştür.
Sonuç ve Tartışma: Çalışma kapsamında yapılan farmakope analizi sonucunda, temin edilen beş nioli uçucu yağ numunesinden sadece bir tanesi farmakope standardına uygun olduğu bulunmuştur. Diğer nioli uçucu yağ numuneleri, farmakopede istenilen şartları karşılamamıştır.

Etik Beyan

Yazarlar bu çalışma için etik kurul onayının zorunlu olmadığını beyan etmektedir.

Destekleyen Kurum

Ankara Üniversitesi Eczacılık Fakültesi, TÜRKİYE BİLİMSEL VE TEKNOLOJİK ARAŞTIRMA KURUMU

Teşekkür

Yazarlar, çalışma kapsamında GC-MS analizlerine olanak sağlayan Anadolu Üniversitesi, Bitki, İlaç ve Bilimsel Araştırmalar Uygulama ve Araştırma Merkezi (AÜBİBAM)’ne teşekkürlerini sunarlar. Bu çalışma, TÜBİTAK 2209-A Üniversite Öğrencileri Araştırma Projeleri Destekleme Programı kapsamında desteklenmiştir.

Kaynakça

  • 1. Bakkali, F., Averbeck, S., Averbeck, D., Idaomar, M. (2008). Biological effects of essential oils - A review. Food and Chemical Toxicology, 46(2), 446-475. [CrossRef]
  • 2. Shakeel, F., Salem-Bekhit, M.M., Haq, N., Alshehri, S. (2021). Nanoemulsification improves the pharmaceutical properties and bioactivities of niaouli essential oil (Melaleuca quinquenervia L.). Molecules, 26(16), 4750. [CrossRef]
  • 3. Burt, S. (2004). Essential oils: Their antibacterial properties and potential applications in foods - A review. International Journal of Food Microbiology, 94(3), 223-253. [CrossRef]
  • 4. Valkova, V., Duranova, H., Vukovic, N.L., Vukic, M., Kluz, M., Kacaniova, M. (2022). Assessment of chemical composition and anti-penicillium activity of vapours of essential oils from Abies Alba and two Melaleuca species in food model systems. Molecules, 27(10), 3101. [CrossRef]
  • 5. Fouyet, S., Olivier, E., Leproux, P., Dutot, M., Rat, P. (2022). Evaluation of placental toxicity of five essential oils and their potential endocrine-disrupting effects. Current Issues in Molecular Biology, 44(7), 2794-2810. [CrossRef]
  • 6. Erçin, E., Dincel, D. (2021). Sindirim Sistemi Hastalıklarında Aromaterapi, Türkiye Klinikleri, Ankara, p. 95-104.
  • 7. Ishfaq, P.M., Shukla, A., Beraiya, S., Tripathi, S., Mishra, S.K. (2018). Biochemical and pharmacological applications of essential oils in human health especially in cancer prevention. Anti-Cancer Agents in Medicinal Chemistry, 18(13), 1815-1827. [CrossRef]
  • 8. Truzzi, E., Marchetti, L., Benvenuti, S., Ferroni, A., Rossi, M.C., Bertelli, D. (2021). Novel strategy for the recognition of adulterant vegetable oils in essential oils commonly used in food industries by applying (13)C NMR spectroscopy. Journal of Agricultural Food Chemistry, 69(29), 8276-8286. [CrossRef]
  • 9. Do, T.K.T., Hadji-Minaglou, F., Antoniotti, S., Fernandez, X. (2015). Authenticity of essential oils. TrAC Trends in Analytical Chemistry, 66, 146-157. [CrossRef]
  • 10. Temel, M., Tınmaz A,B., Öztürk, M., Gündüz, O. (2018). Dünyada ve Türkiye’de tıbbi-aromatik bitkilerin üretimi ve ticareti. KSÜ Tarım ve Doğa Derg, 21(Özel Sayı), 198-214.
  • 11. Ng, T.B., Fang, E.F., Bekhit, A.E.D.A., Wong, J.H. (2016). Methods for the characterization, authentication, and adulteration of essential oils. In Essential Oils in Food Preservation, Flavor and Safety, 11-17. [CrossRef]
  • 12. Pino, O., Sanchez, Y., Rojas, M.M., Rodriguez, H., Abreu, Y., Duarte, Y., Martinez, B., Peteira, B., Correa, T.M., Martinez, D. (2011). Composicion qumica y actividad plaguicida del aceite esencial de Melaleuca quinquenervia (Cav) S.T. Blake. Rev Proteccion Veg, 26(3), 177-186.
  • 13. Türk Farmakopesi 2017. (2018). T.C. Sağlık Bakanlığı Yayınları p. 57-58.
  • 14. Tisserand, R., Young, R. (2014). Essential oil profiles. In Essential Oil Safety, 187-482. [CrossRef]
  • 15. Blumethal, M. (1998). The Complete German Commission E Monograph Therapeutic Guide to Herbal Medicines, Austin, Texas: The American Botanical Council, p. 174-175.
  • 16. Ramanoelina, P.A.R., Viano, J., Bianchini, J.P., Emile M. Gaydou, J.P. (1994). Occurrence of various chemotypes in niaouli (Melaleuca quinquenervia) essential oils from Madagascar using multivariate statistical analysis, p. 1177-1182.
  • 17. Trilles, B.L., Bombarda, I., Bouraïma-Madjebi, S., Raharivelomanana, P., Bianchini, J.P., Gaydou, E.M. (2006). Occurrence of various chemotypes in niaouli [Melaleuca quinquenervia (Cav.) S. T.Blake] essential oil from New Caledonia. Flavour and Fragrance Journal, 21(4), 677-682. [CrossRef]
  • 18. Siddique, S., Mazhar, S., Firdaus-e-Bareen, Parveen, Z. (2018). Chemical characterization, antioxidant and antimicrobial activities of essential oil from Melaleuca quinquenervia leaves. Indian Journal of Experimental Biology, 56(9), 686-693.
  • 19. Aumeeruddy-Elalfi, Z., Gurib-Fakim, A., Mahomoodally, M.F. (2016). Chemical composition, antimicrobial and antibiotic potentiating activity of essential oils from 10 tropical medicinal plants from Mauritius. Journal of Herbal Medicine, 6(2), 88-95. [CrossRef]
  • 20. Tančinová, D., Foltí­nová, D., Mašková, Z., Štefániková, J., Árvay, J. (2019). Effect of essential oils of Myrtaceae plants on the Penicillium commune. Potravinarstvo Slovak Journal of Food Sciences, 13(1), 604-613. [CrossRef]
  • 21. Onem, E., Soyocak, A., Muhammed, M.T., Ak, A. (2021). In Vitro and In Silico Assessment of the potential of niaouli essential oil as a quorum sensing inhibitor of biofilm formation and its effects on fibroblast cell viability. Brazilian Archives of Biology and Technology, 64. [CrossRef]
  • 22. Gaínza, Y.A., Domingues, L.F., Perez, O.P., Rabelo, M.D., López, E.R., Chagas, A.C.D.S. (2015). Anthelmintic activity in vitro of Citrus sinensis and Melaleuca quinquenervia essential oil from Cuba on Haemonchus contortus. Industrial Crops and Products, 76, 647-652. [CrossRef]
  • 23. Cilingir-Kaya, O.T., Gurler, E.B. (2022). Therapeutic potential of essential oil of Melaleuca quinquenervia (Myrtaceae) in a rat model of ethanol-induced peptic ulcer. Tropical Journal of Pharmaceutical Research, 20(5), 981-986. [CrossRef]
  • 24. Selçuk, B. (2020). Yüksek Lisans Tezi, Eczaneye Başvuran Hastaların Klinik Aromaterapiye Bakış Açısının Belirlenmesi Ve Klinik Eczacının Aromaterapi Uygulamalarındaki Rolü. Klinik Eczacılık Anabilim Dalı, İstanbul Medipol Üniversitesi, İstanbul, Türkiye, p.11.
  • 25. Yi, C.G., Choi, B.R., Park, H.M., Park, C.G., Ahn, Y.J. (2006). Fumigant toxicity of plant essential oils to Thrips palmi (Thysanoptera: Thripidae) and Orius strigicollis (Heteroptera: Anthocoridae). Journal of Economic Entomology, 99(5), 1733-1738. [CrossRef]
  • 26. Sim, M.J., Choi, D. R., Ahn, Y.J. (2006). Vapor phase toxicity of plant essential oils to Cadra cautella (Lepidoptera: Pyralidae). Journal of Economic Entomology, 99(2), 593-598.
  • 27. Özdemir, E., Aslan, İ., Çakıcı, B., Türker, B., Çelik, C.E., Kayhan, H. (2018). Microbiological property evaluation of natural essential oils used in green cosmetic industry. Curr Pers MAPs, 2, 111-116.
  • 28. Lee, Y.S., Kim, J., Shin, S.C., Lee, S.G., Park, I.K. (2008). Antifungal activity of Myrtaceae essential oils and their components against three phytopathogenic fungi. Flavour and Fragrance Journal, 23(1), 23-28. [CrossRef]
  • 29. Acha, E., Ahounou Aikpe, J.F., Adovelande, J., Assogba, M.F., Agossou, G., Sezan, A., Dansou, H.P., Gbenou, D.J. (2019). Anti-inflammatory properties of Melaleuca quinquenervia. International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 6(1), 30-40. [CrossRef]
  • 30. Valková, V., Ďúranová, H., Galovičová, L., Kačániová, M. (2020). Rosalina, Niaouli and Fir Essential Oils: Strong Antifungal but Weak Antioxidant Activity, p. 171-176.
  • 31. Andrade Santiago, J., Cardoso, M.D.G., Batista, L.R., Santiago, W.D., Passamani, F.R.F., Rodrigues, L.M.A., Nelson, D.L. (2018). Effect of the essential oils from Melaleuca alternifolia, Melaleuca quinquenervia and Backhousia citriodora on the synthesis of ochratoxin A by Aspergillus niger and Aspergillus carbonarius isolated from tropical wine grapes. Journal of Food Science and Technology, 55(1), 418-423. [CrossRef]
  • 32. Fernandes, L., Ribeiro, R., Costa, R., Henriques, M., Rodrigues, M.E. (2022). Essential oils as a good weapon against drug-resistant Candida auris. Antibiotics (Basel), 11(7), 977. [CrossRef]
  • 33. Monti, D., Najarro, M., Chetoni, P., Burgalassi, S., Saettone, M.F., Boldrini, E. (2006). Niaouli oil as enhancer for transdermal permeation of estradiol evaluation of gel formulations on hairless rats. Journal of Drug Delivery Science and Technology, 16(6), 473-476. [CrossRef]
  • 34. Parin, F.N., El-Ghazali, S., Yesilyurt, A., Parin, U., Ullah, A., Khatri, M., Kim, I.S. (2023). PVA/Inulin-based sustainable films reinforced with pickering emulsion of niaouli essential oil for potential wound healing applications. Polymers (Basel), 15(4), 1002. [CrossRef]
  • 35. Chao, W.W., Su, C.C., Peng, H.Y., Chou, S.T. (2017). Melaleuca quinquenervia essential oil inhibits alpha-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells. Phytomedicine, 34, 191-201. [CrossRef]
  • 36. Aygün Bilecik, N., Yaşa Öztürk, G. (2023). Could niaouli aromatherapy oil be an option in the treatment of urinary tract infections in hemiplegic patients? Anatolian Current Medical Journal, 5(1), 59-64. [CrossRef]
  • 37. Park, H.M., Kim, J., Chang, K.S., Kim, B.S., Yang, Y.J., Kim, G.H., Shin, S.C., Park, I.K. (2011). Larvicidal activity of Myrtaceae essential oils and their components against Aedes aegypti, acute toxicity on Daphnia magna, and aqueous residue. Journal of Medical Entomology, 48(2), 405-410. [CrossRef]
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Ayrıntılar

Birincil Dil Türkçe
Konular Farmakognozi
Bölüm Araştırma Makalesi
Yazarlar

Burçin ERGENE 0000-0001-6927-6652

Gizem ÖZTÜRK 0009-0008-4175-776X

Proje Numarası 1919B012215189
Erken Görünüm Tarihi 31 Aralık 2023
Yayımlanma Tarihi 20 Ocak 2024
Gönderilme Tarihi 18 Aralık 2023
Kabul Tarihi 21 Aralık 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 48 Sayı: 1

Kaynak Göster

APA ERGENE, B., & ÖZTÜRK, G. (2024). PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ. Journal of Faculty of Pharmacy of Ankara University, 48(1), 215-225. https://doi.org/10.33483/jfpau.1406371
AMA ERGENE B, ÖZTÜRK G. PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ. Ankara Ecz. Fak. Derg. Ocak 2024;48(1):215-225. doi:10.33483/jfpau.1406371
Chicago ERGENE, Burçin, ve Gizem ÖZTÜRK. “PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ”. Journal of Faculty of Pharmacy of Ankara University 48, sy. 1 (Ocak 2024): 215-25. https://doi.org/10.33483/jfpau.1406371.
EndNote ERGENE B, ÖZTÜRK G (01 Ocak 2024) PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ. Journal of Faculty of Pharmacy of Ankara University 48 1 215–225.
IEEE B. ERGENE ve G. ÖZTÜRK, “PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ”, Ankara Ecz. Fak. Derg., c. 48, sy. 1, ss. 215–225, 2024, doi: 10.33483/jfpau.1406371.
ISNAD ERGENE, Burçin - ÖZTÜRK, Gizem. “PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ”. Journal of Faculty of Pharmacy of Ankara University 48/1 (Ocak 2024), 215-225. https://doi.org/10.33483/jfpau.1406371.
JAMA ERGENE B, ÖZTÜRK G. PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ. Ankara Ecz. Fak. Derg. 2024;48:215–225.
MLA ERGENE, Burçin ve Gizem ÖZTÜRK. “PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ”. Journal of Faculty of Pharmacy of Ankara University, c. 48, sy. 1, 2024, ss. 215-2, doi:10.33483/jfpau.1406371.
Vancouver ERGENE B, ÖZTÜRK G. PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ. Ankara Ecz. Fak. Derg. 2024;48(1):215-2.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.