Coenzyme Q10 Supplementation in Cardiovascular Diseases: Molecular Mechanisms and Clinical Evidence

Yıl 2025, Cilt: 7 Sayı: 2, 423 - 443, 25.08.2025

Merve Saruhan

Öz

Coenzyme Q10 (CoQ10) is a vitamin-like, lipophilic, redox-active molecule found naturally in all cell membranes, and it can be synthesized endogenously in all tissues. Its primary function is to support energy production by participating in the mitochondrial electron transport chain. Another well-known function of this molecule, which has many biochemical roles in the body, is its potent antioxidant properties, which protect against oxidative damage caused by reactive oxygen species. CoQ10 is abundant in tissues that require high energy, such as the heart muscle, and is considered a crucial component for maintaining heart health. Scientific studies suggest that CoQ10 supplementation may have beneficial effects in managing cardiovascular diseases, such as heart failure, coronary artery disease, hypertension, myocardial infarction, and dyslipidemia, where mitochondrial dysfunction and oxidative stress play a significant role in their pathogenesis. Recognized as a generally safe dietary supplement and one of the most widely used on the market, CoQ10 is considered a potential nutraceutical for supporting cardiovascular function and alleviating related symptoms.

Anahtar Kelimeler

Dietary Supplements , Energy Metabolism , Cardiovascular System , Coenzyme Q10 , Oxidative Stress.

Kardiyovasküler Hastalıklarda Koenzim Q10 Takviyesi: Moleküler Mekanizmalar ve Klinik Bulgular

Öz

Koenzim Q10 (CoQ10),tüm hücre zarlarında doğal olarak bulunan, tüm dokularda endojen olarak sentezlenebilen, vitamin benzeri lipofilik redoks-aktif bir moleküldür. Başlıca görevi mitokondriyal elektron taşıma sisteminde yer alarak enerji üretimini sağlamaktır. Vücutta birçok biyokimyasal fonksiyonları bulunan bu molekülün en iyi bilinen diğer fonksiyonu reaktif oksijen türlerinden kaynaklanan oksidatif hasardan koruyucu güçlü antioksidan özelliğidir. Kalp kasları gibi yüksek enerjiye ihtiyaç duyan dokularda bol miktarda bulunmakta olup, kalp sağlığının korunması için kritik bir bileşen olarak kabul edilmektedir. Bilimsel çalışmalar, CoQ10 takviyesinin patogenezlerinde mitokondriyal disfonksiyon ve oksidatif stresin önemli rol oynadığı kalp yetmezliği, koroner arter hastalığı, hipertansiyon, miyokard enfarktüsü, dislipidemi gibi kardiyovasküler hastalıkların yönetiminde olumlu etkiler gösterebileceğini ortaya koymaktadır. Genel olarak güvenli bir besin desteği olarak belirtilen ve piyasada en yaygın kullanılan besin takviyeleri arasında yer alan CoQ10, kardiyovasküler fonksiyonların desteklenmesi ve ilgili semptomların hafifletilebilmesi için potansiyel bir nütrasötik olarak değerlendirilmektedir.

Anahtar Kelimeler

Besin Destekleri , Enerji Metabolizması , Kardiyovasküler Sistem , Koenzim Q10 , Oksidatif Stres.

Kaynakça

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