Analysis Of Stage IIIB Endometrioid Type Endometrium Cancer: Experince Of Two Tertiary Oncology Center

Öz

Aim: The objective of this study was to analyzestage IIIB endometrioid type endometrial cancer.Material and Methods: This study was conducted in two gynecologic oncology centers between January 2007 and December 2016. Endometrial cancer was staged according to the International Federation of Gynecology and Obstetrics FIGO staging system and stage IIIB endometrioid type endometrial cancer patients were included in the study.The clinicopathologic findings of the patients were analyzed by reaching through the hospital database.Result: A total of 1700 endometrial cancer patients were investigated and of these patients, 10 were diagnosed with stage IIIB endometrioid type endometrial cancer. The median age of the patients were 62 years 49-85 and the median follow-upwas 45 months 20-93 . Four and four patients were diagnosed with vaginal involvement andparametrial involvement, respectively. Two patients were diagnosed withboth vaginal and parametrial involvement. Six 60% patients underwent radical hysterectomy and 4 40% patients underwent simple hysterectomy. Six patients received adjuvan chemotherapy. Only one patient received adjuvan pelvic radiotherapy whereas 3 patients received adjuvan vaginal brakitherapydue to advanced age. There were four recurrent cases.The five-year disease-freesurvival DFS rate and overall survival OS rate was 50% and 66.7%, respectively.Conclusion: Stage IIIB endometroid type endometrium cancer represents a rare specific subgroup of endometroid type endometrium cancer. As our knowledge this is the only study in the national literature. There is need for multi-center studies involving large number of patients.

Anahtar Kelimeler

• Endometrial cancer,stage IIIB,survival

Evre IIIB Endometrioid Tip Endometrium Kanser Olgularının Analizi: Tersiyer İki Onkolojik Merkez Deneyimi

Öz

Giriş: Bu çalışmanın amacı Evre IIIB endometrioid tip endometrium kanseri tanısı konulan olguları analiz etmektir.Gereç ve Yöntemler: Bu çalışma Ocak 2007-Aralık 2016 yılları arasında Uluslararası Obstetri ve Jinekoloji Federasyonu FIGO kriterlerine göre evre IIIB tanısı konulan hastaların dahil edildiği retrospektif iki merkezli bir çalışmadır. Olguların klinikopatolojik özellikleri kaydedilerek analiz edildi.Bulgular: Toplam 1700 endometrioid tip endometrium incelenmiş olup evre IIIB tanısı konulan 10 % 0,6 hasta tespit edildi. Olguların ortanca yaşı 62 49-85 , ortanca takip süresi ise 45 20-93 ay tespit edildi. Dört olguda vajinal, 4 olguda parametrium ve 2 olguda ise hem vajinal hem parametrial tutulum izlendi. Altı %60 olguya radikal histerektomi, 4 %40 olguya basit histerektomi yapıldı. Altı olguya adjuvan tedavi olarak kemoradyoterapi, 1 olguya sadece pelvik radyoterapi, yaşı ileri olan 3 olguya ise sadece vajinal brakiterapi verildi. Dört olguda nüks meydana geldi. Olguların 5 yıllık hastalıksız sağkalım DFS ve genel sağkalım OS oranı sıra ile %50 ve %66,7 olarak bulundu.Sonuç: Evre IIIB endometrioid tip endometrium kanseri nadir bir spesifik alt grubu temsil etmektedir. Bu çalışma ulusal literatürdeki tek çalışmadır. Daha geniş serili ve çok merkezli çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Endometrial kanser,evre IIIB,sağkalım

Kaynakça

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