Infertility Treatment Results In Hypogonadotropic Hypogonadism Cases

Öz

Aim: We aimed to determine the response to treatment of in vitro fertilization IVF / intracytoplasmic sperm injection ICSI on infertile female patients with hypogonadotropic hypogonadism HH .Material and Methods: 20 HH patients treated with IVF/ICSI in the period from 2009 until 2014 in Zeynep Kamil Women and Children Diseases Hospital IVF clinic were analyzed and compared with KOS / ICSI treatment results from 45 patients in our clinic in 2013 with unexplained infertility.Patients with low ovarian reserve were excluded. Follicular development, biochemical pregnancy, clinical pregnancy outcome, live birth outcomes were evaluated retrospectively.Results: The total dose of gonadotropin, implantation rate, grade 1-2 embryo rate and live birth rate was significantly higher in the HH group, while M2 oocytes number, the number of fertilized oocytes and fertilization rate was significantly higher in Uİ group. Serum estradiol level on the day of HCG, the collected total number of oocytes, oocyte ratio of M2, the number of Grade 1-2 embryos, number of embryos transferred were similar in both groups.Conclusions: In our study we concluded that HH patients respond well on treatment of IVF/ICSI as assisted reproductive techniques and successful reproductive outcomes can be obtained with high doses of gonadotropin therapy.

Anahtar Kelimeler

• Hypogonadotropic hypogonadism,infertility,assisted reproductive techniques

Hipogonadotropik Hipogonadizm Olgularında İnfertilite Tedavisi Sonuçları

Öz

Amaç: Hipogonadotropik hipogonadizmi HH bulunan infertil kadın hastaların kontrollü ovaryan stimulasyon KOS /intrasitoplazmik sperm injeksiyonu ICSI tedavisine verdikleri cevabı saptamayı amaçladık.Gereç ve Yöntemler: Bu çalışmaya 2009- 2014 tarihleri arasında Zeynep Kamil Kadın ve Çocuk Hastalıkları Hastanesi’nde tüp bebek kliniğindeKOS/ICSI tedavisi yapılmış 20 HH tanısı alan bayan hasta dahil edildi.Kontrol grubu olarak, kliniğimizde açıklanamayan infertilite Aİ nedeniyle 2013 yılında KOS/ICSI tedavisi yapılmış ardışık 45 hasta dahil edildi. Düşük ovaryan rezervi olan hastalar çalışma dışı bırakıldı. Retrospektif olarak folikül gelişimleri, biyokimyasal gebelik, klinik gebelik sonuçları, canlı doğum sonuçları değerlendirildi.Bulgular: HH grubunda toplam gonadotropin dozu, Grade 1-2 embriyo oranı, implantasyon oranı ve canlı doğum oranı anlamlı olarak yüksek bulunmuş, Aİ grubunda ise M2 oosit sayısı, fertilize oosit sayısı ve fertilizasyon oranı anlamlı olarak yüksek bulunmuştur. Her iki grupta; HCG günü serum östradiol değeri, toplanan toplam oosit sayısı, M2 oosit oranı, Grade 1-2 embriyo sayısı, transfer edilen embriyo sayısı benzer olarak bulunmuştur.Sonuç: Çalışmamızda HH nedeniyle yardımcı üreme tekniği olarak ICSI uygulanan hastalar incelenip KOH tedavisine iyi yanıt verdikleri veyüksek doz gonadotropin tedavileri ile başarılı reprodüktif sonuçlar elde edilebileceği sonucuna varılmıştır.

Anahtar Kelimeler

• Hipogonadotropik hipogonadizm,infertilite,yardımcı üreme teknikleri

Kaynakça

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