The effect of Chorioamnionitis on Perinatal and Neonatal Outcomes

Öz

Preterm birth is a one of the important causes of neonatal morbidity and mortality. Chorioamnionitis is a major risk factor of preterm birth. Due to heterogeneity between studies are difficult to evaluate the neonatal outcome. In addition, due to improvements in perinatal and neonatal care over the years the effects of chorioamnionitis on neonatal outcomes have become less evident. Histologic chorioamnionitis is associated with a reduction of incidence and severity of respiratory distress syndrome. However, eventually contributing to an increased risk of bronchopulmonary dysplasia. Also chorioamnionitis has been shown a risk factor for neonatal sepsis, cystic periventricular leukomalacia, white matter disease, cerebral palsy, and intraventricular hemorrhage.

Anahtar Kelimeler

• Chorioamnionitis,prematurity

Koryoamniyonitin Perinatal ve Neonatal Sonuçlar Üzerine Etkisi

Öz

Prematüre doğum neonatal morbidite ve mortalitenin en önemli nedenlerinden biridir. Koryoamniyonit spontan prematüre doğum için majör risk faktörüdür. Çalışmalar arasındaki heterojenlik nedeniyle neonatal sonuçların değerlendirilmesi zordur. Yıllar içinde perinatal ve neonatal bakımdaki iyileşmeler nedeniyle koryoamniyonitin neonatal sonuçlar üzerine etkisi de daha az belirgin hale gelmiştir. Histolojik koryoamniyonit respiratuar distres sendromunun sıklık ve şiddetinin azalması ile ilişkilidir. Bununla birlikte uzun dönemde bronkopulmoner displazi sıklığını arttırmaktadır. Ayrıca koryoamniyonit erken neonatal sepsis, kistik periventriküler lökomalazi, beyaz cevher hasarı, serebral palsi ve intraventriküler hemoraji için bir risk faktörüdür.

Anahtar Kelimeler

• Koryoamniyonit,prematürite

Kaynakça

1. Tita AT, Andrews WW. Diagnosis and management of clinical chorioam- nionitis. Clin Perinatol. 2010;37:339-54.
2. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and pre- term delivery. N Engl J Med 2000;342:1500-1507.
3. Czikk MJ, McCarthy FP, Murphy KE. Chorioamnionitis: from pathogene- sis to treatment. Clin Microbiol Infect 2011;17:1304-1311.
4. Romero R, Espinoza J, Gonçalves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25:21-39.
5. Redline RW. Inflammatory response in acute chorioamnionitis. Semin Fetal Neonatal Med. 2012;17:20-5.
6. Thomas W, Speer CP. Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome? Neonatology 2011;99:177-187.
7. Rovira N, Alarcon A, Iriondo M, Ibañez M, Poo P, Cusi V, Agut T, Pertierra A, Krauel X. Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. Early Hum Dev. 2011;87:253-7.
8. Galinsky R, Polglase GR, Hooper SB, Black MJ, Moss TJ. The consequ- ences of chorioamnionitis: preterm birth and effects on development. J Pregnancy. 2013;2013:412831.

9. Bersani I, Thomas W, Speer CP. Chorioamnionitis--the good or the evil for neonatal outcome? J Matern Fetal Neonatal Med. 2012;25:12-6.
10. Erdemir G, Kultursay N, Calkavur S, Zekioğlu O, Koroglu OA, Cakmak B, Yalaz M, Akisu M, Sagol S. Histological chorioamnionitis: effects on pre- mature delivery and neonatal prognosis. Pediatr Neonatol. 2013;54:267- 74.
11. Alexander JM, McIntire DM, Leveno KJ. Chorioamnionitis and the prog- nosis for term infants. Obstet Gynecol. 1999;94:274-8.
12. D’Alquen D1, Kramer BW, Seidenspinner S, Marx A, Berg D, Groneck P, Speer CP. Activation of umbilical cord endothelial cells and fetal inflam- matory response in preterm infants with chorioamnionitis and funisitis. Pediatr Res. 2005;57:263-9.
13. Hofer N, Kothari R, Morris N, Müller W, Resch B. The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates. Am J Obstet Gynecol. 2013;209:542 1-11.
14. Kim CJ, Yoon BH, Romero R, Moon JB, Kim M, Park SS, Chi JG. Umbili- cal arteritis and phlebitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol. 2001;185:496-500.
15. Agrawal V, Hirsch E. Intrauterine infection and preterm labor. Semin Fetal Neonatal Med. 2012;17:12-9.
16. Lahra MM, Beeby PJ, Jeffery HE. Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study. Pedi- atrics. 2009;123:1314-9.
17. Hendson L, Russell L, Robertson CM, Liang Y, Chen Y, Abdalla A, La- caze-Masmonteil T. Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. J Pediatr. 2011;158:397-402.
18. Strunk T, Doherty D, Jacques A, Simmer K, Richmond P, Kohan R, Char- les A, Burgner D. Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants. Pediatrics. 2012;129:e134- 41.
19. Speer CP. Neonatal respiratory distress syndrome: an inflammatory dise- ase? Neonatology. 2011;99:316-9.
20. Arayici S, Kadioglu Simsek G, Oncel MY, Eras Z, Canpolat FE, Oguz SS, Uras N, Zergeroglu S, Dilmen U. The effect of histological chorioam- nionitis on the short-term outcome of preterm infants ≤32 weeks: a single-center study. J Matern Fetal Neonatal Med. 2014;27:1129-33.
21. Watterberg KL, Demers LM, Scott SM, Murphy S. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics. 1996;97:210-5.
22. Viscardi RM. Perinatal inflammation and lung injury. Semin Fetal Neona- tal Med. 2012;17:30-5.
23. Been JV, Rours IG, Kornelisse RF, Jonkers F, de Krijger RR, Zimmermann LJ. Chorioamnionitis alters the response to surfactant in preterm infants. J Pediatr. 2010;156:10-15.
24. Ikegami T, Tsuda A, Karube A, Kodama H, Hirano H, Tanaka T. Effects of intrauterine IL-6 and IL-8 on the expression of surfactant apoprotein mR- NAs in the fetal rat lung. Eur J Obstet Gynecol Reprod Biol. 2000;93:97- 103.
25. Prince LS, Okoh VO, Moninger TO, Matalon S. Lipopolysaccharide inc- reases alveolar type II cell number in fetal mouse lungs through Toll-li- ke receptor 4 and NF-kappa B. Am J Physiol Lung Cell Mol Physiol. 2004;287:L999-1006.
26. Kramer BW, Moss TJ, Willet KE, Newnham JP, Sly PD, Kallapur SG, Ike- gami M, Jobe AH. Dose and time response after intraamniotic endotoxin in preterm lambs. Am J Respir Crit Care Med. 2001;164:982-8.
27. Kallapur SG, Bachurski CJ, Le Cras TD, Joshi SN, Ikegami MJobe AH. Vascular changes after intra-amniotic endotoxin in preterm lamb lung. Am J Physiol. 2004;287:L1178-85.
28. Willet KE, Jobe AH, Ikegami M, Newnham J, Brennan S, Sly PD. Antena- tal endotoxin and glucocorticoid effects on lung morphometry in preterm lambs. Pediat Research. 2000;48:782-8.
29. Hartling L, Liang Y, Lacaze-Masmonteil T. Chorioamnionitis as a risk fa- ctor for bronchopulmonary dysplasia: a systematic review and meta-a- nalysis. Arch Dis Child Fetal Neonatal Ed. 2012;97:8-17.
30. Viscardi RM, Manimtim WM, Sun CC, Duffy L, Cassell GH. Lung patho- logy in premature infants with Ureaplasma urealyticum infection. Pediatr Dev Pathol. 2002;5:141-50.
31. Viscardi RM, Atamas SP, Luzina IG, Hasday JD, He JR, Sime PJ, Coalson JJ, Yoder BA. Antenatal Ureaplasma urealyticum respiratory tract infe- ction stimulates proinflammatory, profibrotic responses in the preterm baboon lung. Pediatr Res. 2006;60:141-6.
32. Schelonka RL, Katz B, Waites KB, Benjamin DK Jr. Critical appraisal of the role of Ureaplasma in the development of bronchopulmonary dyspla- sia with metaanalytic techniques. Pediatr Infect Dis J. 2005;24:1033-9.
33. Wu YW. Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev. 2002;8:25-9.
34. Nitsos I, Rees SM, Duncan J, Kramer BW, Harding R, Newnham JP, Moss TJ. Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain. J Soc Gynecol Investig. 2006;13:239-47.
35. Yanowitz TD, Jordan JA, Gilmour CH, Towbin R, Bowen A, Roberts JM, Brozanski BS. Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentra- tions. Pediatr Res. 2002;51:310-6.
36. Leviton A, Allred EN, Kuban KC, Hecht JL, Onderdonk AB, O’shea TM, Paneth N. Microbiologic and histologic characteristics of the extremely preterm infant’s placenta predict white matter damage and later cerebral palsy. the ELGAN study. Pediatr Res. 2010;67:95-101.
37. Shatrov JG, Birch SC, Lam LT, Quinlivan JA, McIntyre S, Mendz GL. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol. 2010;116:387-92.
38. Kaukola T, Herva R, Perhomaa M, Paakko E, Kingsmore S, Vainionpaa L, Hallman M. Population cohort associating chorioamnionitis, cord inf- lammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants. Pediatr Res. 2006;59:478-83.
39. Suspiej A, Franzoi M, Vedovato S, Marucco A, Chiarelli S, Zenardo V. Neurodevelopmental outcome in preterm histological chorioamnionitis. Early Hum Dev. 2009;85:187-9.
40. Limperopoulos C, Bassan H, Sullivan NR, et al. Positive screening for autism in ex-preterm infants: prevalence and risk factors. Pediatrics. 2008;121:758-65.
41. Ylijoki M, Ekholm E, Haataja L, Lehtonen L; PIPARI study group. Is chori- oamnionitis harmful for the brain of preterm infants? A clinical overview. Acta Obstet Gynecol Scand. 2012;91:403-19.
42. Lee J, Dammann O. Perinatal infection, inflammation, and retinopathy of prematurity. Semin Fetal Neonatal Med. 2012;17:26-9.
43. Woo SJ, Park KH, Jung HJ, Kim Sn, Choe G, Ahn J, Park KH. Effects of maternal and placental inflammation on retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2012;250:915-23.
44. Liu PM, Fang PC, Huang CB, Kou HK, Chung MY, Yang YH, Chung CH. Risk factors of retinopathy of prematurity in premature infants weighing less than 1600 g. Am J Perinatol. 2005;22:115-20.
45. Bharwani SK, Dhanireddy R. Systemic fungal infection is associated with the development of retinopathy of prematurity in very low birth weight infants: a meta-review. J Perinatol. 2008;28:61-6.
46. Been JV, Lievense S, Zimmermann LJ, Kramer BW, Wolfs TG. Chorioam- nionitis as a risk factor for necrotizing enterocolitis: a systematic review and meta-analysis. J Pediatr. 2013;162:236-42.
47. Giannone PJ, Nankervis CA, Richter JM, Schanbacher BL, Reber KM. Prenatal lipopolysaccharide increases postnatal intestinal injury in a rat model of necrotizing enterocolitis. J Pediatr Gastroenterol Nutr. 2009;48:276-82.
48. Been JV, Rours IG, Kornelisse RF, Lima Passos V, Kramer BW, Schneider TA, de Krijger RR, Zimmermann LJ. Histologic chorioamnionitis, fetal involvement, and antenatal steroids: effects on neonatal outcome in pre- term infants. Am J Obstet Gynecol. 2009;201:5871-8.
49. Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006:CD004454.