The Comparison Of Maternal Serum D-Dimer And Fibrinogen Levels In Intrauterine Growth Retardation And Normal Fetal Development

Öz

Aim: To find out whether maternal serum D-dimer and fibrinogen measurements may have a role in the prediction of intrauterine growth restriction IUGR Material and Method: This study was carried out at Zekai Tahir Burak Women Health Education and Research Hospital between January 2011 and December 2011.Study included 117 women with IUGR at Perinatology Clinic and 117 pregnant women from antenatal policlinics at low risk. Patients age ranged from 18 to 40 and gestational ape ranged from 28 to 40 weeks. Patients sonographic measurements and maternal serum D-dimer and fibrinogen levels were recorded. Statistical evaluation was carried out by SPSS İllinois, Chicago, version 15 with appropriate tests. p

Anahtar Kelimeler

• IUGR,d-dimer,fibrinogen,intravascular coagulation

İntrauterin Gelişme Geriliğinde Ve Normal Fetal Gelişimde Gebe Serumlarında D-Dimer Ve Fıbrınojen Düzeylerinin Karşılaştırılması

Öz

Amaç: Çalışmamızın amacı intrauterin gelişme geriliğinde IUGG maternal serum D-dimer ve fibrinojeninin IUGG' yi öngörmedeki yerini belirlemektir.Gereçler ve Yöntem: Çalışma Ocak 2011 –Aralık 2011 tarihleri arasında Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi'nde değerlendirilen toplam 234 gebede yürütüldü. Hasta grubunu, Perinatoloji Kliniğinde yatmakta olan IUGG tanısı almış 117 hasta, kontrol grubunu ise antenatal takipteki düşük riskli 117 gebe oluşturdu. Gebelerin yaşları 18-40 arasında, gebelik haftaları 28-40. arasında değişmekte idi. Bu hastaların sonografik değerlendirmeleri yapılarak serumlarında Ddimer ve fibrinojen düzeyleri ölçüldü. İstatistiksel değerlendirme, SPSS programında Chicago, İllınoıs 15.versiyon programında uygun testler seçilerek yapıldı. p

Anahtar Kelimeler

• IUGG,D-dimer,fibrinojen,intravasküler koagülasyon

Kaynakça

1. 1.Baschat AA, Hecher K. Fetal growth restriction due to placental disease. Semin Perinatol 2004;28:67– 80
2. 2.Wolfe HM, Gross TL, Sokol RJ.Recurrent small for gestational age birth: perinatal risks and outcomes. Am J Obstet Gynecol 1987,157(2): 288-93
3. 3.Gardosi j,Mul T,Mongelli M,Fagan D. Am J Obstet Gynecol. 1987 Aug;157(2):288-93.Analysis of birthweight and gestational age in antepartum stillbirths .Br J Obstet Gynaecol 105:524,1998.
4. 4.Manning FA,Hohler C.Intrauterin growth retardation:diagnosis, prognostication and management based on ultrasound methods .Sayfa 331.In Fleischer AC,Romero R,Manning FA et al (eds). The Principles and Practical of Ultrasonography in Obstetrics and Gynecology.Appleton and Lange,Norwalk,1991
5. 5.Clausson B et al: Perinatal outcome in SGA births defined by customized versus population-based birthweigth standarts. Br J Obstet Gynaecol 2001; 108:830
6. 6.Kennelly M M, Farah N, Turner M J and Stuart B. Aortic isthmus Doppler velocimetry: role in assessment of preterm fetal growth restriction. Prenat Diagn 2010; 30: 395–401
7. 7.Liu J, Yuan E, Lee L.Gestational age-specific reference intervals for routine haemostatic assays during normal pregnancy. Clin Chim Acta 2012 Jan 18;413(1-2):258-61.
8. 8.Gatti L, Tenconi PM, Guarneri D, Bertulessi C, Ossola MW, Bosco P, Gianotti GA.Hemostatic parameters and platelet activation by flowcytometry in normal pregnancy: a longitudinal study. Int J Clin Lab Res 1994;24(4):217-9.

9. 9.Haliloglu B, Aksungar FB, Celik A, Ilter E, Coksuer H, Ozekici U.Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period: a prospective study. Eur J Obstet Gynecol Reprod Biol 2010 Nov;153(1):23-6.
10. 10.Francalanci I, Comeglio P, Liotta AA, Cellai AP, Fedi S, Parretti E, Mello G, Prisco D, Abbate R.D-Dimer in intra-uterine growth retardation and gestational hypertension. Thromb Res 1995 Oct 1;80(1):89-92
11. 11.Koh SC, Anandakumar C, Biswas A. Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome. J Perinat Med 1999;27(6):458-64
12. 12.Kessler CM, Bell WR. The effect of homologous thrombin and fibrinogen degradation products on fibrinogen synthesis in rabbits. J Lab Clin Med 1979 May;93(5):768-82.
13. 13.Bonnar J, McNicol GP, Douglas AS. Coagulation and fibrinolytic systems in pre-eclampsia and eclampsia. Br Med J 1971 Apr 3;2(5752)