Araştırma Makalesi
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Yıl 2020, Cilt: 17 Sayı: 1, 262 - 265, 31.03.2020

Öz

Destekleyen Kurum

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Proje Numarası

Okmeydanı Eğitim ve Araştırma Hastanesi -Uzmanlık Tezi 2007-1a

Teşekkür

Dear Editor, The manuscript entitled “Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes” has been submitted to the Jinekoloji-ObstetrikveNeonatolojiTıpDergisi. This study which was derived from the medical specialty thesis aims to compare the placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test for the prediction of rupture of membranes (ROM) in women with known and unknown rupture status. Although the study period is not recent, the most update literature data have been reviewed and the manuscript has been edited by a professional language editing service. Based on the study results, the PAMG-1 is a more accurate biomarker in patients with both known and unknown status of ROM than IGFBP-1 and nitrazine. Using this test rather than conventional methods may be helpful for early detection of ROM and positively affect the outcome of maternal and fetal health, as management of ROM can be performed in a timely manner, once the diagnosis is confirmed. The author herein certifies that he has no commercial, proprietary, or financial interest in the products or companies described in the manuscript. The author did not receive grants or a consultant honorarium to conduct the study, write the manuscript, or otherwise assist in the development of the aforementioned manuscript. The manuscript has been read and approved by the author. This manuscript has not been previously published or submitted for consideration to another journal or accepted for publication. In consideration of reviewing and editing submission, the author undersigned transfers, assigns and, otherwise, conveys all copyright ownership to theJinekoloji-ObstetrikveNeonatolojiTıpDergisi. Kindly submitted for your consideration for publication. Yours sincerely, Alparslan Deniz, MD Private Obstetrics and Gynecology Clinic, Manavgat, Antalya, TURKEY Tel: + 90 (242) 743 23 23 E-mail: dralparslandeniz@gmail.com

Kaynakça

  • 1. Dayal S, Hong PL; Premature rupture of membranes. StatPearls(internet).Treasure Island(FL): StatPearls Publishing:2018 Jan-2018 Dec 6.
  • 2. Sae-Lin P, Wanitpongpan P. İncidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital. J ObstetGynaecol Res. 2018 Dec 11.doi:10.1111/jog.13886
  • 3. Hanke K, Hartz A Manz M, Bendiks M etal. Preterm prelabor rupture of membranes and outcome of very-low-birthweight infants in the German Neonatal Network.PLoS One. 2015 Apr 9;10(4).
  • 4. Dera A, Breborowics GH, Keith L. Twin pregnancy - physiology, complications and the mode of delivery. Archives of Perinatal Medicine 2007;13(3):7-16.
  • 5. Mercer BM, Goldenberg RL, Meis PJ, et al. The Preterm Prediction Study: prediction of preterm premature rupture of membranes through clinical findings and ancillary testing. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J ObstetGynecol2000;183:738-45
  • 6. Vintzilleous AM, Wirston WA, Nochimson DJ et al. Degree of oligohydramnios and pregnancy outcome in patients with premature rupture of membranes. ObstetGynecol1985;66:162-7
  • 7. Trentacoste SV, Jean-Pierre C, Baergen R, Chasen ST. Outcomes of preterm premature rupture of membranes in twin pregnancies. J Matern Fetal Neonatal Med. 2008 Aug;21(8):555-7.
  • 8. Aris IM, Logan S, Lim C, Choolani M et al.Pretermprelabor rupture of membranes; a retrospective cohort studyof association with adverse outcome in subsequent pregnancy.BJOG. 2017 Oct;124(11):1698-1707
  • 9. Esteves JS, de SaRA, de Carvalho PR, Coca Velarde LG. Neonatal outcome in women with preterm premature rupture of membranes (PPROM) betwen 18and 26 weeks. Maternal Fetal Neonatal Med. 2016;29(7):1108-12
  • 10. Verspyck E, Bisson V, Roman H, Marret S (2014) Adverse respiratory outcome after premature rupture of membranes before viability. ActaPaediatr 103: 256–61.
  • 11. Williams O, Hutchings G, Hubinont C, Debauche C, Greenough A (2012) Pulmonary effects of prolonged oligohydramnios following mid-trimester rupture of the membranes—antenatal and postnatal management. Neonatology 101: 83–90.
  • 12. Gratacos E, Fıgureas F, Barranco M, et al. Spontaneous recovery of bacterial vaginosis during pregnancy is not associated with an improved perinatal outcome. ActaObstetGynecolScand1988;77:37-40
  • 13. Draper D, McGregor J, Hall J et al. Elevated protease activities in human amnion and chorion correlate with preterm premature rupture of membranes. Am J of ObstetGynecol1995;173:1506-12.
  • 14. Mercer BM, Goldenberg RL, Das A et al. The preterm prediction study: A clinical risk assessment system. Am J of ObstetGynecol1996;174:1885-95.
  • 15. Spinillo A, Capuzzo e, Piazzi G, et al. Risk for spontaneous preterm delivery by combined body mass index and gestational weight gain patterns. Am J ObstetGynecolScand1998;77:32-36.
  • 16. Kişnişçi, Gökşin, Durukan, Üstay, Ayhan, Gürgan, Önderoğlu. Temel Kadın HastalıklarıveDoğum Bilgisi.1481-1489, 1996.
  • 17. Waters TP, Mercer B. Preterm PROM: prediction, prevention, principles. ClinObstet Gynecol2011; 54: 307– 12.
  • 18. Parry S, Strauss JF. Premature rupture of fetal membranes. N Engl J Med 1998;338:663-70.
  • 19. McGregor JA, Johnson S. ’Fig-Leaf’ ferning and positive nitrazine testing: semen as a cause of misdiagnosis of premature rupture of membranes. Am J ObstetGynecol1985;151:1142-43
  • 20. de Han HH, Offermans PM, Smits F, Schouten HJ, Peeters LL. Value of the fern test to confirm or reject the diagnosis of ruptured membranes in modest in nonlaboring women presenting with nonspecific vaginal fluid loss. Am J Perinatol 1994; 11: 46-50
  • 21. Gaucherant P, Salle B, Sergeant P, et al. Comparative study of three vaginal markers of the premature rupture of membranes. Insulin lıke growth factor binding protein-1, daimine-oxidase, and pH.ActaObstetGynecol Scant 1997; 76: 536- 40
  • 22. Darj E, Lyrenas S. Insulin like growth factor binding-1, a quick way to detect amniotic fluid. ActaObstetGynecolScand 1998;77/3:295-7.
  • 23. Tatarinov YS, Kozljaeva GA, Petrunin DD, Petrunin YA. Two new human placenta-specıfıc α-globulins: Identification, purification, characteristics, cellular localization and clinical investigation. Serono Symposium No.35, ‘The Human Placenta’, edited by Kiopper A, Genazzani A, Crosignani PG. Academic Press, London and New York 1980;p:35-46.
  • 24. Ramsauer V, Duwe W, Schlehe B, Pitts R, Wagner D, Wutkewicz K, Chuvashkin D, Abele H, and Lachmann R. Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests. J. Perinat. Med. 2015 Jul;43(4):417-22.
  • 25. Abdelazim IA, Makhlouf HH. Placental alpha microglobulin-1 for detection of premature rupture of fetal membranes. Arch Gynecol Obstet. 2012 Apr;285(4):985-9
  • 26. Jeurgen-Borst AJ, Bekkers RL, Sporken JM, van den Berg PP. Use of insulin-like growth factor binding-1 in the diagnosis of ruptured fetal membranes. Eur J ObstetGynecolReprodBiol2002;10:102(1):11-4
  • 27. Lecerf M, Vardon D, Morello R, Lamendour N, Dreyfus M. Comparison of diagnostic performance of two tests of premature rupture of membranes (IGFP-1/PAMG-1) in clinical practice. J GynecolObstetBiolReprod (paris). 2015 Nov;44(9):832-9
  • 28. Igbinosa I, Moore III F.A,Johnson C, Block C.J. Comparison of rapid immunoassays for rupture of fetal membranes.BMCPregnanacy and Childbirth 2017;17:128
  • 29. Cousins LM, Smok DP, Lovett SM, Poeltler DM.AmniSure placental alpha microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes.Am J Perinatol2005 Aug;22(6):317-20.

Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes

Yıl 2020, Cilt: 17 Sayı: 1, 262 - 265, 31.03.2020

Öz

Objective: This study aims to compare the placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test for the prediction of rupture of membranes (ROM) in women with known and unknown rupture status.
Methods: This prospective study included a total of 90 patients with known and unknown rupture status who were between 24 and 42 weeks of gestation at Okmeydani Training and Research Hospital, Obstetrics and Gynecology outpatient clinics between September 2006 and May 2007. In patients with known rupture status, diagnosis was based on conventional methods, while the PAMG-1, IGFBP-1, and nitrazine tests were performed in patients with unknown rupture status. The patients were divided into three groups as Group 1 (n=30) without any signs of ROM, Group 2 (n=30) with typical signs of spontaneous ROM, and Group 3 (n=30) with symptoms suggestive of ROM who were unable to be diagnosed using conventional methods. Performance metrics of PAMG-1, IGFBP-1, and nitrazine tests were calculated and compared.
Results: Of the patients, the mean age was 28. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of nitrazine was 94.4%, 50.0%, 73.9%, and 85.7%, respectively. These values were 77.8%, 83.3%, 87.5%, and 71.4% for the IGFBP-1, respectively and 94.4%, 100%, 100%, and 92.3% for the PAMG-1, respectively. Accordingly, the PAMG-1 showed the highest diagnostic value in both the overall population and those with an equivocal status of ROM.
Conclusion: Our study results suggest that IGFBP-1 and nitrazine are not suitable for the diagnosis of unknown ROM and the PAMG-1 is a more accurate biomarker in patients with both known and unknown status of ROM. In addition, it is a simple and effective tool for the diagnosis of ROM in patients with unknown rupture status.

Proje Numarası

Okmeydanı Eğitim ve Araştırma Hastanesi -Uzmanlık Tezi 2007-1a

Kaynakça

  • 1. Dayal S, Hong PL; Premature rupture of membranes. StatPearls(internet).Treasure Island(FL): StatPearls Publishing:2018 Jan-2018 Dec 6.
  • 2. Sae-Lin P, Wanitpongpan P. İncidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital. J ObstetGynaecol Res. 2018 Dec 11.doi:10.1111/jog.13886
  • 3. Hanke K, Hartz A Manz M, Bendiks M etal. Preterm prelabor rupture of membranes and outcome of very-low-birthweight infants in the German Neonatal Network.PLoS One. 2015 Apr 9;10(4).
  • 4. Dera A, Breborowics GH, Keith L. Twin pregnancy - physiology, complications and the mode of delivery. Archives of Perinatal Medicine 2007;13(3):7-16.
  • 5. Mercer BM, Goldenberg RL, Meis PJ, et al. The Preterm Prediction Study: prediction of preterm premature rupture of membranes through clinical findings and ancillary testing. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J ObstetGynecol2000;183:738-45
  • 6. Vintzilleous AM, Wirston WA, Nochimson DJ et al. Degree of oligohydramnios and pregnancy outcome in patients with premature rupture of membranes. ObstetGynecol1985;66:162-7
  • 7. Trentacoste SV, Jean-Pierre C, Baergen R, Chasen ST. Outcomes of preterm premature rupture of membranes in twin pregnancies. J Matern Fetal Neonatal Med. 2008 Aug;21(8):555-7.
  • 8. Aris IM, Logan S, Lim C, Choolani M et al.Pretermprelabor rupture of membranes; a retrospective cohort studyof association with adverse outcome in subsequent pregnancy.BJOG. 2017 Oct;124(11):1698-1707
  • 9. Esteves JS, de SaRA, de Carvalho PR, Coca Velarde LG. Neonatal outcome in women with preterm premature rupture of membranes (PPROM) betwen 18and 26 weeks. Maternal Fetal Neonatal Med. 2016;29(7):1108-12
  • 10. Verspyck E, Bisson V, Roman H, Marret S (2014) Adverse respiratory outcome after premature rupture of membranes before viability. ActaPaediatr 103: 256–61.
  • 11. Williams O, Hutchings G, Hubinont C, Debauche C, Greenough A (2012) Pulmonary effects of prolonged oligohydramnios following mid-trimester rupture of the membranes—antenatal and postnatal management. Neonatology 101: 83–90.
  • 12. Gratacos E, Fıgureas F, Barranco M, et al. Spontaneous recovery of bacterial vaginosis during pregnancy is not associated with an improved perinatal outcome. ActaObstetGynecolScand1988;77:37-40
  • 13. Draper D, McGregor J, Hall J et al. Elevated protease activities in human amnion and chorion correlate with preterm premature rupture of membranes. Am J of ObstetGynecol1995;173:1506-12.
  • 14. Mercer BM, Goldenberg RL, Das A et al. The preterm prediction study: A clinical risk assessment system. Am J of ObstetGynecol1996;174:1885-95.
  • 15. Spinillo A, Capuzzo e, Piazzi G, et al. Risk for spontaneous preterm delivery by combined body mass index and gestational weight gain patterns. Am J ObstetGynecolScand1998;77:32-36.
  • 16. Kişnişçi, Gökşin, Durukan, Üstay, Ayhan, Gürgan, Önderoğlu. Temel Kadın HastalıklarıveDoğum Bilgisi.1481-1489, 1996.
  • 17. Waters TP, Mercer B. Preterm PROM: prediction, prevention, principles. ClinObstet Gynecol2011; 54: 307– 12.
  • 18. Parry S, Strauss JF. Premature rupture of fetal membranes. N Engl J Med 1998;338:663-70.
  • 19. McGregor JA, Johnson S. ’Fig-Leaf’ ferning and positive nitrazine testing: semen as a cause of misdiagnosis of premature rupture of membranes. Am J ObstetGynecol1985;151:1142-43
  • 20. de Han HH, Offermans PM, Smits F, Schouten HJ, Peeters LL. Value of the fern test to confirm or reject the diagnosis of ruptured membranes in modest in nonlaboring women presenting with nonspecific vaginal fluid loss. Am J Perinatol 1994; 11: 46-50
  • 21. Gaucherant P, Salle B, Sergeant P, et al. Comparative study of three vaginal markers of the premature rupture of membranes. Insulin lıke growth factor binding protein-1, daimine-oxidase, and pH.ActaObstetGynecol Scant 1997; 76: 536- 40
  • 22. Darj E, Lyrenas S. Insulin like growth factor binding-1, a quick way to detect amniotic fluid. ActaObstetGynecolScand 1998;77/3:295-7.
  • 23. Tatarinov YS, Kozljaeva GA, Petrunin DD, Petrunin YA. Two new human placenta-specıfıc α-globulins: Identification, purification, characteristics, cellular localization and clinical investigation. Serono Symposium No.35, ‘The Human Placenta’, edited by Kiopper A, Genazzani A, Crosignani PG. Academic Press, London and New York 1980;p:35-46.
  • 24. Ramsauer V, Duwe W, Schlehe B, Pitts R, Wagner D, Wutkewicz K, Chuvashkin D, Abele H, and Lachmann R. Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests. J. Perinat. Med. 2015 Jul;43(4):417-22.
  • 25. Abdelazim IA, Makhlouf HH. Placental alpha microglobulin-1 for detection of premature rupture of fetal membranes. Arch Gynecol Obstet. 2012 Apr;285(4):985-9
  • 26. Jeurgen-Borst AJ, Bekkers RL, Sporken JM, van den Berg PP. Use of insulin-like growth factor binding-1 in the diagnosis of ruptured fetal membranes. Eur J ObstetGynecolReprodBiol2002;10:102(1):11-4
  • 27. Lecerf M, Vardon D, Morello R, Lamendour N, Dreyfus M. Comparison of diagnostic performance of two tests of premature rupture of membranes (IGFP-1/PAMG-1) in clinical practice. J GynecolObstetBiolReprod (paris). 2015 Nov;44(9):832-9
  • 28. Igbinosa I, Moore III F.A,Johnson C, Block C.J. Comparison of rapid immunoassays for rupture of fetal membranes.BMCPregnanacy and Childbirth 2017;17:128
  • 29. Cousins LM, Smok DP, Lovett SM, Poeltler DM.AmniSure placental alpha microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes.Am J Perinatol2005 Aug;22(6):317-20.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kadın Hastalıkları ve Doğum
Bölüm Research Article
Yazarlar

Alparslan Deniz 0000-0003-1421-9962

Proje Numarası Okmeydanı Eğitim ve Araştırma Hastanesi -Uzmanlık Tezi 2007-1a
Yayımlanma Tarihi 31 Mart 2020
Gönderilme Tarihi 5 Ocak 2020
Kabul Tarihi 24 Şubat 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 17 Sayı: 1

Kaynak Göster

Vancouver Deniz A. Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes. JGON. 2020;17(1):262-5.