Yıl 2020, Cilt 17 , Sayı 1, Sayfalar 262 - 265 2020-03-31

Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes

Alparslan DENİZ [1]


Objective: This study aims to compare the placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test for the prediction of rupture of membranes (ROM) in women with known and unknown rupture status. Methods: This prospective study included a total of 90 patients with known and unknown rupture status who were between 24 and 42 weeks of gestation at Okmeydani Training and Research Hospital, Obstetrics and Gynecology outpatient clinics between September 2006 and May 2007. In patients with known rupture status, diagnosis was based on conventional methods, while the PAMG-1, IGFBP-1, and nitrazine tests were performed in patients with unknown rupture status. The patients were divided into three groups as Group 1 (n=30) without any signs of ROM, Group 2 (n=30) with typical signs of spontaneous ROM, and Group 3 (n=30) with symptoms suggestive of ROM who were unable to be diagnosed using conventional methods. Performance metrics of PAMG-1, IGFBP-1, and nitrazine tests were calculated and compared. Results: Of the patients, the mean age was 28. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of nitrazine was 94.4%, 50.0%, 73.9%, and 85.7%, respectively. These values were 77.8%, 83.3%, 87.5%, and 71.4% for the IGFBP-1, respectively and 94.4%, 100%, 100%, and 92.3% for the PAMG-1, respectively. Accordingly, the PAMG-1 showed the highest diagnostic value in both the overall population and those with an equivocal status of ROM. Conclusion: Our study results suggest that IGFBP-1 and nitrazine are not suitable for the diagnosis of unknown ROM and the PAMG-1 is a more accurate biomarker in patients with both known and unknown status of ROM. In addition, it is a simple and effective tool for the diagnosis of ROM in patients with unknown rupture status.
premature rupture of membranes, placental alpha microglobulin-1, insulin- like growth factor binding protein-1, nitrazine
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Birincil Dil en
Konular Kadın Hastalıkları ve Doğum
Bölüm Research Article
Yazarlar

Orcid: 0000-0003-1421-9962
Yazar: Alparslan DENİZ (Sorumlu Yazar)
Kurum: AlparslanDeniz, MD, Private Obstetrics and Gynecology Clinic, Manavgat, Antalya, TURKEY
Ülke: Turkey


Destekleyen Kurum yok
Proje Numarası Okmeydanı Eğitim ve Araştırma Hastanesi -Uzmanlık Tezi 2007-1a
Teşekkür Dear Editor, The manuscript entitled “Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes” has been submitted to the Jinekoloji-ObstetrikveNeonatolojiTıpDergisi. This study which was derived from the medical specialty thesis aims to compare the placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test for the prediction of rupture of membranes (ROM) in women with known and unknown rupture status. Although the study period is not recent, the most update literature data have been reviewed and the manuscript has been edited by a professional language editing service. Based on the study results, the PAMG-1 is a more accurate biomarker in patients with both known and unknown status of ROM than IGFBP-1 and nitrazine. Using this test rather than conventional methods may be helpful for early detection of ROM and positively affect the outcome of maternal and fetal health, as management of ROM can be performed in a timely manner, once the diagnosis is confirmed. The author herein certifies that he has no commercial, proprietary, or financial interest in the products or companies described in the manuscript. The author did not receive grants or a consultant honorarium to conduct the study, write the manuscript, or otherwise assist in the development of the aforementioned manuscript. The manuscript has been read and approved by the author. This manuscript has not been previously published or submitted for consideration to another journal or accepted for publication. In consideration of reviewing and editing submission, the author undersigned transfers, assigns and, otherwise, conveys all copyright ownership to theJinekoloji-ObstetrikveNeonatolojiTıpDergisi. Kindly submitted for your consideration for publication. Yours sincerely, Alparslan Deniz, MD Private Obstetrics and Gynecology Clinic, Manavgat, Antalya, TURKEY Tel: + 90 (242) 743 23 23 E-mail: dralparslandeniz@gmail.com
Tarihler

Başvuru Tarihi : 5 Ocak 2020
Kabul Tarihi : 24 Şubat 2020
Yayımlanma Tarihi : 31 Mart 2020

Bibtex @araştırma makalesi { jgon670609, journal = {Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi}, issn = {}, eissn = {2667-7849}, address = {Talatpaşa Bulvarı No 128, Hamamönü - ANKARA}, publisher = {T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi}, year = {2020}, volume = {17}, pages = {262 - 265}, doi = {}, title = {Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes}, key = {cite}, author = {DENİZ, Alparslan} }
APA DENİZ, A . (2020). Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi , 17 (1) , 262-265 . Retrieved from https://dergipark.org.tr/tr/pub/jgon/issue/53489/670609
MLA DENİZ, A . "Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes". Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 17 (2020 ): 262-265 <https://dergipark.org.tr/tr/pub/jgon/issue/53489/670609>
Chicago DENİZ, A . "Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes". Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 17 (2020 ): 262-265
RIS TY - JOUR T1 - Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes AU - Alparslan DENİZ Y1 - 2020 PY - 2020 N1 - DO - T2 - Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi JF - Journal JO - JOR SP - 262 EP - 265 VL - 17 IS - 1 SN - -2667-7849 M3 - UR - Y2 - 2020 ER -
EndNote %0 Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes %A Alparslan DENİZ %T Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes %D 2020 %J Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi %P -2667-7849 %V 17 %N 1 %R %U
ISNAD DENİZ, Alparslan . "Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes". Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 17 / 1 (Mart 2020): 262-265 .
AMA DENİZ A . Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes. JGON. 2020; 17(1): 262-265.
Vancouver DENİZ A . Comparison of PAMG-1 versus IGFBP-1 and Nitrazine in Diagnosis of Rupture of Membranes. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2020; 17(1): 265-262.