The relationship of erectile dysfunction severity with nocturnal blood pressure pattern and RDW

Yıl 2024, Cilt: 7 Sayı: 3, 332 - 336, 27.05.2024

Muzaffer Aslan Yunus Emre Yavuz Dogac Okşen Erdem Bal

https://doi.org/10.32322/jhsm.1476358

Öz

Aims: The study aimed to investigate the relationship between the severity of erectile dysfunction (ED), nocturnal blood pressure patterns, and red blood cell width distribution (RDW) in hypertensive patients.
Methods: The study involved 106 hypertensive patients, categorized into non-dippers and dippers based on their nocturnal blood pressure patterns. Key parameters including smoking status, RDW, and International Index of Erectile Function (IIEF) scores, were compared between the groups.
Results: The demographic data of the patients were similar. RDW was significantly higher in patients with non-dipper hypertension (HT) compared to the dipper group. Moderate and severe ED was seen more frequently in the non-dipper HT group (40.4% vs 20.4%; p=0.025). IIEF score was higher in the dipper HT group (17.6±6.9 vs 21.0±4.5; p=0.004). According to logistic regression analysis, age and smoking habit were significant predictors for moderate or severe ED.
Conclusion: The study highlights the significant association between non-dipping blood pressure patterns, elevated RDW, and the severity of ED in hypertensive patients. The findings underscore the importance of monitoring nocturnal blood pressure patterns and RDW in understanding and managing ED in this population.

Anahtar Kelimeler

Hypertension, Erythrocyte Indices, Erectile dysfunction

Etik Beyan

The study received ethical approval from the research committee of Siirt Training and Research Hospital on December 14, 2023, with reference number 94582.

Kaynakça

• Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction. J Urol. 1999;161(1):5-11.
• Kushiro T, Takahashi A, Saito F, et al. Erectile dysfunction and its influence on quality of life in patients with essential hypertension. Am J Hypertens. 2005;18(3):427-430.
• Kloner RA. Hypertension as a risk for erectile dysfunction: implications for sildenafil use. J Clin Hypertens. 2000;2(1):33-36.
• Schwarz ER, Rodriguez J. Sex and the heart. Int J Impot Res. 2005;17(1):S4-S6.
• Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med. 2007;120(2):151-157.
• Dursun M, Cimen S, Sulukaya M, Bugday MS, Besiroglu H. The predictive value of red cell distribution width on erectile dysfunction. Andrologia. 2019;51(10):e13374.
• Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21(3):177-181.
• Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet. 2007;370(9587):591-603.
• Altuntas M. Arteriyel hipertansiyon tanısında hasta eğitim düzeyi ve aile hekimliği uygulamasının rolü. Selcuk Med J. 2019; 35(1):31-36
• Ohkubo T, Hozawa A, Yamaguchi J, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens. 2002;20(11):2183-2189.
• Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension. 1994;24(6):793-801.
• Higashi Y, Nakagawa K, Kimura M, et al. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers. J Am Coll Cardiol. 2002;40(11):2039-2043.
• Marinakis AG, Vyssoulis GP, Michaelides AP, Karpanou EA, Cokkinos DV, Toutouzas PK. Impact of abnormal nocturnal blood pressure fall on vascular function. Am J Hypertens. 2003;16(3):209-213.
• Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822-830.
• Serefoglu EC, Atmaca AF, Dogan B, Altinova S, Akbulut Z, Balbay MD. Problems in understanding the Turkish translation of the international index of erectile function. J Androl. 2008;29(4):369-373.
• Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010;105(3):312-317.
• Uyarel H, Ergelen M, Cicek G, et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2011;22(3):138-144.
• Nagajothi N, Braverman A. Elevated red cell distribution width in the diagnosis of thrombotic thrombocytopenic purpura in patients presenting with anemia and thrombocytopenia. South Med J. 2007;100(3):257-259.
• Isik T, Uyarel H, Tanboga, et al. Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease. Coron Artery Dis. 2012;23(1):51-56.
• Erdogan A, Keskin E, Sambel M. Red blood cell distribution width values in erectile dysfunction. Rev Int Androl. 2022;20(1):24-30.
• Sohn MHH. Vascular Erectile Dysfunction. In: Lanzer P, Topol EJ, eds. Pan Vascular Medicine. Springer: 2002:1867-1874. doi: 10.1007/978-3-642-56225-9_133
• Küçük MF. The relationship between erectile dysfunction and macular and radial peripapillary microvascular densities in Behçet’s patients without ocular involvement. Selcuk Med J. 2022;38(1):8-16.
• Demir K, Kaya Z, Kayrak M, Bacaksız A, Duman Ç. Orta yaş hipertansif bireylerde kan basıncı kontrolü ve uyku kalitesi arasındaki ilişkinin analizi. Selçuk Üniv Tıp Derg. 2011;27(2):83-87.
• Costa C, Virag R. The endothelial-erectile dysfunction connection: an essential update. J Sex Med. 2009;6(9):2390-2404.
• Erden I, Ozhan H, Ordu S, Yalcin S, Caglar O, Kayikci A. The effect of non-dipper pattern of hypertension on erectile dysfunction. Blood Press. 2010;19(4):249-253.
• Yildirim V, Karakayali M, Uslu M, et al. Association between international index of erectile function-5 scores and circadian patterns of newly diagnosed hypertension in erectile dysfunction patients. Andrologia. 2022;54(1):e14383.
• Yuvanç E, Simsek V. The effect of nebivolol on erectile dysfunction with Dipper and non Dipper hypertensive patients. Am J Cardiol. 2018;122(4):679-685.
• Yuvanç E, Dogru MT, Simsek V, Kandemir H, Tuglu D. The effects of nocturnal blood pressure patterns and autonomic alterations on erectile functions in patients with hypertension. Urol J. 2019;16(2):198-204.
• Ateş İ, Mutlu D, Kaya S, Okutucu M, Sarıer M, Cilingiroglu M. Relationship between masked arterial hypertension and erectile dysfunction. J Mens Health. 2020;16(SP1):e4-e12.
• Kumaran T, Sujainath N, Rajeshkannan N, Nisahan B. Nocturnal systolic blood pressure pattern of type 2 diabetic hypertensive men with erectile dysfunction: a cross-sectional study from Northern Sri Lanka. BMC Res Notes. 2019;12(1):696.
• Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009;133(4):628-632.
• Teruhiko I. Detailed association between red blood cell distribution width and heart failure. Clin Cardiol. 2023;46(6):707.
• Drugescu A, Roca M, Zota IM, et al. Relationships between easily available biomarkers and non-Dipper blood pressure pattern in patients with stable coronary artery disease. Life (Basel). 2023;13(3):640.
• Latif SB, Das PK, Awal A, et al. Correlation between red cell distribution width and coronary artery disease in patients undergoing elective coronary angiography. Int J Res Med Sci. 2023;11(3):769-774.
• Buyukkaya E, Erayman A, Karakas, et al. Relation of red cell distribution width with dipper and non-dipper hypertension. Med Glasnik. 2016;13(2):75-81.