Effect The Cultural Applıcatıons on Cannabınoıds in Hemp (Cannabis sativa L.)

Öz

Hemp is one of the important annual plants belonging to the Cannabaceae family that has been the subject of humanity throughout history. In our country, hemp is an industrial plant known as kendir and çedene. Thanks to its fibers and chemical compounds, hemp is an important plant that is evaluated in terms of both health and textiles and has new generation usage areas in many fields. The secondary metabolites of hemp are generally called cannabinoids. Although there are more than 100 cannabinoids, 70 cannabinoids have been defined under 10 headings. The phytocannabinoids that are mostly focused on medically are THC (tetrahydrocannabinol), CBD (cannabidiol), CBDA (cannabidiolic acid), CBG (cannabigerol), and CBGA (cannabigerolic acid). These chemical compounds are highly influenced by genetic and environmental interactions. Especially, environmental factors have been reported to affect the synthesis of secondary products in the terpenophenolic structure of the plant in many studies. In this context, an evaluation has been made based on the literature on the effects of production techniques on the synthesis of phytocannabinoids in hemp.

Anahtar Kelimeler

• Hemp
• Cannabinoids
• Conventional applications
• Fitocannabinoid synthesis

Kenevirdeki ( Cannabis sativa L.) Kültürel Uygulamaların Kannabinoidlerin Üzerine Etkisi

Öz

Kenevir, tarih boyunca insanlığın üzerinde durmuş olduğu, Cannabaceae familyasına ait tek yıllık önemli bitkilerden biridir. Ülkemizde kenevir genellikle kendir ve çedene adı ile bilinen endüstriyel bir bitkidir. Kenevir lif ve içerdiği kimyasal bileşikler sayesinde hem sağlık hem de tekstil yönüyle değerlendirilen, pek çok alanda da yeni nesil kullanım alanları keşfedilen önemli bir bitkidir. Kenevirin ikincil metabolitleri genel anlamda kannabinoidler olarak isimlendirilmektedir. 100’ü aşkın kannabinoid olduğu bilinmekte birlikte, 70 kannabinoid 10 başlık altında tanımlanmıştır. Tıbbı anlamda en çok üzerinde durulan fitokannabinoidler; THC (tetrahidrokannabinol), CBD (Kannabidiol), CBDA (Kannabidiolik asit), CBG (Kannabigerol), CBGA (Kannabigerolik Asit) tir. Bu kimyasal bileşikler genetik ve çevre interaksiyonlarından oldukça etkilenmektedir. Özellikle çevresel faktörler bitkinin terpenofenolik yapıdaki ikincil ürünlerinin sentezini etkilediği pek çok çalışmanın sonucunda bildirilmiştir. Bu bağlamda, kenevirde üretim tekniklerinin kenevirdeki fitokannabinoid sentezi üzerindeki etkileri noktasında literatür ışığında bir değerlendirme yapılmıştır

Anahtar Kelimeler

• Kenevir
• Kannabinoidler
• Kültürel uygulamalar
• Fitokannabinoid sentezi

Kaynakça

1. Anonim. (2018). CBD kenevir çeşitleri - en iyi TOP URL:https://tr.cannadorra.com/en/articles/hemp-articles-and-information/cbd-hemp-varieties-best-top-10 (erişim tarihi: 25 Nisan, 2023).
2. Anderson, S. L., Pearson, B., Kjelgren, R., & Brym, Z. (2021). Response of essential oil hemp (Cannabis sativa L.) growth, biomass, and cannabinoid profiles to varying fertigation rates. PLoS One, 16(7), e0252985. Retrieved from https://doi.org/10.1371/journal.pone.0252985.
3. Atakan, Z. (2012). Cannabis, a complex plant: different compounds and different effects on individuals, The Advanced Psychopharmacol. 2(6): 241–254. Retrieved from https://doi.org/10.1177/2045125312457586.
4. Aytaç, S., Arslanoğlu, Ş. F. ve Ayan, A. K. (2018). Suçlu olarak bilinen bitki: kenevir. Current Academic Studies in Agricultural Sciences, 550. Retrieved from
5. Aytaç , S., Kenevir; Çiftçi Eğitimleri Söyleşi. Samsun Vezirköprü, (2022).
6. Backer, R. G., Rosenbaum, P., Mccarty, V., Eıchhorn Bılodeau, S., Lyu, D., Ahmed, M. B. ve Smıth, D. L. (2019). Closing the yield gap for cannabis: a meta-analysis of factors determining cannabis yield. Frontiers in Plant Science, 10, 495. Retrieved from https://doi.org/10.3389/fpls.2019.00495.
7. Başbağ., S.ve Ekinci, R. (2020). Bölüm 5. S. Başbağ. ve R. Ekinci içinde, kenevir tarımı (s. 61-84). researchgate. Balpınar Ö., Aytaç S. Tıbbi kenevir ve sağlık: farmakolojik bir derleme. Ankara Eczacılık Fakültesi Dergisi 2021; 45(3): 631-651. Retrieved from https://doi.org/10.33483/jfpau.859372.
8. Bernstein, N., Gorelick, J., Zerahia, R.ve Koch, S. (2019). Impact of N, P, K, and humic acid supplementation on the chemical profile of medical cannabis (Cannabis sativa L). Frontiers in plant science, 10, 736. Retrieved from https://doi.org/10.3389/fpls.2019.00736.

9. Beşir, A., Bektaş, N. Y., M. M.ve Yazıcı, F. (2022). Kenevirde THC ve CBD Faktörlerinin Değerlendirilmesi. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 1092-1104,. Retrieved from https://doi.org/10.47495/okufbed.1089331.
10. Burgel, L., Hartung, J., Schibano, D. ve Graeff-Hönninger, S. (2020). Impact of different phytohormones on morphology, yield and cannabinoid content of Cannabis sativa L. Plants, 9(6), 725. Retrieved from https://doi.org/10.3390/plants9060725.
11. Caffarel, M. M., Andradas, C., Mira, E., Pérez-Gómez, E., Cerutti, C., Moreno-Bueno, G., ... & Sánchez, C. (2010). Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Molecular cancer, 9(1), 1-11. Retrieved from https://doi.org/10.1186/1476-4598-9-196.
12. Caplan, D., Dıxon, M. ve Youbın, Z. (2017). Optimal rate of organic fertilizer during the vegetative-stage for cannabis grown in two coir-based substrates. HortScience, 52, 1307-1312. Retrieved from https://doi.org/10.21273/HORTSCI11903-17.
13. Chandra, S., Lata, H., Khan, I. A. ve Elsohly, M. A.(2011). Photosynthetic response of Cannabis sativa L., an important medicinal plant, to elevated levels of CO2. Physiology and Molecular Biology of Plants, 17(3), 291-295. Retrieved from https://doi.org/10.1007/s12298-011-0066-6.
14. Chandra, S., Lata, H., Khan, I. A. ve Elsohly, M. A. (2008). Photosynthetic Response of Cannabis sativa L. to Variations in Photosynthetic Photon Flux Densities, Temperature and CO2Conditions. Physiology and Molecular Biology of Plants, 14, 299-306. Retrieved from https://doi.org/10.1007/s12298-008-0027-x.
15. Chen, J., & Poon, C. S. (2009). Photocatalytic construction and building materials: from fundamentals to applications. Building and environment, 44(9), 1899-1906. Retrieved from https://doi.org/10.1016/j.buildenv.2009.01.002.
16. Chung, S. C., Hammarsten, P., Josefsson, A., Stattin, P., Granfors, T., Egevad, L., ... & Fowler, C. J. (2009). A high cannabinoid CB1 receptor immunoreactivity is associated with disease severity and outcome in prostate cancer. European Journal of Cancer, 45(1), 174-182. Retrieved from https://doi.org/10.1016/j.ejca.2008.10.010.
17. Conant, R., Walsh, R., Walsh, M., Bell, C. ve Wallensteın, M. (2017). Effects of a Microbial Biostimulant, Mammoth PTM, on Cannabis sativa Bud Yield. J. Hortic. Forestry, 4, 2376–0354. Retrieved from 10.4172/2376-0354.1000191.
18. Crispim Massuela, D., Hartung, J., Munz, S., Erpenbach, F.ve Graeff-Hönninger, S. (2022). Impact of harvest time and pruning technique on total cbd concentration and yield of medicinal cannabis. Plants, 11(1), 140. Retrieved from https://doi.org/10.3390/plants11010140.
19. Das, P. C., Vista, A. R., Tabil, L. G., & Baik, O. D. (2022). Postharvest operations of cannabis and their effect on cannabinoid content: A review. Bioengineering, 9(8), 364. Retrieved from https://doi.org/10.3390/bioengineering9080364.
20. De Prato, L., Ansari, O., Hardy, G. E. S. J., Howieson, J., O’Hara, G.ve Ruthrof, K. X. (2022). Morpho-physiology and cannabinoid concentrations of hemp (Cannabis sativa L.) are affected by potassium fertilisers and microbes under tropical conditions. Industrial Crops and Products, 182, 114907. Retrieved from https://doi.org/10.1016/j.indcrop.2022.114907.
21. De Prato, L., Ansari, O., Hardy, G. E. S. J., Howieson, J., O'Hara, G., & Ruthrof, K. X. (2022a). The cannabinoid profile and growth of hemp (Cannabis sativa L.) is influenced by tropical daylengths and temperatures, genotype and nitrogen nutrition. Industrial Crops and Products, 178, 114605. Retrieved from https://doi.org/10.1016/j.indcrop.2022.114605.
22. Göre, M.ve Kurt, O. (2020). Bitkisel Üretimde Yeni Bir Trend: Kenevir. Research article, 138-157. Retrieved from https://doi.org/10.38001/ijlsb.789970.
23. Gökgöz, A.ve Can, E. Y. (2021). Medikal ve Endüstriyel Açıdan Kannabinoidlerin Önemi ve Türkiye Ekonomisine Katkı Potansiyeli. Batı Karadeniz Tıp Dergisi, 5(3), 315-323. Retrieved from https://doi.org/10.29058/mjwbs.928899.
24. Glivar, T., Eržen, J., Kreft, S., Zagožen, M., Čerenak, A., Čeh, B., & Benković, E. T. (2020). Cannabinoid content in industrial hemp (Cannabis sativa L.) varieties grown in Slovenia. Industrial crops and products, 145, 112082. Leggett, T. (2006). A review of the world cannabis situation. Bull Narc, 58(1-2), 1-155. Retrieved from https://doi.org/10.1016/j.indcrop.2019.112082.
25. KOCA ÇALIŞKAN, U. F. U. K. (2020). Hemp And Its Use In Health (Kenevir Ve Sağlık Alanında Kullanımı). J. Fac. Pharm. Ankara/Ankara Ecz. Fak. Derg., 44(1). Retrieved from https://doi.org/10.33483/jfpau.559665.
26. Lewıs, G. S. ve Turner, C. E. (1978). Constituents of Cannabis sativa L. XIII: stability of dosage form prepared by impregnating synthetic (-)D9 -trans-tetrahydrocannabinol on placebo Cannabis plant material. J Pharm Sci, 67, 876-878. Retrieved from https://doi.org/10.1002/jps.2600670645.
27. Lowe, H., Steele, B., Bryant, J., Toyang, N.ve Ngwa, W. (2021). Non-cannabinoid metabolites of Cannabis sativa L. with therapeutic potential. Plants, 10(2), 400. Retrieved from https://doi.org/10.3390/plants10020400.
28. Mansourı, H., Asrar, Z. ve Szopa, J. (2009). Effects of ABA on primary terpenoids and 19-tetrahydrocannabinol in Cannabis sativa L. at flowering stage. Plant GrowthRegul. 58, 269-277. Retrieved from https://doi.org/10.1007/s10725-009-9375-y.
29. Mansouri, H., Asrar, Z.ve Amarowicz, R. (2011). The response of terpenoids to exogenous gibberellic acid in Cannabis sativa L. at vegetative stage. Acta Physiologiae Plantarum, 33, 1085-1091.. in vegetative stage. Journal of Essential Oil Bearing Plants, 19(1), 94– 102. Retrieved from https://doi.org/10.1080/0972060X.2015.1004122.
30. Mishchenko, S. V., Laiko, I. M., Tkachenko, S. M., Lavrynenko, Y. O., Marchenko, T. Y., & Piliarska, O. O. (2022). The influence of exogenous growth regulators on the cannabinoid content and the main selection traits of hemp (Cannabis sativa L. ssp. Sativa). Journal of Agricultural Sciences (Belgrade), 67(3), 237-251. Retrieved from https://doi.org/10.2298/JAS2203237M.
31. Morello, V., Brousseau, V. D., Wu, N., Wu, B. S., MacPherson, S.ve Lefsrud, M. (2022). Light Quality Impacts Vertical Growth Rate, Phytochemical Yield and Cannabinoid Production Efficiency in Cannabis sativa. Plants, 11(21), 2982. Retrieved from https://doi.org/10.3390/plants11212982.
32. Potter, D. J. (2014). A review of the cultivation and processing of cannabis (Cannabis sativa L.) for production of prescription medicines in the UK. Drug Testing and Analysis, 6(1-2), 31-38. Retrieved from https://doi.org/10.1002/dta.1531.
33. Razdan, R. K., Puttıck, A. J., Zıtko, B. A. ve Handrıck, G. R. (1972). Hashish VI: conversion of -)-D16)-tetrahydrocannabinol to -)-D17)- tetrahydrocannabinol, stability of -)-D1 - and -)-D16)- tetrahydrocannabinols. Experientia, 28, 121-122. Retrieved from https://doi.org/10.1007/BF01935704.
34. Salami SA., Martinelli F., Giovino A., Bachari A., Arad N., Mantri N. (2020). It ıs our turn to get cannabis high: Put cannabinoids in food and health baskets. Molecules . 25(18): 4036. Retrieved from https://doi.org/10.3390/molecules25184036.
35. Saloner, A.ve Bernstein, N. (2021). Nitrogen supply affects cannabinoid and terpenoid profile in medical cannabis (Cannabis sativa L.). Industrial Crops and Products, 167, 113516. Retrieved from https://doi.org/10.1016/j.indcrop.2021.113516.
36. Sikora, V., Berenji, J., & Latković, D. (2011). Influence of agroclimatic conditions on content of main cannabinoids in industrial hemp (Cannabis sativa L.). Genetika-Belgrade, 43(3), 449-456. Retrieved from http://dx.doi.org/10.2298/GENSR1103449S.
37. Schley, M., Ständer, S., Kerner, J., Vajkoczy, P., Schüpfer, G., Dusch, M., ... & Konrad, C. (2009). Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans. Brain research bulletin, 79(5), 333-337. Retrieved from https://doi.org/10.1016/j.brainresbull.2009.01.011.
38. Vanhove, W., P. V.ve N. M. (2011). Factors determining yield and quality of illicit indoor cannabis (Cannabis spp.) production. Forensic Science International 212, 158-163. Retrieved from https://doi.org/10.1016/j.forsciint.2011.06.006.
39. Wei, X., Zhou, W., Long, S., Guo, Y., Qiu, C., Zhao, X., & Wang, Y. (2023). Effects of Different N, P, and K Rates on the Growth and Cannabinoid Content of Industrial Hemp. Journal of Natural Fibers, 20(1), 2159605. Retrieved from https://doi.org/10.1080/15440478.2022.2159605.