Araştırma Makalesi

Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity

Cilt: 14 Sayı: 2 1 Haziran 2024
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Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity

Öz

In Kars-Sarıkamış-Soğanlı, Angelica purpurascens (A. purpurascens) emerges as a promising natural antioxidant source. Extracts from its leaves, branches, and flowers underwent thorough bioanalytical assessments. The leaf extract exhibited the highest concentrations of herbal flavonoids (45.22 µg QE/mg extract) and total phenolics (28.96 µg GAE/mg extract). Branch extracts demonstrated significant enzymatic activity against AChE and BChE with IC50 values of 37.26 mg/mL and 9.08 mg/mL respectively. The flower extract displayed notable antibacterial properties. This study sheds light on the therapeutic potential of A. purpurascens ethanol extracts, suggesting benefits for Alzheimer’s, cell damage-induced diseases, and diabetes mellitus. It pioneers new enzymatic and antioxidant insights and contributes to understanding this abundant Türkiye species. A. purpurascens holds promise for pharmaceutical exploration, offering potential solutions for challenging health conditions

Anahtar Kelimeler

Destekleyen Kurum

This study has been supported by Gümüşhane University Scientific Research Projects Coordination Department (Project No: 22.B0225.02.01).

Proje Numarası

22.B0225.02.01

Teşekkür

This study has been supported by Gümüşhane University Scientific Research Projects Coordination Department (Project No: 22.B0225.02.01).

Kaynakça

  1. Aćimović, M. G., Pavlović, S. Đ., Varga, A. O., Filipović, V. M., Cvetković, M. T., Stanković, J. M., & Čabarkapa, a. I. S. (2017). Chemical Composition and Antibacterial Activity of Angelica archangelica Root Essential Oil. Natural Product Communications, 12(2), 205-206.
  2. Apak, R., Güçlü, K., Özyürek, M., Esin Karademir, S., & Erçağ, E. (2006). The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. International Journal of Food Sciences and Nutrition, 57(5-6), 292-304.
  3. Ashleigh, T., Swerdlow, R. H., & Beal, M. F. (2023). The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis. Alzheimer's & Dementia, 19(1), 333-342.
  4. Bhatia, V., & Sharma, S. (2021). Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease. Journal of the Neurological Sciences, 421, 117253.
  5. Bingöl, Z., Kızıltaş, H., Gören, A. C., Kose, L. P., Topal, M., Durmaz, L., . . . Gulcin, I. (2021). Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.)-profiling of phenolic compounds by LC-HRMS. Heliyon, 7(5), e06986.
  6. Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199-1200.
  7. Bursal, E., Aras, A., Kılıç, Ö., Taslimi, P., Gören, A. C., & Gülçin, İ. (2019). Phytochemical content, antioxidant activity, and enzyme inhibition effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α‐amylase, butyrylcholinesterase, and α‐glycosidase enzymes. Journal of Food Biochemistry, 43(3), e12776.
  8. Chunchao Han, C., & Guo, J. (2012). Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens. Inflammation, 35(3).

Ayrıntılar

Birincil Dil

İngilizce

Konular

Tıbbi ve Biyomoleküler Kimya (Diğer)

Bölüm

Araştırma Makalesi

Erken Görünüm Tarihi

28 Mayıs 2024

Yayımlanma Tarihi

1 Haziran 2024

Gönderilme Tarihi

28 Aralık 2023

Kabul Tarihi

19 Mart 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 14 Sayı: 2

Kaynak Göster

APA
Topal, M., Topal, F., & Yılmaz, F. (2024). Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity. Journal of the Institute of Science and Technology, 14(2), 790-804. https://doi.org/10.21597/jist.1411501
AMA
1.Topal M, Topal F, Yılmaz F. Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity. Iğdır Üniv. Fen Bil Enst. Der. 2024;14(2):790-804. doi:10.21597/jist.1411501
Chicago
Topal, Meryem, Fevzi Topal, ve Fırat Yılmaz. 2024. “Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity”. Journal of the Institute of Science and Technology 14 (2): 790-804. https://doi.org/10.21597/jist.1411501.
EndNote
Topal M, Topal F, Yılmaz F (01 Haziran 2024) Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity. Journal of the Institute of Science and Technology 14 2 790–804.
IEEE
[1]M. Topal, F. Topal, ve F. Yılmaz, “Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity”, Iğdır Üniv. Fen Bil Enst. Der., c. 14, sy 2, ss. 790–804, Haz. 2024, doi: 10.21597/jist.1411501.
ISNAD
Topal, Meryem - Topal, Fevzi - Yılmaz, Fırat. “Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity”. Journal of the Institute of Science and Technology 14/2 (01 Haziran 2024): 790-804. https://doi.org/10.21597/jist.1411501.
JAMA
1.Topal M, Topal F, Yılmaz F. Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity. Iğdır Üniv. Fen Bil Enst. Der. 2024;14:790–804.
MLA
Topal, Meryem, vd. “Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity”. Journal of the Institute of Science and Technology, c. 14, sy 2, Haziran 2024, ss. 790-04, doi:10.21597/jist.1411501.
Vancouver
1.Meryem Topal, Fevzi Topal, Fırat Yılmaz. Exploring the Impacts of Angelica purpurascens Extracts on Anticholinergic, Antidiabetic, Antibacterial Potential, and Antioxidant Capacity. Iğdır Üniv. Fen Bil Enst. Der. 01 Haziran 2024;14(2):790-804. doi:10.21597/jist.1411501