Encapsulation Applications and Current Studies in Food Technology

Öz

Encapsulation, as a method that provides controlled release and stability of food components, cells, enzymes and different substances in protein or carbohydrate-based mini capsules. In other words, it can also be defined as keeping the active material to be used in nano, micro or millimeter sized coating materials. The encapsulation method has great importance and potential for the food industry. In this method, it is aimed to mask undesirable taste and aroma components, to protect the bioactive compounds used from external factors, to increase the utilization of their functionality, and to control their release during shelf life. Various components such as some valuable food components, essential oils, lipids, aromatic hydrocarbons, vitamins, flavourings, enzymes, colourants, microorganisms, and microbial metabolites can be encapsulated using different methods. In this review, the encapsulation process types, coating materials, application areas in food technology and current studies in the field were investigated in order to understand the method. In the review, general information is given for encapsulation technology and a brief literature summary is intended for new studies to be conducted.

Anahtar Kelimeler

• Food
• Encapsulation
• Controlled release

Gıda Teknolojisinde Enkapsülasyon Uygulamaları ve Güncel Çalışmalar

Öz

Enkapsülasyon gıda bileşen, hücre, enzim ve farklı maddelerin, protein veya karbonhidrat bazlı mini kapsüller içinde tutulup kontrollü salınımı ve stabilitesini sağlayan bir yöntemdir. Bir başka deyişle kullanılacak aktif materyalin nano, mikro veya milimetrik ölçülerde kaplama malzemeleri içinde tutulması olarak da tanımlanabilir. Enkapsülasyon metodunun gıda endüstrisi için büyük bir potansiyeli vardır. Bu yöntemde istenmeyen tat ve aroma bileşenlerinin maskelenmesi, kullanılan biyoaktif bileşiklerin dış etkenlerden korunması, bu bileşenlerin fonksiyonelliğinden yararlanımın arttırılması ve raf ömrü boyunca kontrollü salınımı hedeflenir. Değerli bazı gıda bileşenleri, esansiyel yağlar, lipitler, aromatik hidrokarbonlar, vitaminler, tatlandırıcılar, enzimler, renklendiriciler, mikroorganizmalar ve mikrobiyal metabolitler gibi çeşitli bileşenler farklı yöntemler kullanılarak enkapsüle edilebilmektedir. Bu derlemede, yöntemi anlamak için gerekli olan enkapsülasyon prosesleri, kaplama materyalleri, gıda teknolojisindeki uygulama alanları ve alanda yapılmış güncel çalışmalar araştırılmıştır. Derlemede, enkapsülasyon teknolojisi için genel bilgiler verilmekte olup yapılacak yeni çalışmalar için kısa bir literatür özeti olması hedeflenmiştir.

Anahtar Kelimeler

• Gıda
• Enkapsülasyon
• Kontrollü salınım

Kaynakça

1. Açu, M., Yerlikay, O., & Kınık, Ö. (2014). Mikroenkapsülayon ve Süt Teknolojisindeki Yeri. Akademik Gıda, 12, 97-107.
2. Aditya, N. P., Espinosa, Y. G., & Norton, I. T. (2017). Encapsulation systems for the delivery of hydrophilic nutraceuticals: Food application. Biotechnology advances, 35(4), 450-457.
3. Ahmadi, H. (2017). Thermal Stability of Encapsulated Listeria Bacteriophage and its Efficacy against Listeria Monocytogenes in Ready-to-Eat Meats. Doctoral Dissertation, the University of Guelph, Canada.
4. Altamirano‐Ríos, A. V., Guadarrama‐Lezama, A. Y., Arroyo‐Maya, I. J., Hernández‐Álvarez, A. J., & Orozco‐Villafuerte, J. (2022). Effect of encapsulation methods and materials on the survival and viability of Lactobacillus acidophilus: A review. International Journal of Food Science & Technology, 57(7), 4027-4040.
5. Alves, D., Marques, A., Milho, C., Costa, M. J., Pastrana, L. M., Cerqueira, M. A., & Sillankorva, S. M. (2019). Bacteriophage Φıbb-Pf7a Loaded on Sodium Alginate-Based Films to Prevent Microbial Meat Spoilage. International Journal of Food Microbiology, 291, 121-127.
6. Alvim, I. D., Stein, M. A., Koury, I. P., Dantas, F. B. H., & Cruz, C. (2016). Comparison between the Spray Drying and Spray Chilling Microparticles Contain Ascorbic Acid in a Baked Product Application. Lwt-Food Science and Technology, 65, 689-694.
7. Anandharamakrishnan, C.,& Parthasarathi, S. (Eds.). (2019). Food nanotechnology: principles and applications. CRC Press.
8. Araújo, C. M., Sampaio, K. B., Menezes, F. N. D. D., Almeida, E. T. D. C., Lima, M. D. S., Viera, V. B., & de Oliveira, M. E. G. (2020). Protective effects of tropical fruit processing coproducts on probiotic Lactobacillus strains during freeze-drying and storage. Microorganisms, 8(1), 96.

9. Aslan, K. Ş. (2021). Ruşeym Yağının Tereyağı Yayıkaltı Suyu Bileşenleri ile Enkapsülasyonu. Yüksek Lisans Tezi, İnönü Üniversitesi Fen Bilimleri Enstitüsü, Malatya.
10. Atak, Z., Koç, M., & Kaymak-Ertekin, F. (2017). Gıda Endüstrisinde Aroma Mikroenkapsülasyonu. Akademik Gıda, 15(4), 416-425.
11. Azab, D. E., Heikal, Y. A., Salaheldin, T. A., Hassan, A. A., & Abu-Salem, F. M. (2019). Nano formulated soy proteins for improvement of beef burgers quality. Egyptian Journal of Chemistry, 62(7), 1167-1184.
12. Azagheswari, B. K., Padma, S., & Priya, S. P. (2015). A review on microcapsules. Global Journal of Pharmacology, 9(1), 28-39.
13. Barbosa, M. S., Todorov, S. D., Jurkiewicz, C. H., & Franco, B. D. (2015). Bacteriocin production by Lactobacillus curvatus MBSa2 entrapped in calcium alginate during ripening of salami for control of Listeria monocytogenes. Food control, 47, 147-153.
14. Burgain, J., Gaiani, C., Linder, M., & Scher, J. (2011). Encapsulation of probiotic living cells: From laboratory scale to industrial applications. Journal of food engineering, 104(4), 467-483.
15. Cavalheiro, C. P., Menezes, C. R., Fries, L. L. M., Ruiz-Capillas, C., Herrero, A. M., & Jimeenez-Colmenero, F. (2015). Alginate Beads to İmprove Viability of Lactobacillus Plantarum to Heat Stress. Journal of Food Processing and Technology, 6: 126.
16. Chatain, M.H.L. (2014). The Factors Affecting Effectiveness of Treatment in Phages Therapy. Frontiers in Microbiology 5(51): 1-6.
17. Coghetto, C. C., Brinques, G. B., & Ayub, M. A. Z. (2016). Probiotics production and alternative encapsulation methodologies to improve their viabilities under adverse environmental conditions. International journal of food sciences and nutrition, 67(8), 929-943.
18. Cui, H., Yuan, L., Ma, C., Li, C., & Lin, L. (2017). Effect of Nianoliposome‐Encapsulated Thyme Oil on Growth of Salmonella Enteritidis in Chicken. Journal of Food Processing and Preservation, 41: 13299.
19. da Silva, M. N., Tagliapietra, B. L., & dos Santos Richards, N. S. P. (2021). Encapsulation, storage viability and consumer acceptance of probiotic butter. Lwt-Food Science and Technology, 139, 110536.
20. da Silva, T. M., Lopes, E. J., Codevilla, C. F., Cichoski, A. J., de Moraes Flores, É. M., Motta, M. H., & de Menezes, C. R. (2018). Development and characterization of microcapsules containing Bifidobacterium Bb-12 produced by complex coacervation followed by freeze drying, Lwt-Food Science and Technology, 90, 412-417.
21. Desai, K. G. H., & Jin Park, H. (2005). Recent Developments in Microencapsulation of Food İngredients. Drying Technology, 23(7), 1361-1394.
22. Dima, C., Cotârlet, M., Alexe, P., & Dima, S. (2014). Microencapsulation of Essential Oil of Pimento [Pimenta Dioica (L) Merr.] by Chitosan/K-Carrageenan Complex Coacervation Method. Innovative Food Science & Emerging Technologies, 22, 203-211.
23. Drusch, S. (2007). Sugar Beet Pectin: A Novel Emulsifying Wall Component for Microencapsulation of Lipophilic Food İngredients by Spray-Drying. Food Hydrocolloids, 21(7), 1223-1228.
24. Dubey, R., Shami, Tc., & Rao, Bku. (2009) Microencapsulation Technology and Applications. Journal of Defence Science, 59(1): 82-95.
25. Duman, F., & Kaya, M. (2016). Crayfish Chitosan for Microencapsulation of Coriander (Coriandrum Sativum L.) Essential Oil. International Journal of Biological Macromolecules, 92, 125-133.
26. El Sayed, H. S., & Mabrouk, A. M. (2023). Encapsulation of probiotics using mixed sodium alginate and rice flour to enhance their survivability in simulated gastric conditions and in UF-Kariesh cheese. Biocatalysis and Agricultural Biotechnology, 50, 102738.
27. Eratte, D., Dowling, K., Barrow, C. J., & Adhikari, B. (2018). Recent advances in the microencapsulation of omega-3 oil and probiotic bacteria through complex coacervation: A review. Trends in food science & technology, 71, 121-131.
28. Erdem, F., Gündoğan, E.N., Yılmaz, M.S., Sezgin, İ., Summakoğlu, Y., & Şakıyan, Ö. (2021). Microencapsulation of Rosehip (Rosa Canina) Phenolic Compounds. Gıda, 46 (4) 1026-1039.
29. Fang, Z., & Bhandari, B. (2010). Encapsulation of Polyphenols–A Review. Trends in Food Science & Technology, 21(10), 510-523.
30. Frakolaki, G., Giannou, V., Kekos, D., & Tzia, C. (2021). A Review of the Microencapsulation Techniques for the İncorporation of Probiotic Bacteria in Functional Foods. Critical Reviews in Food Science and Nutrition, 61(9), 1515-1536.
31. Geankoplis CJ, Hersel AA, Lepek DH (2018) Transport processes and separation process principles. Prentice Hall, Boston, MA.
32. Geniş, B., & Tuncer, Y. (2019). Probiyotik kültürlerin mikroenkapsülasyonunda kullanılan farklı kaplama materyalleri ve yöntemler. Gıda, 44(6), 1222-1236.
33. Ghorbanzade, T., Jafari, S. M., Akhavan, S., & Hadavi, R. (2017). Nano-encapsulation of fish oil in nano-liposomes and its application in fortification of yogurt. Food chemistry, 216, 146-152.
34. Gökmen, S., Palamutoğlu, R., & Sarıçoban, C. (2012). Applications of Encapsulation in Food Industry. Electronic Journal of Food Technologies, 7: 36-50.
35. Hadian, M., Rajaei, A., Mohsenifar, A., & Tabatabaei, M. (2017). Encapsulation of Rosmarinus Officinalis Essential Oils in Chitosan-Benzoic Acid Nanogel with Enhanced Antibacterial Activity in Beef Cutlet Against Salmonella Ttyphimurium during Refrigerated Storage. Lwt-Food Science and Technology, 84: 394-401.
36. Heidebach, T., Först, P., & Kulozik, U. (2012). Microencapsulation of probiotic cells for food applications. Critical Reviews in Food Science and Nutrition, 52(4), 291-311.
37. Heinzelmann, K., Franke, K., Jensen, B., & Haahr, A. (2000). Protection of Fish Oil from Oxidation by Microencapsulation Using Freeze-Drying Techniques. European Journal of Lipid Science and Technology, 102 (2): 114–121.
38. Huq, T., Khan, A., Khan, R. A., Riedl, B., & Lacroix, M. (2013). Encapsulation of probiotic bacteria in biopolymeric system. Critical Reviews in Food Science and Nutrition, 53(9), 909-916.
39. Ibrahim, S. M., Abed, K. A., Gad, M. S., & Hashish, H. A. (2020). Comparison of different methods for producing bio oil from Egyptian jatropha seeds. Biofuels, 11(6),643-654.
40. Kanat, S., & Gülel, G. T. (2021). Mikroenkapsülasyon ve Gıda Endüstrisinde Kullanım Alanları. Aydın Gastronomy, 5(1), 81-89.
41. Koç, M., Sakin, M., & Ertekin, F. K. (2010). Mikroenkapsülasyon ve Gıda Teknolojisinde Kullanımı. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 16(1), 77-86.
42. Kowsalya, M., Sudha, K. G., Ali, S., Velmurugan, T., & Rajeshkumar, M. P. (2023). Sustainability and Controlled Release Behavior of Microencapsulated Lactobacillus Plantarum Prk7 and its Application in Probiotic Yogurt Production. Food Bioscience, 102430.
43. Lopes, L. A. A., Pimentel, T. C., Carvalho, R. D. S. F., Madruga, M. S., De Sousa Galvão, M., Bezerra, T. K. A., & Stamford, T. C. M. (2021). Spreadable Goat Ricotta Cheese Added with Lactobacillus Acidophilus La-05: Can Microencapsulation İmprove the Probiotic Survival and The Quality Parameters?, Food Chemistry, 346, 128769.
44. Marković, J. M., Salević-Jelić, A. S., Milinčić, D. D., Gašić, U. M., Pavlović, V. B., Rabrenović, B. B., & Mihajlović, D. M. (2024). Encapsulated horseradish (Armoracia rusticana L.) root juice: Physicochemical characterization and the effects of its addition on the oxidative stability and quality of mayonnaise. Journal of Food Engineering, 112189.
45. Martin, M. J., Lara-Villoslada, F., Ruiz, M. A., & Morales, M. E. (2015). Microencapsulation of Bacteria: A Review of Different Technologies and their İmpact on the Probiotic Effects. Innovative Food Science and Emerging Technologies, 27, 15-25
46. McClements, D. J. (2015). Encapsulation, protection, and release of hydrophilic active components: Potential and limitations of colloidal delivery systems. Advances in colloid and interface science, 219, 27-53.
47. Nakilcioğlu-Taş, E., & Ötleş, S. (2021). Zeytin Çekirdeği Antioksidanlarının Dondurarak Kurutma Tekniği ile Mikroenkapsülasyonu: Toz Ürünün Fiziksel ve Kimyasal Karakterizasyonu. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi, 10(1), 140-149.
48. Nami, Y., Lornezhad, G., Kiani, A., Abdullah, N., & Haghshenas, B. (2020). Alginate-Persian Gum-Prebiotics microencapsulation impacts on the survival rate of Lactococcus lactis ABRIINW-N19 in orange juice. Lwt-Food Science and Technology, 124, 109190.
49. Nazzaro, F., Orlando, P., Fratianni, F., & Coppola, R. (2012). Microencapsulation in Food Science and Biotechnology. Current Opinion in Biotechnology, 23, 182-186.
50. Nedovic, V., Kalusevic, A., Manojlovic, V., Levic, S., & Bugarski, B. (2011). An Overview of Encapsulation Technologies for Food Applications. Procedia Food Science, 1: 1806-1815.
51. Oliveira, F. M., Oliveira, R. M., Buchweitz, L. T. G., Pereira, J. R., dos Santos Hackbart, H. C., Nalério, É. S., & Zambiazi, R. C. (2022). Encapsulation of olive leaf extract (Olea europaea L.) in gelatin/tragacanth gum by complex coacervation for application in sheep meat hamburger. Food Control, 131, 108426.
52. Özcan, T., & Altun, B. (2013). Süt ürünlerinde probiyotik bakterilerin mikroenkapsülasyonu I: enkapsülasyon teknikleri. Uludağ Üniversitesi Ziraat Fakültesi Dergisi, 27(2), 93-104.
53. Özkan, N. (2021). Vanilinin Farklı Kaplama Materyalleri Kullanılarak Dondurarak Kurutma Yöntemi ile Mikroenkapsülasyonu ve Bisküvi Üretiminde Kullanımı. Yüksek Lisans Tezi, Necmettin Erbakan Üniversitesi Fen Bilimleri Enstitüsü, Konya.
54. Paulo, F., & Santos, L. (2017). Design of Experiments for Microencapsulation Applications: A Review. Materials Science and Engineering: C, 77, 1327-1340.
55. Peixoto, E. C., Fonseca, L. M., da Rosa Zavareze, E., & Gandra, E. A. (2023). Antimicrobial active packaging for meat using thyme essential oil (Thymus vulgaris) encapsulated on zein ultrafine fibers membranes. Biocatalysis and Agricultural Biotechnology, 51, 102778.
56. Pérez-Chabela, M. L., Lara-Labastida, R., Rodriguez-Huezo, E., & Totosaus, A. (2013). Effect of spray drying encapsulation of thermotolerant lactic acid bacteria on meat batters properties. Food and Bioprocess Technology, 6, 1505-1515.
57. Rodríguez-Huezo, M. E., Estrada-Fernández, A. G., García-Almendárez, B. E., Ludeña-Urquizo, F., Campos-Montiel, R. G., & Pimentel-González, D. J. (2014). Viability of Lactobacillus Plantarum Entrapped in Double Emulsion during Oaxaca Cheese Manufacture, Melting and Simulated İntestinal Conditions. Lwt-Food Science and Technology, 59(2), 768-773.
58. Sagalowicz, L., & Leser, M. E. (2010). Delivery systems for liquid food products. Current Opinion in Colloid & Interface Science, 15(1-2), 61-72.
59. Sidira, M., Galanis, A., Nikolau, A., Kanellaki, M., & Kourkoutas, Y. (2014). Evaluation of Lactobacillus Casei Atcc 393 Protective Effect against Spoilage of Probiotic Dry-Fermented Sausages. Food Control, 42: 315-320.
60. Singh, M., Sharma, R., & Banerjee, U. C. (2002). Biotechnological applications of cyclodextrins. Biotechnology advances, 20(5-6), 341-359.
61. Sobel, R., Versic, R., & Gaonkar, A. G. (2014). Introduction to Microencapsulation and Controlled Delivery in Foods. In Microencapsulation in the Food İndustry (Pp. 3-12). Academic Press.
62. Szente, L., & Szejtli, J. (2004). Cyclodextrins as food ingredients. Trends in Food Science & Technology, 15(3-4), 137-142.
63. Timelsena, Y.P., Akanbi, T.O., Halid, N., Adhikari, B., & Barrow, C. J., “Complex coacervation: Principles, mechanisms and applications in microencapsulation”, International Journal of Biological Macromolecules, 121, 1276-1286, (2019).
64. Topbaş, Ö. (2011). Mikrokapsülasyon Tekniği ile İyileştirici Bandaj Üretimi. Yüksek Lisans Tezi, Dokuz Eylül Üniversitesi Fen Bilimleri Enstitüsü, İzmir.
65. Tosya, F., & Bölek, S. (2022). Encapsulation of Bioactive Compounds in Shalgam and İnvestigation of the Possibilities of their Use in Probiotic Food Production. Food Bioscience, 50, 102166.
66. Turhan, E. U., Erginkaya, Z., Polat, S., & Ozer, E. A. (2017). Design of Probiotic Dry Fermented Sausage (Sucuk) Production with Microencapsulated and Free Cells of Lactobacillus Rhamnosus. Turkish Journal of Veterinary and Animal Sciences, 41: 598-603.
67. Uçar, Y., (2020). Narenciye Kabuğu Esansiyel Yağları Kullanılarak Hazırlanan Mikroenkapsüle Balık Yağı Tozlarının Depolama Süresince Renk ve Duyusal Değişimleri. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(2), 515-526.
68. Ünal, E., & Erginkaya Z. (2010). Probiyotik Mikroorganizmaların Mikroenkapsülasyonu. Gıda, 35(4): 297-304.
69. Wang, M., Wang, C., Gao, F., & Guo, M. (2018). Effects of Polymerised Whey Protein-Based Microencapsulation on Survivability of Lactobacillus Acidophilus La-5 and Physiochemical Properties of Yoghurt. Journal of Microencapsulation, 35, 504-512.
70. Whelehan, M., & Marison, I. W. (2011). Microencapsulation using vibrating technology. Journal of microencapsulation, 28(8), 669-688.
71. Zainal, W. N. H. W., Loganathan, E., & Ganesan, T. (2021). Encapsulation of Freeze-Dried Propolis Powder: Study of in Vitro Disintegration and Dissolution. Indıan Journal of Pharmaceutıcal Educatıon and Research, 55(2), 428-435.
72. Zen, C. K., Tiepo, C. B. V., da Silva, R. V., Reinehr, C. O., Gutkoski, L. C., Oro, T., & Colla, L. M. (2020). Development of functional pasta with microencapsulated Spirulina: Technological and sensorial effects. Journal of the Science of Food and Agriculture, 100(5), 2018-2026.