Synthesis, Cyclization and Nucleophilic Substitution Reactions of Substituted Pyrazole Carboxylic Acid

Öz

Substituted pyrazole carboxylic acid 2a-b derivatives, obtained from 2,3-furandione 1 and benzaldehyde hydrazone 11a-b was converted via reactions of its acid chloride 3a-b. The corresponding ester 6a-b, urea 7a-b, and amide derivatives 4a-b, 8a-b were obtained from the reaction of the acyl chloride of the pyrazole carboxylic acid with various alcohols, urea, and amines. Additionally, the corresponding nitrile derivatives 5 were obtained by extracting water from the amide derivatives (SOCl2 / DMF). Furthermore, cyclization reactions of substituted pyrazole carboxylic acid derivatives using hydrazine were investigated 9 and reaction of 2b decarboxylation product 10.

Anahtar Kelimeler

• cyclization
• decarboxylation
• pyrazole carboxylic acid
• pyrazole

Sübstitüe Pirazol Karboksilik Asit Sentezi, Siklizasyonu ve Nükleofilik Yer Değiştirme Reaksiyonları

Öz

Substitüe pirazol karboksilik asit 2a-b türevleri 2,3-furandion 1 ve benzaldehit hidrazon 11a-b elde edildi. Pirazol karboksilik asit türevleri asit klorürlerine 3a-b dönüştürüldü. Pirazol karboksilik asitin asit klorürü çeşitli alkoller, üre ve aminlerle reaksiyonundan karşılık gelen ester 6a-b, üre 7a-b ve amid 4a-b, 8a-b türevleri elde edildi. Ek olarak, amid türevlerinden (SOCl2/DMF) ile su çekilerek karşılık gelen nitril türevleri 5 elde edildi. Ayrıca pirazol karboksilik asit türevlerinin hidrazin ile siklizasyon reaksiyonlarından 9 ve dekarboksilasyonu sonucu 10 türevlerinin eldesi reaksiyonları araştırılmıştır.

Anahtar Kelimeler

• Siklizasyon
• dekarboksilasyon
• pirazol karboksilit asit
• pirazol

Kaynakça

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