Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections

Ayşe Karacalı Tunç; Togrul Nagiyev; Tülay Kandemir; Melda Meral Öcal; Fatih Köksal

Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections

Öz

Aim: Acinetobacter baumannii is an important pathogen causing concern worldwide with increasing antibiotic resistance. We aimed to provide epidemiological data and molecular differences between multidrug resistant A.baumannii isolates obtained from 7 different centers in Türkiye. Material and Method: One hundred sixty-six multidrug-resistant A.baumannii strains were included in the study. All the isolates were tested for antibiotic susceptibility according to EUCAST criteria. To molecularly confirm the carbapenem-resistant A.baumannii isolates, the specific blaOXA-51-like gene region was detected by polymerase chain reaction (PCR) method. A possible phylogenetic relationship between multi-drug resistant isolates was investigated using Pulsed-field Gel Electrophoresis method. Results: One hundred sixty-six carbapenem-resistant A.baumannii strains were evaluated by the ApaI-PFGE (Pulsed-field gel electrophoresis –PFGE) method using the CHEF-DRII electrophoresis system. A total of 51 clusters were grouped into 142 pulsotypes. Twenty clusters had single members. Thirty-one clusters had multiple members and were identified with the capital letters of the alphabet such as A, B, …, and Z26. It was observed that 40 PFGE profiles showed 100% related. Conclusion: More intense contamination is in question in the provinces with many patients. In four of the seven different centers, more innocent results were obtained in terms of the number of samples, antibiotic resistance and clonal relationship when compared to the other three centers. However, this may be caused by the low population zone and inadequate health services. Regional or multicenter studies are minimal. Thus, further studies involving more centers and larger populations are needed. Consequently, the present study will shed light on future studies and create thriving literature on border regions

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Mikrobiyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Ayşe Karacalı Tunç Bu kişi benim
Türkiye

Togrul Nagiyev Bu kişi benim
Türkiye

Tülay Kandemir Bu kişi benim
Türkiye

Melda Meral Öcal Bu kişi benim
Türkiye

Fatih Köksal Bu kişi benim
Türkiye

Erken Görünüm Tarihi

15 Eylül 2023

Yayımlanma Tarihi

25 Ağustos 2023

Gönderilme Tarihi

9 Nisan 2023

Kabul Tarihi

18 Mayıs 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 13 Sayı: 2

IZ

https://izlik.org/JA36MU25KW

Kaynak Göster

RIS / Bibtex

APA

Karacalı Tunç, A., Nagiyev, T., Kandemir, T., Öcal, M. M., & Köksal, F. (2023). Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections. Kafkas Journal of Medical Sciences, 13(2), 197-205. https://izlik.org/JA36MU25KW

AMA

1.Karacalı Tunç A, Nagiyev T, Kandemir T, Öcal MM, Köksal F. Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections. KAFKAS TIP BİL DERG. 2023;13(2):197-205. https://izlik.org/JA36MU25KW

Chicago

Karacalı Tunç, Ayşe, Togrul Nagiyev, Tülay Kandemir, Melda Meral Öcal, ve Fatih Köksal. 2023. “Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections”. Kafkas Journal of Medical Sciences 13 (2): 197-205. https://izlik.org/JA36MU25KW.

EndNote

Karacalı Tunç A, Nagiyev T, Kandemir T, Öcal MM, Köksal F (01 Ağustos 2023) Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections. Kafkas Journal of Medical Sciences 13 2 197–205.

IEEE

[1]A. Karacalı Tunç, T. Nagiyev, T. Kandemir, M. M. Öcal, ve F. Köksal, “Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections”, KAFKAS TIP BİL DERG, c. 13, sy 2, ss. 197–205, Ağu. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA36MU25KW

ISNAD

Karacalı Tunç, Ayşe - Nagiyev, Togrul - Kandemir, Tülay - Öcal, Melda Meral - Köksal, Fatih. “Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections”. Kafkas Journal of Medical Sciences 13/2 (01 Ağustos 2023): 197-205. https://izlik.org/JA36MU25KW.

JAMA

1.Karacalı Tunç A, Nagiyev T, Kandemir T, Öcal MM, Köksal F. Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections. KAFKAS TIP BİL DERG. 2023;13:197–205.

MLA

Karacalı Tunç, Ayşe, vd. “Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections”. Kafkas Journal of Medical Sciences, c. 13, sy 2, Ağustos 2023, ss. 197-05, https://izlik.org/JA36MU25KW.

Vancouver

1.Ayşe Karacalı Tunç, Togrul Nagiyev, Tülay Kandemir, Melda Meral Öcal, Fatih Köksal. Multicenter Research of the Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Infections. KAFKAS TIP BİL DERG [Internet]. 01 Ağustos 2023;13(2):197-205. Erişim adresi: https://izlik.org/JA36MU25KW