Araştırma Makalesi

Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities

Cilt: 9 Sayı: 2 15 Aralık 2019
Hacer Bayrak *, Yıldız Uygun Cebeci
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Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities

Öz

In this study, antipyrine (4-aminoantipyrine) was selected as the starting material and anti-tubercular activities were compared by carrying out the antipyrine nucleated carbothioamide and 1,2,4-triazole derivatives. The treatment of 4-aminoantipyrine with ethylbromoacetate, hydrazinhydrate and various iso (thio) cyanates, respectively, followed by cyclic reaction by basic reaction resulted in the addition of a second ring of 1,2,4-triazole to the structure. The structures of the synthesized new antipyrine derivatives were determined by spectroscopic methods such as IR, NMR and mass spectrophotometry. For the new compounds synthesized, activity studies were performed against non-Gram bacteria.

Anahtar Kelimeler

Antipyrine, 1 2 4-Triazole, Anti-tubercular Activity

Destekleyen Kurum

Karadeniz Teknik Üniversitesi Bilimsel Araştırma Projesi (KTÜ-BAP)

Proje Numarası

5289

Teşekkür

This work was supported by the Scientific research project of Karadeniz Technical University (KTU-BAP) [grant numbers 5289]. The author also thanks to Prof. Şengül Alpay Karaoğlu for the antitubercular activity studies.

Kaynakça

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  8. Filho, V.C., Correa, Z., Vaz, J.B., Calixto, R.J., Nunes, T.R., Pinheiro, A.D. and Andricopulo, R.A., (1998). Il Framaco, 53, 55-57.
  9. Gürsoy, A., Demirayak, S., Capan, G., Erol, K. and Vurual, K., (2000). Eur. J. Med. Chem., 35, 359-364.
  10. Holla, B., S., Sarojini, B., K., Sooryanarayana, R., Akberali, P., M., Kumari, N., S. and Shetty, V., (2001). II Farmaco, 56, 565-570.

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Araştırma Makalesi

Yazarlar

Yıldız Uygun Cebeci Bu kişi benim
0000-0001-7949-0329
Türkiye

Yayımlanma Tarihi

15 Aralık 2019

Gönderilme Tarihi

16 Eylül 2019

Kabul Tarihi

13 Aralık 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 9 Sayı: 2

DOI

https://doi.org/10.31466/kfbd.620635

IZ

https://izlik.org/JA49CD94SZ

Kaynak Göster

RIS / Bibtex
APA
Bayrak, H., & Uygun Cebeci, Y. (2019). Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. Karadeniz Fen Bilimleri Dergisi, 9(2), 323-334. https://doi.org/10.31466/kfbd.620635
AMA
1.Bayrak H, Uygun Cebeci Y. Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. KFBD. 2019;9(2):323-334. doi:10.31466/kfbd.620635
Chicago
Bayrak, Hacer, ve Yıldız Uygun Cebeci. 2019. “Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities”. Karadeniz Fen Bilimleri Dergisi 9 (2): 323-34. https://doi.org/10.31466/kfbd.620635.
EndNote
Bayrak H, Uygun Cebeci Y (01 Aralık 2019) Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. Karadeniz Fen Bilimleri Dergisi 9 2 323–334.
IEEE
[1]H. Bayrak ve Y. Uygun Cebeci, “Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities”, KFBD, c. 9, sy 2, ss. 323–334, Ara. 2019, doi: 10.31466/kfbd.620635.
ISNAD
Bayrak, Hacer - Uygun Cebeci, Yıldız. “Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities”. Karadeniz Fen Bilimleri Dergisi 9/2 (01 Aralık 2019): 323-334. https://doi.org/10.31466/kfbd.620635.
JAMA
1.Bayrak H, Uygun Cebeci Y. Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. KFBD. 2019;9:323–334.
MLA
Bayrak, Hacer, ve Yıldız Uygun Cebeci. “Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities”. Karadeniz Fen Bilimleri Dergisi, c. 9, sy 2, Aralık 2019, ss. 323-34, doi:10.31466/kfbd.620635.
Vancouver
1.Hacer Bayrak, Yıldız Uygun Cebeci. Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. KFBD. 01 Aralık 2019;9(2):323-34. doi:10.31466/kfbd.620635

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Russian Journal of General Chemistry

https://doi.org/10.1134/S1070363224080188


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