Clinical Significance of CRP/Albumin Value on Hospitalization and Length of Hospital Stay of Patients with Coronavirus-19: A Prospective Study
Abstract
Objective: To investigate the diagnostic and prognostic significance of the C-reactive protein-to-albumin ratio (CAR) in coronavirus disease 2019 (COVID-
19) patients admitted for the first time to a hospital emergency department (ED).
Materials and methods: The study we report herein was a single-center, prospective observational study. A total of 745 participants (385 patients, 360
individuals) were included in the study. The CAR was calculated by dividing the C-reactive protein (CRP; mg/L) value by the albumin value (gr). The data
were analyzed using MedCalc Statistical Software v12.7.0.0 (Ostend, Belgium) and Student’s t-test, chi square test, and Pearson’s correlation coefficient. A
p-value of <0.05was considered statistically significant.
Results: A total of 355 patients were hospitalized, and 30 of them were followed as outpatients. The mean CAR values of the hospitalized patients and the
outpatients were 0.34±0.89 and 0.39±0.72 respectively (95% confidence interval [CI]: -0.31 to 0.40; p=0.796). A 309 patients were hospitalized in wards
and 46, in intensive care units; their mean CAR values were 0.33±0.92 and 0.44±0.74, respectively (95% CI: -0.17 to 0.39; p=0.449). As the CAR value increased,
the length of hospital stay also increased (p<0.0001). At the best cut-off point for COVID-19 diagnosis, CAR was shown to have 82.66% specificity,
69.72% sensitivity, 4.02 positive likelihood, and 0.37 negative likelihood.
Conclusion: The length of stay in the hospital of the COVID-19 patients in the study was closely related to their CAR values obtained at the time of their
first ED admission.s closely related to their CAR values obtained at the time of their first ED admission.
Keywords
Coronavirus disease 2019 , C reactive protein to albumin ratio , first admission , hospital stay
Kaynakça
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