The Relation Between Mean Platelet Volume and Carpal Tunnel Syndrome
Abstract
Objectives:The aim of this study was to evaluate the relationship between Carpal tunnel syndrome (CTS) and mean platelet volume (MPV) in which is raleted with angiogenesis, thrombosis, immunity and inflammation.
Material and Methods:Between 2013 and 2019, 1660 patients underwent mini-open decompression and 1056 healthy individuals were included in the study as study and control grup respectively. After the exclusion criteria are provide, patients were determined 166 CTS patients and 156 control patients in two groups. In the CTS and control groups, MPV, platelet count (PLT), platelet distribution width (PDW), white blood cell(WBC) count, haemoglobin (Hb), ESR and CRP levels were obtained from venous blood samples drawn after 12-h fasting and were recorded retrospectively from the hospital database.In addition, blood samples were taken from the patients in the CTS group at the postoperative 6th and 12th month controls and the values studied before the operation were re-recorded from the file.
Results:Among the CTS patients, only there was a significant difference in the mean MPV at 6 months postoperatively compared to baseline (p=0.027). No significant difference was detected inthe mean MPV at 1 year compared to baseline (p=0.70). In addition, no significant differences were found in MPV values or in other blood parameters (platelet count, white blood count, platelet distribution widthand, haemoglobin) between patients with CTS and controls.
Conclusion:We found that no significant relationship was detected between CTS and MPV in our study. We believe that further prospective studies with larger sample size are needed to elucidate this topic.
Keywords
Carpal Tunnel Syndrome , Mean Platelet Volume , Platelet , Relation.
Kaynakça
- 1. Werner RA, Andary M. Carpal tunnel syndrome: pathophysiology and clinical neurophysiology. Clin Neurophysiol. 2002 Sep;113(9):1373-1381.
- 2. Reinstein L. Hand dominance in carpal tunnel syndrome. Arch Phys Med Rehabil. 1981 May;62(5):202-203.
- 3. Becker J, Nora DB, Gomes I, et al. An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome. ClinNeurophysiol. 2002 Sep;113(9):1429-1434.
- 4. Bath P, Algert C, Chapman N, Neal B. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebro vascular disease. Stroke 2004 Feb;35:622-626.
- 5. Wagner DD, Burger PC. Platelets in inflammation and thrombosis. Arterioscler Thromb Vasc Biol. 2003 Sep;23:2131-2137.
- 6. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008 May;75:291-294.
- 7. Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol 2008 Jun;88:337-340.
- 8. Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets. 2014 Mar;25:81-85.
- 9. Parh Y, Schoene N, Harris W. Mean platelet volume as a indicator of platelet activation: Methodological Issues. Platelets. 2002 Jul;13:301-306.
- 10. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet rich plasma: from basic science to clinical applications. Am J Sports Med. 2009 Oct;37:2259-2272.