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FİBROMİYALJİ SENDROMUNDA ELEKTROAKUPUNKTUR İLE VENLAFAKSİN TEDAVİSİNİN KARŞILAŞTIRILMASI

Yıl 2015, Cilt: 10 Sayı: 3, 0 - 0, 14.10.2016

Öz

Bu çalışmanın amacı, fibromiyalji sendromlu hastaların tedavisinde; elektroakupunktur (EA) ile venlafaksinin tedavi etkinliğini araştırmak ve karşılaştırmaktır. FMS'li 60 hasta rastgele, eşit iki gruba ayrıldı. Birinci gruba EA; haftada 3 gün, her seans 20 dakika olmak üzere 15 seans uygulandı. İkinci gruba ise Venlafaksin 75 mg/gün, tek doz, 45 gün süreyle kullandırıldı.

Hastaların, tedavi öncesi ve tedavi sonrası bulguları kaydedildi.

Bağımlı ve bağımsız gruplar için Student'in t testi kullanıldı. Bu analizlerde, tedavi öncesi tutukluk ve Beck depresyon envanteri parametrelerinde gruplar arası fark olduğu (p<0.05) görüldü. Diğer parametrelerde anlamlı fark yoktu (p>0.05).

EA tedavisi, tutukluk parametresinde çok anlamlı (p<0.01), diğer parametrelerde ise ileri derecede anlamlı (p<0.001) etki oluşturdu.

Venlafaksin tedavisinde, hassas nokta sayısında çok anlamlı (p<0.01), diğer parametrelerinde ise ileri derecede anlamlı (p<0.001) düzelmeler oldu.

Uygulanan tedavi yöntemleri, biribirleriyle karşılaştırdığında; tutukluk, yorgunluk, hassas nokta sayısı parametrelerinde anlamlı bir fark olmadığı (p>0.05) anlaşıldı. Uyku bozukluğu parametresinde ise her iki yöntemin eşit etkili oldukları sonucuna varıldı. Vizüel analog skala (VAS) ve Beck depresyon ölçeği (BDE) parametrelerinde ise EA tedavisi, venlafaksin tedavisine göre çok anlamlı (p<0.01) düzelme sağladı.

Sonuç olarak kısa dönemde her iki tedavi yönteminin de fibromiyalji sendromunun tedavisinde etkili oldukları görülmüştür. Ancak VAS ve BDE parametrelerinde EA tedavisinin, venlafaksin tedavisine oranla daha etkili olduğu sonucuna varılmıştır.

Kaynakça

  • Mannerkorpi K, Svantesson U, Broberg C. Relationships between performance-based tests and patients' ratings of activity limitations, self-efficacy, and pain in fibromyalgia. Archives of physical medicine and rehabilitation 2006;87:259-64.
  • Bennett RM, Friend R, Marcus D, Bernstein C, Han BK, Yachoui R, et al. Criteria for the diagnosis of fibromyalgia: validation of the modified 2010 preliminary American College of Rheumatology criteria and the development of alternative criteria. Arthritis care & research 2014;66:1364-73.
  • VanderWeide LA, Smith SM, Trinkley KE. A systematic review of the efficacy of venlafaxine for the treatment of fibromyalgia. Journal of clinical pharmacy and therapeutics 2014.
  • Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA : the journal of the American Medical Association 2004;292:2388-95.
  • Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis and rheumatism 1991;34:552-60.
  • Okifuji A, Hare BD. Management of fibromyalgia syndrome: review of evidence. Pain and therapy 2013;2:87-104.
  • Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). NeuroImage 2009;47:1077-85.
  • Gazi MC, Issy AM, Avila IP, Sakata RK. Comparison of acupuncture to injection for myofascial trigger point pain. Pain practice : the official journal of World Institute of Pain 2011;11:132-8.
  • Toth PP, Urtis J. Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clinical therapeutics 2004;26:1355-67.
  • Deluze C, Bosia L, Zirbs A, Chantraine A, Vischer TL. Electroacupuncture in fibromyalgia: results of a controlled trial. Bmj 1992;305:1249-52.
  • Lundeberg T, Lund I. Are reviews based on sham acupuncture procedures in fibromyalgia syndrome (FMS) valid? Acupuncture in medicine : journal of the British Medical Acupuncture Society 2007;25:100-6.
  • Yunus MB, Aldag JC. Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. BMJ 1996;312:1339.
  • Stehlik R, Arvidsson L, Ulfberg J. Restless legs syndrome is common among female patients with fibromyalgia. European neurology 2009;61:107-11.
  • Bradley LA. Pathophysiologic mechanisms of fibromyalgia and its related disorders. The Journal of clinical psychiatry 2008;69 Suppl 2:6-13.
  • Togo F, Natelson BH, Cherniack NS, FitzGibbons J, Garcon C, Rapoport DM. Sleep structure and sleepiness in chronic fatigue syndrome with or without coexisting fibromyalgia. Arthritis research & therapy 2008;10:R56.
  • Bradley LA. Pathophysiology of fibromyalgia. The American journal of medicine 2009;122:S22-30.
  • Buesing AR. A conservative, cost-effective approach to fibromyalgia. JAAPA : official journal of the American Academy of Physician Assistants 2005;18:32-7; quiz 45-6.
  • Crawford BK, Piault EC, Lai C, Bennett RM. Assessing fibromyalgia-related fatigue: content validity and psychometric performance of the Fatigue Visual Analog Scale in adult patients with fibromyalgia. Clinical and experimental rheumatology 2011;29:S34-43.
  • Bennett RM, Russell J, Cappelleri JC, Bushmakin AG, Zlateva G, Sadosky A. Identification of symptom and functional domains that fibromyalgia patients would like to see improved: a cluster analysis. BMC musculoskeletal disorders 2010;11:134.
  • Kindler LL, Bennett RM, Jones KD. Central sensitivity syndromes: mounting pathophysiologic evidence to link fibromyalgia with other common chronic pain disorders. Pain management nursing : official journal of the American Society of Pain Management Nurses 2011;12:15-24.
  • Hannonen P, Malminiemi K, Yli-Kerttula U, Isomeri R, Roponen P. A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder. British journal of rheumatology 1998;37:1279-86.
  • Hench PK. Evaluation and differential diagnosis of fibromyalgia. Approach to diagnosis and management. Rheumatic diseases clinics of North America 1989;15:19-29.
  • Carette S, McCain GA, Bell DA, Fam AG. Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study. Arthritis and rheumatism 1986;29:655-9.
  • Güneş A. Servikodorsal fibromiyaljili hastalarda akupunktur ile konnektif doku masajımn karşılaştırılması,. Yüksek lisans tezi 1998.;Y.Y.Ü. Sağlık Bilimler Enstitüsü, Van.
  • Bezer J. Fibromiyalji sendromunda aerobik egzersiz ve amitriptilinin etkinliği. Uzmanlık tezi İÜİTF FTR AD, İstanbul 1996.
  • Fricton RJ. Etiopathogenesis of fibromyalgia,. 1990;Advances in pain research & therapy,New York,: 16, 7, Raven press, .
  • Daryanızadeh H. Fibromiyalji sendromunun tedavisinde elektroakupunktur ve ultrason tedavilerinin etkinlikleri,. 1999;Uzmanlık tezi, İ.Ü.İ.T.F., FTR.AD., İstanbul, .
  • Lesley MA. Venlafaxine joins ranks of psychotropic therapies to treat fibromyalgia, . Primary psychiatry january, 1996;62-66.
  • Croft P, Schollum J, Silman A. Population study of tender point counts and pain as evidence of fibromyalgia. Bmj 1994;309:696-9.
  • Hudson JI, Arnold LM, Bradley LA, Choy EH, Mease PJ, Wang F, et al. What makes patients with fibromyalgia feel better? Correlations between Patient Global Impression of Improvement and changes in clinical symptoms and function: a pooled analysis of 4 randomized placebo-controlled trials of duloxetine. The Journal of rheumatology 2009;36:2517-22.
  • Kravitz HM, Katz R, Kot E, Helmke N, Fawcett J. Biochemical clues to a fibromyalgia-depression link: imipramine binding in patients with fibromyalgia or depression and in healthy controls. The Journal of rheumatology 1992;19:1428-32.
  • Kuran BÖ, M. Fibromiyalji sendromunda tinanidine ve ultrason tedavisinin etkinliklerinin karşılaştırılması. FTR Derg 8 1994 29-32.
Yıl 2015, Cilt: 10 Sayı: 3, 0 - 0, 14.10.2016

Öz

Kaynakça

  • Mannerkorpi K, Svantesson U, Broberg C. Relationships between performance-based tests and patients' ratings of activity limitations, self-efficacy, and pain in fibromyalgia. Archives of physical medicine and rehabilitation 2006;87:259-64.
  • Bennett RM, Friend R, Marcus D, Bernstein C, Han BK, Yachoui R, et al. Criteria for the diagnosis of fibromyalgia: validation of the modified 2010 preliminary American College of Rheumatology criteria and the development of alternative criteria. Arthritis care & research 2014;66:1364-73.
  • VanderWeide LA, Smith SM, Trinkley KE. A systematic review of the efficacy of venlafaxine for the treatment of fibromyalgia. Journal of clinical pharmacy and therapeutics 2014.
  • Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA : the journal of the American Medical Association 2004;292:2388-95.
  • Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis and rheumatism 1991;34:552-60.
  • Okifuji A, Hare BD. Management of fibromyalgia syndrome: review of evidence. Pain and therapy 2013;2:87-104.
  • Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs). NeuroImage 2009;47:1077-85.
  • Gazi MC, Issy AM, Avila IP, Sakata RK. Comparison of acupuncture to injection for myofascial trigger point pain. Pain practice : the official journal of World Institute of Pain 2011;11:132-8.
  • Toth PP, Urtis J. Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clinical therapeutics 2004;26:1355-67.
  • Deluze C, Bosia L, Zirbs A, Chantraine A, Vischer TL. Electroacupuncture in fibromyalgia: results of a controlled trial. Bmj 1992;305:1249-52.
  • Lundeberg T, Lund I. Are reviews based on sham acupuncture procedures in fibromyalgia syndrome (FMS) valid? Acupuncture in medicine : journal of the British Medical Acupuncture Society 2007;25:100-6.
  • Yunus MB, Aldag JC. Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. BMJ 1996;312:1339.
  • Stehlik R, Arvidsson L, Ulfberg J. Restless legs syndrome is common among female patients with fibromyalgia. European neurology 2009;61:107-11.
  • Bradley LA. Pathophysiologic mechanisms of fibromyalgia and its related disorders. The Journal of clinical psychiatry 2008;69 Suppl 2:6-13.
  • Togo F, Natelson BH, Cherniack NS, FitzGibbons J, Garcon C, Rapoport DM. Sleep structure and sleepiness in chronic fatigue syndrome with or without coexisting fibromyalgia. Arthritis research & therapy 2008;10:R56.
  • Bradley LA. Pathophysiology of fibromyalgia. The American journal of medicine 2009;122:S22-30.
  • Buesing AR. A conservative, cost-effective approach to fibromyalgia. JAAPA : official journal of the American Academy of Physician Assistants 2005;18:32-7; quiz 45-6.
  • Crawford BK, Piault EC, Lai C, Bennett RM. Assessing fibromyalgia-related fatigue: content validity and psychometric performance of the Fatigue Visual Analog Scale in adult patients with fibromyalgia. Clinical and experimental rheumatology 2011;29:S34-43.
  • Bennett RM, Russell J, Cappelleri JC, Bushmakin AG, Zlateva G, Sadosky A. Identification of symptom and functional domains that fibromyalgia patients would like to see improved: a cluster analysis. BMC musculoskeletal disorders 2010;11:134.
  • Kindler LL, Bennett RM, Jones KD. Central sensitivity syndromes: mounting pathophysiologic evidence to link fibromyalgia with other common chronic pain disorders. Pain management nursing : official journal of the American Society of Pain Management Nurses 2011;12:15-24.
  • Hannonen P, Malminiemi K, Yli-Kerttula U, Isomeri R, Roponen P. A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder. British journal of rheumatology 1998;37:1279-86.
  • Hench PK. Evaluation and differential diagnosis of fibromyalgia. Approach to diagnosis and management. Rheumatic diseases clinics of North America 1989;15:19-29.
  • Carette S, McCain GA, Bell DA, Fam AG. Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study. Arthritis and rheumatism 1986;29:655-9.
  • Güneş A. Servikodorsal fibromiyaljili hastalarda akupunktur ile konnektif doku masajımn karşılaştırılması,. Yüksek lisans tezi 1998.;Y.Y.Ü. Sağlık Bilimler Enstitüsü, Van.
  • Bezer J. Fibromiyalji sendromunda aerobik egzersiz ve amitriptilinin etkinliği. Uzmanlık tezi İÜİTF FTR AD, İstanbul 1996.
  • Fricton RJ. Etiopathogenesis of fibromyalgia,. 1990;Advances in pain research & therapy,New York,: 16, 7, Raven press, .
  • Daryanızadeh H. Fibromiyalji sendromunun tedavisinde elektroakupunktur ve ultrason tedavilerinin etkinlikleri,. 1999;Uzmanlık tezi, İ.Ü.İ.T.F., FTR.AD., İstanbul, .
  • Lesley MA. Venlafaxine joins ranks of psychotropic therapies to treat fibromyalgia, . Primary psychiatry january, 1996;62-66.
  • Croft P, Schollum J, Silman A. Population study of tender point counts and pain as evidence of fibromyalgia. Bmj 1994;309:696-9.
  • Hudson JI, Arnold LM, Bradley LA, Choy EH, Mease PJ, Wang F, et al. What makes patients with fibromyalgia feel better? Correlations between Patient Global Impression of Improvement and changes in clinical symptoms and function: a pooled analysis of 4 randomized placebo-controlled trials of duloxetine. The Journal of rheumatology 2009;36:2517-22.
  • Kravitz HM, Katz R, Kot E, Helmke N, Fawcett J. Biochemical clues to a fibromyalgia-depression link: imipramine binding in patients with fibromyalgia or depression and in healthy controls. The Journal of rheumatology 1992;19:1428-32.
  • Kuran BÖ, M. Fibromiyalji sendromunda tinanidine ve ultrason tedavisinin etkinliklerinin karşılaştırılması. FTR Derg 8 1994 29-32.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Bölüm Makaleler
Yazarlar

Ali Özgür Bu kişi benim

Adnan Demirel

Murat Baykara

Yayımlanma Tarihi 14 Ekim 2016
Gönderilme Tarihi 31 Ekim 2014
Yayımlandığı Sayı Yıl 2015 Cilt: 10 Sayı: 3

Kaynak Göster

AMA Özgür A, Demirel A, Baykara M. FİBROMİYALJİ SENDROMUNDA ELEKTROAKUPUNKTUR İLE VENLAFAKSİN TEDAVİSİNİN KARŞILAŞTIRILMASI. KSÜ Tıp Fak Der. Ekim 2016;10(3).