Fibromiyalji Hastalarında D Vitamini Eksikliğinin Fiziksel Semptomlara Etkisinin İncelenmesi

Yıl 2021, Cilt: 16 Sayı: 3, 421 - 431, 01.11.2021

İhsan Karabulut Deniz Kocamaz Begümhan Turhan

https://doi.org/10.17517/ksutfd.818963

Öz

Amaç: Amacımız fibromiyalji hastalarında D vitamini eksikliğinin fiziksel semptomlara etkisini inceleyen araştırmaları taramaktır.
Gereç ve Yöntemler: Çalışmada Pubmed ve Google Scholar veri tabanlarında anahtar kelimeler ile uyumlu tüm Türkçe ve İngilizce çalışmalar tarandı. Anahtar kelime olarak İngilizce dilinde ‘fibromyalgia’ ve ‘Vitamin D’ kelimeleri Türkçe dilinde ‘fibromiyalji’ ve ‘D vitamini’ anahtar kelimeleri kullanıldı.
Bulgular: 2 anahtar kelimenin başlıkta yer aldığı ve fiziksel bulguları inceleyen çalışma sayısı 20’dir. Araştırmaya dahil edilen 2230 bireyin yer aldığı çalışmaların dokuzu ulusal, 11’i uluslararası çalışmalardı. 20 çalışmadan sekizi hasta grubundan, 12’si hasta ve kontrol grubundan oluşmaktadır. Altı çalışmada D vitamini replasman tedavisi bulunmaktaydı. Çalışmalarda ağrı, uyku durumu, yorgunluk, fibromiyalji etkinliği, yaşam kalitesi, anksiyete, depresyon, cinsellik, denge parametreleri incelenmiştir. Ağrı, yorgunluk, uyku durumu en fazla incelenen fiziksel bulgulardır.
Sonuç: Fibromiyalji hastalarında D vitamini eksikliğinin ağrıyı ve fibromiyalji belirtilerini arttırdığı, yaşam kalitesini, uyku süresini ve dengeyi azalttığı, yorgunluk düzeyi açısından anlamlı bir farklılık oluşturmadığı gözlenmektedir.

Anahtar Kelimeler

Fibromiyalji, D vitamini, Fiziksel bulgular

Investigation of the Effect of Vitamin D Deficiency on Physical Symptoms in Fibromyalgia Patients: Systematic Review

Öz

Aim: Our aim is to investigate the studies investigating the effect of vitamin D deficiency on physical symptoms in fibromyalgia patients.
Materials and Methods: All studies that were according with keywords in Turkish and English languages which were published in Pubmed and Google Scholar databases were scanned. The keywords 'fibromyalgia' and 'Vitamin D' were used as keywords in the English language, the keywords 'fibromiyalji' and 'D vitamini' were used in the Turkish language.
Results: The number of studies with 2 keywords in the title and examining the physical findings is 20. Of the 2230 individuals included in the study, 9 were national and 11 were international studies. Of the 20 studies, 8 consisted of the patient group and 12 consisted of the patient and control groups. Six studies had vitamin D replacement therapy. In the studies, pain, sleepiness, fatigue, fibromyalgia efficacy, quality of life, anxiety, depression, sexuality, balance parameters were examined. Pain, fatigue, sleep state are the most frequently examined physical findings.
Conclusion: It is observed that vitamin D deficiency in fibromyalgia patients increases pain and fibromyalgia symptoms, decreases quality of life, sleep time and balance, and does not make a significant difference in terms of fatigue level.

Anahtar Kelimeler

fibromyalgia, Vitamin D, Physical findings

Kaynakça

• 1. Clauw DJ. Fibromyalgia: a clinical review. JAMA 2014;311(15):1547–1555.
• 2. Wolfe F, Smythe HA, Yunus MB, Bennett RB, Bombardier C, Goldenberg DL et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia report of the multicenter criteria committee. Arthritis Rheum 1990;33(2):160-172.
• 3. Sarzi-Puttini P, Atzeni F, Salaffi F, Cazzola M, Benucci M, Mease PJ. Multidisciplinary approach to fibromyalgia: what is the teaching? Best Pract Res Clin Rheumatol 2011;25(2):311-319.
• 4. Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: Metabolism. Endocrinol Metab Clin North Am 2010;39(2):243-253.
• 5. Wacker M, Holick MF. Vitamin D-Effects on Skeletal and Extraskeletal Health and the Need for Supplementation. Nutrients 2013;5(1):111-148.
• 6. Baygutalp NK, Baygutalp F, Seferoglu B, Bakan E. The relation between serum vitamin D levels and clinical findings of fibromyalgia syndrome. Dicle Med J 2014;41(3):446-450.
• 7. Labeeb A, Al-Sharaki DR. Detection of serum 25(OH)-vitamin D level in the serum of women with fibromyalgia syndrome and its relation to pain severity. Egypt Rheumatol Rehabil 2015;(42):196–200.
• 8. Armstrong DJ, Meenagh GK, Bickle I, Lee ASH, Curran ES, Finch MB. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. J Clin Rheumatol 2007;(26):551–554.
• 9. Ulusoy H, Sarica N, Arslan S, et al. Serum vitamin D status and bone mineral density in fibromyalgia. Bratisl Lek Listy 2010;111(11):604-609.
• 10. Matthana MH. The relation between vitamin D deficiency and fibromyalgia syndrome in women. Saudi Med J 2011;32(9):925-929.
• 11. Okumus M, Koybası M, Tuncay F. et al. Fibromyalgia syndrome: is it related to vitamin D deficiency in premenopausal female patients? Pain Manag Nurs 2013;14(4):156-163.
• 12. Gheita TA, Sayed S, Gheita HA, Kenawy SA. Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome. Int J Rheum Dis 2016;19(3):294-299.
• 13. Wepner F, Scheuer R, Schuetz-Wieser B. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain 2014;155(2):261-268.
• 14. Abou-Raya S, Abou-Raya A, Helmii M. Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia: Randomized Controlled Trial. Ann Rheum Dis EULAR 2014: Scientific Abstracts Poster Presentations. Fibromyalgia and pain in rheumatic diseases. doi: 10.1136/annrheumdis-2014-eular.2767.
• 15. Ozcan DS, Oken O, Aras M, Koseoglu BF. Vitamin D levels in women with fibromyalgia and relationship between pain, depression, and sleep. Turk J Phys Med Rehab 2014;60:329-334.
• 16. Solmaz D, Avci O, Yalcin BC, Kara SP, Oran M. Vitamin D Deficiency Might Contribute Fatigue and Disease Activity in Patients with Fibromyalgia. Ann Rheum Dis 2015;74:1215.
• 17. Yilmaz R, Salli A, Cingoz HT, Kucuksen S, Ugurlu H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis 2016;19(12):1255-1262.
• 18. Aksoy MK, Altan L, Metin BÖ. The relationship between balance and vitamin 25(OH)D in fibromyalgia patients. Mod Rheumatol 2016;27(5):868-874.
• 19. Maafi AA, Ghavidel-Parsa B, Haghdoost A, Aarabi Y, Haijabbasi A, Maasoleh IS et al. Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation. Korean J Pain 2016;29(3) :172-178.
• 20. Yıldırım T, Solmaz D, Akgol G, Ersoy Y. Relationship between mean platelet volume and vitamin D deficiency in fibromyalgia. J Biomed Res 2016;27:(4).
• 21. Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia. Eurasian J Med 2017; 49(2):113-117.
• 22. Mirzaei A, Zabihiyeganeh M, Jahed SA, Khiabani E, Nojomi M, Ghaffari S. Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. Med J Islam Repub Iran 2018;32:29.
• 23. De Carvalho JF, da Rocha Araújo FAG, da Mota LMA, Aires RB, de Araujo RP. Vitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary Results. Isr Med Assoc J 2018;20(6):379-381.
• 24. Amin OA, Abouzeid SM, Ali SA, Amin BA, Alswat KA. Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome.Neuropsychiatr Dis Treat 2019;15:1421-1426.
• 25. D'Souza RS, Lin G, Oh T, Vincent A, Orhurhu V, Jiang L, et al. Fibromyalgia Symptom Severity and Psychosocial Outcomes in Fibromyalgia Patients with Hypovitaminosis D: A Prospective Questionnaire Study. Pain Med 2020;p:377.
• 26. Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain 2017;30(4):250-257.
• 27. Hsiao MY, Hung CY, Chang KV, Han DS, Wang TG. Is Serum Hypovitaminosis D Associated with Chronic Widespread Pain Including Fibromyalgia? A Meta-analysis of Observational Studies. Pain Physician 2015;18(5):877-887.
• 28. Kowalski PC, Dowben JS, Keltner. Biological perspectives: pain: it's not all in your head. Perspect Psychiatr Care 2013;50(1):3-6.