Inflammation in Chronic Psychiatric Patients: Neutrophil/Lymphocyte Ratios, Platelet/Lymphocyte Ratios, and Mean Platelet Volume

Yıl 2023, Cilt: 18 Sayı: 2, 53 - 59, 12.07.2023

Figen Unal Demir , Filiz Özsoy , Esma Akpınar Aslan

https://doi.org/10.17517/ksutfd.1127281

Cited By: 1

Öz

Objective: The aim of this study was to examine the Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratios (PLR), and Mean Platelet Volume
(MPV), red blood cell distribution width (RDW) and leukocyte cell levels of inpatients with mental illness by comparing them with each other and healthy
controls.
Materials and Methods: A total of 600 people were included in our study, 500 of whom were taken as the patient and 100 as the control group. The diagnosis
of patients according to DSM-5-Criteria were 34.8% Schizophrenia, 21% had Generalized-Anxiety-Disorder, 14.4% had Bipolar-Affective-Disorder,
14% had Major-Depressive-Disorder, 7.2% had Adjustment-Disorder, 4.2% had Schizoaffective-Disorder, 3.6% had other psychiatric illnesses.
Results: It was seen that hemoglobin, platelet, monocyte, blood platelet distribution (PCT), percentage account of RDW (RDW-CV) did not have statistically
significant differences between groups (p values were 0.082, 0.214, 0.526, 0.082, 0.771, respectively). The lymphocyte, eosinophil, basophil, MPV,
standard deviation of RDW (RDW-SD) were higher compared with healthy controls (p values were 0.002, 0.003, <0.001, <0.001, 0.003, 0.003, respectively).
NLR and PLR were low in the patient group compared to healthy controls (p<0.001).
Conclusion: It was found that some of the inflammation parameters of chronic with mental illness were different from those of healthy controls. However,
further prospective studies are needed to better reveal the relationship between inflammatory parameters and mental illnesses..

Anahtar Kelimeler

Inflammation, neutrophil/lymphocyte rates, platelet/lymphocyte ratios, schizophrenia, bipolar disorder.

Kronik Psikiyatrik Hastalarda Enflamasyon: Nötrofil/Lenfosit Oranları, Trombosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Öz

Amaç: Bu çalışmanın amacı ruhsal hastalık tanısı olan ve yatarak tedavi gören hastaların nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranı (PLO), kırmızı
kan hücre dağılımı (RDW) ve lökosit hücre düzeylerini sağlıklı kontroller ve bir birleri ile karşılaştırarak incelemektir.
Gereç ve Yöntemler: Çalışmamıza 600 kişi dâhil edildi. Hasta grubu olarak 500 kişi, sağlıklı kontrol grubu olarak 100 kişi alındı. Hastaların DSM-5 kriterlerine
göre tanıları sırası ile; 174 (%34.8) şizofreni, 105 (%21) yaygın anksiyete bozukluğu, 72 (%14.4) bipolar affektif bozukluk, 70 (%14) majör depresif
bozukluk, 36 (%7.2) uyum bozukluğu, 21 (%4.2) şizoaffektif bozukluk ve 18 (%3.6) diğer psikiyatrik hastalıklar idi. Tüm katılımcıların demografik veri
formu ve laboratuvar parametreleri için hemogram testleri alınmıştır.
Bulgular: Çalışmamıza katılanlardan; 315 (%52.5) kişi kadın, 285 (%47.5) kişi erkekti. Yaşları 18-65 arasında değişmekle birlikte, ortalaması 39.6±15.22
idi. Laboratuvar parametrelerinin dağılımı incelendiğinde; hemoglobin, platelet, monosit, kan platelet dağılım genişliği (PCT), RDW-standart sapma üzerinden
yüzdeli hesabı (RDW-CV) değerleri gruplar arasında istatistiksel olarak anlamlı farklılık tespit edilmedi (Sırası ile p değerleri; 0.082, 0.214, 0.526,
0.082, 0.771 idi). Hastaların lenfosit, eozinofil, bazofil, ortalama platelet hacmi (MPV), alyuvarlar hücre boyutunun standart sapma olarak hesabı (RDWSD)
değerleri sağlıklı kontroller ile karşılaştırıldığında yüksek olarak hesaplandı (sırası ile p değerleri; 0.002, 0.003, <0.001, <0.001, 0.003 idi). NLO ve
PLO hasta grubunda sağlıklı kontrollere göre düşüktü (sırası ile p değeri her iki ölçüm için de <0.001).
Sonuç: Çalışmamızda kronik ruhsal hastalığı olan bireylerin bazı inflamasyon parametrelerinin sağlıklı kontrollerden farklı olduğu saptanmıştır. Ancak
inflamasyon parametrelerinin ruhsal hastalıklar ile olan ilişkisini daha iyi ortaya koyabilmek için prospektif nitelikte daha ileri araştırmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

İnflamasyon, nötrofil/lenfosit oranları, platelet/lenfosit oranları, şizofreni, bipolar bozukluk.

Kaynakça

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