Evaluation Depressive Symptoms in Patients with Euthyroid Hashimoto’s Thyroiditis and Patients with Subclinical Hypothyroidism

Öz

Objective: Hypothyroidism is a common endocrine disorder in general population. This study aims to compare depressive symptoms of patients with euthyroid Hashimoto hypothyroidism, patients with new onset subclinical hypothyroidism and healthy controls.

Methods: Study was conducted at Kocaeli State Hospital Internal Medicine Clinic between 2017-2019. Patients who were treated for hypothyroidism at Kocaeli State Hospital Internal Medicine Clinic were screened and eligible patients were divided into two groups: patients with euthyroid Hashimoto thyroiditis and patients with subclinical hypothyroidism. Beck depression inventory was applied to the groups. Also, a control group was generated and applied the same inventory.

Results: Forty-three patients and 31 healthy controls were recruited; 32 had euthyroid Hashimoto thyroiditis whereas 11 had subclinical hypothyroidism. Mean thyroid stimulating hormone (TSH) level of patients was 2.3±0.9 mU/L and 8.2±2.7 mU/L, respectively. Mean Beck depression inventory score of the patients was 14.1±8.9. Mean score of the control group was 6.4±5.2. Although there was no difference between scores of controls and subclinical hypothyroid patients, there was statistically significant difference between controls and euthyroid patients (p<0.01). There was no statistically significant difference between subclinical hypothyroid patients and euthyroid patients. Fifteen patients had score ≥17. Thirty four percent of the euthyroid patients (n=11) and 36% of subclinical hypothyroid patients (n=4) had moderate and high depressive symptoms.

Conclusion: Depression is not uncommon in patients with hypothyroidism. It should be investigated when necessary.

Anahtar Kelimeler

• Hashimoto thyroiditis,subclinic hypothyroidism,depression

Ötiroid Hashimoto Tiroiditi ve Subklinik Hipotiroidisi Olan Hastalarda Depresif Semptomların Değerlendirilmesi

Öz

Amaç: Hipotiroidi toplumda en sık görülen endokrinolojik hastalıklardan birisidir. Bu çalışmada, Hashimoto hipotiroiditine bağlı tedavi atında ötiroid olan hastalar ile subklinik hipotirodi tanısı alan hastalarda depresif semptom varlığı araştırılarak sağlıklı kontroller ile karşılaştırıldı.

Yöntem: Bu çalışma Kocaeli Devlet Hastanesi İç Hastalıkları Kliniği’nde 2017-2019 yılları arasında yürütüldü. Kocaeli Devlet Hastanesi İç Hastalıkları Kliniği’nde tiroid hastalığı nedeni ile takip edilen hastalar, tiroid fonksiyon testi sonuçlarına göre tedavi altında ötiroid olan Hashimoto tiroiditi olanlar ve subklinik hipotiroidisi olanlar şeklinde ikiye ayrıldı. Her iki gruba da Beck depresyon ölçeği uygulandı. Ayrıca bir kontrol grubu oluşturularak aynı ölçek uygulandı.

Bulgular: Çalışmaya toplam 43 hasta ve 31 kontrol alındı. Bunlardan 32’si ötiroid seyreden Hashimoto tiroiditi olan, 11’i de subklinik hipotiroidisi olan hastalardı. Ötiroid hastaların ortalama tiroid stimulan hormon (TSH) düzeyi 2,3±0,9 mU/L iken subklinik hipotiroidisi olan hastalarınki 8,2±2,7 mU/L idi. Hastaların ortalama Beck depresyon skoru 14,1±8,9 idi. Kontrol grubunun ortalama Beck depresyon skoru 6,4±5,2 olarak saptandı. Kontrol grubu ile ötiroid Hashimoto grubu arasında Beck depresyon skoru açısından anlamlı fark saptanırken (p<0,01), ötiroid Hashimotolu hastalar ile subklinik hipotiroidisi olanlar arasındaki fark anlamlılık arz etmedi. Toplam 15 hastanın (%35) depresyon skoru ≥17 olarak saptandı. Ötiroid hastaların %34’ünde (n=11), subklinik hipotiroidisi olan hastaların %36’sında (n=4) orta ve yüksek seviyede depresif semptomlar görüldü.

Sonuç: Depresyon hipotiroidi hastalarında nadir görülen bir durum değildir. Gerekli durumlarda araştırılmalıdır.

Anahtar Kelimeler

• Hashimoto tiroiditi,subklinik hipotiroidizm,depresyon

Kaynakça

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