Effects of Imidazopyridine Derivatives on Cancer Cell Signaling

Öz

The limited effectiveness of conventional chemotherapeutics used in cancer treatment requires the discovery of new agents. Compounds with imidazopyridine scaffolds have promising potential for the development of new agents because they are open to various chemical modifications. Intracellular signaling pathways are essential in normal cell physiology, and their defects play a role in the pathogenesis of many diseases, including cancer. Although numerous studies have demonstrated the cytotoxic and apoptotic properties of imidazopyridines on cancer cells, a limited number of studies have aimed to investigate the effects of these compounds on signaling pathways. Obtained data show that this group of compounds is effective on signaling pathways.

Anahtar Kelimeler

• Cancer
• imidazopyridine
• signaling

İMİDAZOPİRİDİN TÜREVLERİNİN KANSER HÜCRE SİNYALİNDEKİ ETKİLERİ

Öz

Kanser tedavisinde kullanılan konvansiyonel etkinliklerinin sınırlı olması yeni ajanların keşfini gerektirmektedir. İmidazopiridin iskelesine sahip bileşikler çeşitli kimyasal modifikasyonlara açık olması sebebiyle yeni ajanların geliştirilmesi için umut verici potansiyele sahiptir. Hücre içi sinyal yolakları normal hücre fizyolojisinde gerekli olup bozuklukları kanser dahil çok sayıda hastalığın patogenezinde rol oynar. Çok sayıda çalışma ile imidazopiridinlerin kanser hücreleri üzerinde sitotoksik ve apoptotik özellikleri gösterilmiş olsa da sınırlı sayıda çalışma bu bileşiklerin sinyal yolakları üzerindeki etkilerini araştırmayı hedeflemiştir. Elde edilen veriler bu grup bileşiklerin sinyal yolları üzerinde etkili olduğunu göstermektedir.

Anahtar Kelimeler

• Kanser
• imidazopiridin
• sinyal

Kaynakça

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