INSULIN RESISTANCE, SERUM ADIPONECTIN AND ADIPONECTIN GENE POLYMORPHISM IN FIRST-DEGREE RELATIVES OF INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS

Öz

Objective: Investigation of insulin resistance, serum adiponectin levels, and adiponectin gene polymorphism in first-degree relatives of Type 2 Diabetes Mellitus (T2DM) patients. Material and Methods: A total of 142 individuals (34 males, 108 females) meeting the inclusion criteria for first-degree relatives of T2DM patients were included in the study. A control group consisting of 80 (15 males, 65 females) healthy adults was formed. Blood pressure, waist and hip circumferences were measured for all participants. Fasting glucose and insulin levels, lipid profile, serum adiponectin level, and adiponectin gene polymorphism were analyzed, and an oral glucose tolerance test with 75 grams of glucose was conducted. Insulin resistance was calculated using the HOMA-IR method. Results: HOMA-IR value, total cholesterol, LDL-cholesterol, and triglyceride levels were significantly higher, while HDL-cholesterol level was significantly lower in first-degree relatives of T2DM patients compared to the control group. Glucose tolerance impairment was more prevalent in the study group. Serum adiponectin levels were significantly lower in the study group. Adiponectin gene polymorphism showed a similarity between the two groups. Conclusion: The higher HOMA-IR and lower serum adiponectin levels detected in first-degree relatives of T2DM patients suggest impairment in metabolic functions in these individuals. However, adiponectin gene polymorphism showed a similarity between the study and control groups. Further extensive studies supported by single gene polymorphism and multi-allele investigations, taking into account environmental factors and lifestyle, are needed to determine the effect of adiponectin gene polymorphism on diabetes development and impaired metabolic functions.

Anahtar Kelimeler

• Insulin resistance
• adiponectin
• adiponectin gene polymorphism

Tip 2 Diyabet Mellituslu Hastalarının Birinci Derece Akrabalarında İnsülin Direnci, Serum Adiponektin ve Adiponektin Gen Polimorfizmi

Öz

Amaç: Tip 2 Diyabet Mellitus (T2DM) hastalarının birinci derece akrabalarında insülin direnci, serum adiponektin seviyeleri ve adiponektin gen polimorfizminin araştırılması. Gereç ve Yöntemler: T2DM’li bireylerin birinci derece akrabalarından dahil edilme kriterlerini karşılayan 142 kişi (34 erkek, 108 kadın) çalışmaya dahil edildi. Kontrol grubu 80 sağlıklı yetişkinden (15 erkek, 65 kadın) oluşturuldu. Tüm katılımcıların kan basıncı, bel ve kalça çevreleri ölçüldü. Açlık glukoz ve insülin seviyeleri, lipid profili, serum adiponektin düzeyi ve adiponektin gen poliformizmi çalışıldı ve 75 gram glukoz ile oral glukoz tolerans testi yapıldı. HOMA-IR yöntemiyle insülin direnci hesaplandı. Bulgular: T2DM'li bireylerin birinci derece akrabalarında HOMA-IR değeri, Total-Kolesterol, LDL-Kolesterol ve trigliserid düzeyleri kontrol grubuna göre anlamlı yüksek, HDL-Kolesterol düzeyi anlamlı düşük bulundu. Glukoz tolerans bozukluğu çalışma grubunda daha yaygındı. Serum adiponektin düzeyleri çalışma grubunda anlamlı derecede daha düşüktü. Adiponektin gen polimorfizmi iki grup arasında benzerlik gösterdi. Sonuç: T2DM'li hastaların birinci derece akrabalarında daha yüksek HOMA-IR ve daha düşük serum adiponektin seviyelerinin saptanması bu bireylerde metabolik fonksiyonlarda bozulma olduğunu düşündürmektedir. Ancak adiponektin gen polimorfizmi çalışma ve kontrol grupları arasında benzerlik göstermiştir. Adiponektin gen polimorfizminin diyabet gelişimi ve bozulmuş metabolik fonksiyonlar üzerindeki etkisini belirlemek için, çevresel faktörler ve yaşam tarzı da dikkate alınarak, tek gen polimorfizmi ve multi allel incelemelerle desteklenen daha geniş çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• İnsülin direnci
• adiponektin
• adiponektin gen polimorfizmi

Kaynakça

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