COMPARISON OF 18F-FDG PET/CT DATA WİTH TYPE 2 DIABETES AND OBESITY IN BREAST CANCER

Yıl 2025, Cilt: 27 Sayı: 3, 306 - 311, 25.12.2025

Özge Ulaş Babacan , Zekiye Hasbek

https://doi.org/10.24938/kutfd.1696624

Öz

Objective: The aim of the present study was to evaluate the association of obesity and diabetes with 18F-FDG PET/CT SUVmax values and metastasis in breast cancer patients.
Material and Methods: The study included 126 breast cancer patients who underwent 18F-FDG PET/CT for staging between 2023 and 2024.
Results: There was no significant correlation between the presence of obesity and breast tumour SUVmax value (p=0.427). There was no significant relationship between body mass index and metastatic lymph node SUVmax and distant metastasis SUVmax (p=0.06, p=0.457). There was no significant association between the presence or absence of diabetes and distant metastasis SUVmax or lymph node metastasis SUVmax on 18F-FDG PET/CT (p=0.723, p=0.581). In our study, there was no significant difference in the 18F-FDG PET/CT findings of breast cancer patients with diabetes at the time of diagnosis compared to women without diabetes. In addition, although not statistically significant, we found that the median SUVmax values for lymph node and distant metastases were significantly higher in obese and morbidly obese patients compared to other patients. Therefore, we think that breast cancer patients should be followed up more closely in the follow-up of obese and diabetic patients, taking these conditions into consideration and patients should be advised to lose weight.
Conclusion: In conclusion, although we did not find a significant association between body mass indeks and diabetes and breast cancer in our study, we think that this may be due to the small number of patients. We also found that the risk of axillary lymph node metastasis increased as breast tumor SUVmax increased and the cut-off value for breast tumor SUVmax was 5.15. We think that the presence of lymph node metastasis on PET/CT should be reported carefully, taking into account the SUVmax value.

Anahtar Kelimeler

Breast cancer , body mass ındex , diabetes mellitus

Meme Kanserinde Diyabet ve Obezite Varlığı ile F18- FDG PET/BT Verilerinin Karşılaştırması

Öz

Amaç: Bu çalışmadaki amacımız, meme kanseri hastalarında obezite ve diyabetin 18F-FDG PET/BT SUVmax değerleri ve metastaz ile ilişkisini değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya 2023 ve 2024 yılları arasında evreleme için 18F-FDG PET/BT çekilen 126 meme kanseri hastası dahil edilmiştir.
Bulgular: Obezite varlığı ile meme tümörü SUVmax değeri arasında anlamlı bir korelasyon yoktu (p=0,427). Beden kitle indeksi ile uzak metastaz SUVmax değeri ve metastatik lenf nodu SUVmax değeri arasında anlamlı bir korelasyon yoktu (p=0,06, p=0,457). Diyabet varlığı veya yokluğu ile 18F-FDG PET/BT'de uzak metastaz SUVmax veya metastatik lenf nodu SUVmax değerleri arasında anlamlı bir ilişki bulunmamıştır (p=0,723, p=0,581). Çalışmamızda tanı anında diyabeti olan meme kanserli hastaların 18F-FDG PET/BT bulgularında diyabeti olmayan kadınlara göre anlamlı bir fark bulunmamıştır. Ayrıca, istatistiksel olarak anlamlı olmasa da, lenf nodu ve uzak metastazlar için ortanca SUVmax değerlerinin obez ve morbid obez hastalarda diğer hastalara kıyasla anlamlı derecede yüksek olduğunu tespit ettik. Bu nedenle meme kanseri hastalarının takibinde obez ve diyabetik hastaların bu durumları göz önünde bulundurularak daha yakından takip edilmesi ve hastalara kilo vermelerinin önerilmesi gerektiğini düşünüyoruz.
Sonuç: Sonuç olarak, çalışmamızda beden kitle indeksi ve diyabet ile meme kanseri arasında anlamlı bir ilişki bulamamış olsak da, bunun hasta sayısının azlığından olabileceğini düşünüyoruz. Ayrıca, meme tümörü SUVmax değeri arttıkça aksiller lenf nodu metastazı riskinin arttığını ve meme tümörü SUVmax değeri için cut-off değerinin 5,15 olduğunu bulduk. PET/BT'de lenf nodu metastazı varlığının SUVmax değeri dikkate alınarak dikkatli bir şekilde raporlanması gerektiğini düşünüyoruz.

Anahtar Kelimeler

Meme kanseri , beden kitle indeksi , diyabet

Kaynakça

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