SİSPLATİN OTOTOKSİSİTESİ

Burak Taş; Gökçe Şimşek

doi:10.24938/kutfd.306905

SİSPLATİN OTOTOKSİSİTESİ

Öz

Ototoksisite çeşitli ilaçlar ve kimyasal maddelerin koklea ve vestibüler organda oluşturduğu hücresel dejenerasyon ve fonksiyon bozukluğudur. Sisplatin (Cis-diamindiklorplatinum II) özellikle baş-boyun tümörlerinde, ürogenital sistem, santral sinir sistemi, solunum sistemi ve özefagus kanserleri olmak üzere birçok malign hastalığın tedavisinde erişkinlerde ve çocuklarda kullanılmakta olan antineoplastik bir ajandır. Sisplatinin nefrotoksisite ve geri dönüşümsüz ototoksisite dışında diğer önemli doz sınırlayıcı yan etkileri nörotoksisite, gastrointestinal sistem ve kemik iliği toksisitesidir. Sisplatin ototoksik etkisini reaktif oksijen ürünleri ve DNA hasarı ile göstermektedir. Sisplatin ototoksisitesinde klinik olarak başlangışta yüksek frekanslarda, sonrasında konuşma sesini de içeren düşük frekanslarda, bilateral, sensorinöral işitme kaybı görülür. Günümüzde sisplatin bağımlı ototoksisiteyi önlemede standart bir tedavi bulunmamaktadır. Bu derlemede sisplatin ototoksisitesinin tanımı, etki mekanizması, güncel tedavi seçenekleri güncel literatür bilgileri eşliğinde tartışılmıştır.

Anahtar Kelimeler

Sisplatin,ototoksisite,önleme,koklea,işitme kaybı,antioksidan

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Burak Taş
Kırıkkale Üniversitesi, Tıp Fakültesi, KBB Anabilim Dalı
Türkiye

Gökçe Şimşek
Kırıkkale Üniversitesi, Tıp Fakültesi, KBB Anabilim Dalı
Türkiye

Yayımlanma Tarihi

24 Nisan 2017

Gönderilme Tarihi

18 Nisan 2017

Kabul Tarihi

21 Nisan 2017

Yayımlandığı Sayı

Yıl 2017 Cilt: 19 Sayı: 1

DOI

https://doi.org/10.24938/kutfd.306905

IZ

https://izlik.org/JA52KZ29SE

Kaynak Göster

RIS / Bibtex

APA

Taş, B., & Şimşek, G. (2017). SİSPLATİN OTOTOKSİSİTESİ. The Journal of Kırıkkale University Faculty of Medicine, 19(1), 30-36. https://doi.org/10.24938/kutfd.306905

AMA

1.Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üni Tıp Derg. 2017;19(1):30-36. doi:10.24938/kutfd.306905

Chicago

Taş, Burak, ve Gökçe Şimşek. 2017. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine 19 (1): 30-36. https://doi.org/10.24938/kutfd.306905.

EndNote

Taş B, Şimşek G (01 Nisan 2017) SİSPLATİN OTOTOKSİSİTESİ. The Journal of Kırıkkale University Faculty of Medicine 19 1 30–36.

IEEE

[1]B. Taş ve G. Şimşek, “SİSPLATİN OTOTOKSİSİTESİ”, Kırıkkale Üni Tıp Derg, c. 19, sy 1, ss. 30–36, Nis. 2017, doi: 10.24938/kutfd.306905.

ISNAD

Taş, Burak - Şimşek, Gökçe. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine 19/1 (01 Nisan 2017): 30-36. https://doi.org/10.24938/kutfd.306905.

JAMA

1.Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üni Tıp Derg. 2017;19:30–36.

MLA

Taş, Burak, ve Gökçe Şimşek. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine, c. 19, sy 1, Nisan 2017, ss. 30-36, doi:10.24938/kutfd.306905.

Vancouver

1.Burak Taş, Gökçe Şimşek. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üni Tıp Derg. 01 Nisan 2017;19(1):30-6. doi:10.24938/kutfd.306905

Cited By

Comparison of the protective efficacy between intratympanic dexamethasone and resveratrol treatments against cisplatin-induced ototoxicity: an experimental study

European Archives of Oto-Rhino-Laryngology

https://doi.org/10.1007/s00405-019-05635-x