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SİSPLATİN OTOTOKSİSİTESİ

Yıl 2017, , 30 - 36, 24.04.2017
https://doi.org/10.24938/kutfd.306905

Öz

Ototoksisite
çeşitli ilaçlar ve kimyasal maddelerin koklea ve vestibüler organda oluşturduğu
hücresel dejenerasyon ve fonksiyon bozukluğudur. Sisplatin
(Cis-diamindiklorplatinum II) özellikle baş-boyun tümörlerinde, ürogenital
sistem, santral sinir sistemi, solunum sistemi ve özefagus kanserleri olmak
üzere birçok malign hastalığın tedavisinde erişkinlerde ve çocuklarda
kullanılmakta olan antineoplastik bir ajandır. Sisplatinin nefrotoksisite ve
geri dönüşümsüz ototoksisite dışında diğer önemli doz sınırlayıcı yan etkileri nörotoksisite,
gastrointestinal sistem ve kemik iliği toksisitesidir. Sisplatin ototoksik
etkisini reaktif oksijen ürünleri ve DNA hasarı ile göstermektedir. Sisplatin
ototoksisitesinde klinik olarak başlangışta yüksek frekanslarda, sonrasında
konuşma sesini de içeren düşük frekanslarda, bilateral, sensorinöral işitme
kaybı görülür. Günümüzde sisplatin bağımlı ototoksisiteyi önlemede standart bir
tedavi bulunmamaktadır. Bu derlemede sisplatin ototoksisitesinin tanımı, etki
mekanizması, güncel tedavi seçenekleri güncel literatür bilgileri eşliğinde
tartışılmıştır.

Kaynakça

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Toplam 53 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Burak Taş

Gökçe Şimşek

Yayımlanma Tarihi 24 Nisan 2017
Gönderilme Tarihi 18 Nisan 2017
Yayımlandığı Sayı Yıl 2017

Kaynak Göster

APA Taş, B., & Şimşek, G. (2017). SİSPLATİN OTOTOKSİSİTESİ. The Journal of Kırıkkale University Faculty of Medicine, 19(1), 30-36. https://doi.org/10.24938/kutfd.306905
AMA Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üni Tıp Derg. Nisan 2017;19(1):30-36. doi:10.24938/kutfd.306905
Chicago Taş, Burak, ve Gökçe Şimşek. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine 19, sy. 1 (Nisan 2017): 30-36. https://doi.org/10.24938/kutfd.306905.
EndNote Taş B, Şimşek G (01 Nisan 2017) SİSPLATİN OTOTOKSİSİTESİ. The Journal of Kırıkkale University Faculty of Medicine 19 1 30–36.
IEEE B. Taş ve G. Şimşek, “SİSPLATİN OTOTOKSİSİTESİ”, Kırıkkale Üni Tıp Derg, c. 19, sy. 1, ss. 30–36, 2017, doi: 10.24938/kutfd.306905.
ISNAD Taş, Burak - Şimşek, Gökçe. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine 19/1 (Nisan 2017), 30-36. https://doi.org/10.24938/kutfd.306905.
JAMA Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üni Tıp Derg. 2017;19:30–36.
MLA Taş, Burak ve Gökçe Şimşek. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine, c. 19, sy. 1, 2017, ss. 30-36, doi:10.24938/kutfd.306905.
Vancouver Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Üni Tıp Derg. 2017;19(1):30-6.

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