MAY SINGLE ONE LEVEL INTRADISCAL AUTOLOGOUS PLATELET RICH PLASMA INJECTION PLAY A ROLE IN THE TREATMENT OF DISCOGENIC PAIN? RESULTS AT SIX MONTH FOLLOW-UP

Öz

Objective: Low back pain is spreading both in older and younger people in a fast manner. Discogenic pain resulting from degeneration of the intervertebral disc is responsible for 40% or more of the cases of low back pain. We hypothesized that single one level intradiscal autologous platelet rich plasma (PRP) injection might provide remarkable pain relief and return to pre-illness activity level in the patients suffering from discogenic pain.

Material and Methods: Twenty-two patients underwent injections of just one 3ml dose of PRP into one intervertebral disc space (single one level intradiscal autologous PRP injection) for discogenic pain. The patients were evaluated by visual analogue score (VAS) and Oswestry Disability Index (ODI) score before intradiscal PRP treatment and at six months after intradiscal PRP treatment.

Results: The average pre-treatment VAS and ODI scores were 5.6±1.0 and 55.0% ± 11.6% respectively. The average VAS and ODI scores at six months after intradiscal PRP treatment were 1.3±1.0 and 23.2% ± 11.2% respectively and the differences were statistically significant (p<0.01).

Conclusion: The present study demonstrates that single one level intradiscal PRP injection may provide remarkable pain relief and may increase the return to pre-illness activity level in the patients suffering from discogenic pain. For evaluation of the efficacy of this treatment, randomized placebo-controlled trials are needed.

Anahtar Kelimeler

• PRP,intervertebral,disc degeneration,Oswestry Disability Index,low back pain

Bir Seviye Tek Sefer İntradiskal Otolog Plateletten Zengin Plazma Enjeksiyonu Diskojenik Ağrı Tedavisinde Rol Oynayabilir mi? 6. Ay Takip Sonuçları

Öz

Amaç: Bel ağrısı hem genç hem de yaşlı nüfusta gittikçe artan bir oranda görülmektedir. İntervertebral disk dejenerasyonu neticesinde gelişen diskojenik ağrı, kronik bel ağrısı şikayetlerinin yaklaşık %40’ının sebebidir. Bizim bu çalışmadaki hipotezimiz diskojenik ağrı tedavisinde bir seviye tek sefer otolog intradiskal plateletten zengin plazma (PZP) uygulamasının hastaların fiziksel aktiviteye dönüşü ve ağrı üzerinde belirgin bir iyileşme sağlayabileceğidir.

Gereç ve Yöntemler: Diskojenik ağrı tedavisi için 22 hastaya bir seviye tek sefer 3ml intradiskal otolog platelet zengin plazma (PZP) uygulaması yapıldı. Hastalar tedavi öncesi ve tedaviden 6 ay sonra vizüel analog skor (VAS) ve Oswestry disabilite index (ODI) ile değerlendirildi.

Bulgular: Tedavi öncesi ortalama VAS ve ODI skorları sırası ile 5.6±1.0 ve %55.0 ± %11.6 idi. Tedaviden 6 ay sonra ortalama VAS ve ODI skorları sırası ile 1.3±1.0 ve %23.2 ± %11.2 idi ve fark istatistiksel olarak anlamlı bulundu (p<0.01).

Sonuç: Çalışmamız kronik diskojenik ağrı hastalarında bir seviye tek sefer intradiskal PZP uygulamasının hastaların fiziksel aktiviteye dönüşü ve ağrı üzerinde belirgin bir iyileşme sağlayabileceğini göstermiştir. Intradiskal PZP tedavisnin etkinliğini daha derinlemesine araştırmak için randomize plasebo kontrollü çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• PZP,intervertebral,disk dejenerasyonu,bel ağrısı,Oswestry Disability Index

Kaynakça

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