The Effect of Carprofen Treatment on Conception Rate After Insemination in Cows with Increased Days in Milk

Abstract

In this study the effect of carprofen treatment on conception rate after insemination in Holstein cows that did not conceive for a long time after parturition was evaluated. In the study, 200 Holstein cows with days in milk >120 were used. A progesterone + ovsynch-based estrus synchronization protocol was applied to the cows included in the study. For this purpose, the progesterone device was placed intravaginally together with GnRH injection. Seven days later, the progesterone source was removed from the vagina and PGF2α injection was administered. GnRH injection was administered 48 hours following PGF2α injection and fixed-time insemination was performed 12-16 hours later. After insemination, animals were randomly divided into 2 groups. Subcutaneous carprofen was applied to the carprofen group (n = 100) on the 14th day after insemination and physiological saline was applied to the control group (n = 100) on the same day. Three cows from the carprofen group and 5 cows from the control group were excluded from the study for various reasons. The pregnancy rate was 42.26% (41/97) in the carprofen group and 25.26% (24/95) in the control group (p <0.05). However, the rate of conception was found to be the lowest (10.52%) in cows with high milk yield (>30 kg) in the control group. In addition, it was found that carprofen administration to cows with high milk yield increased the rate of conception. However, it was determined that the days in milk had no effect on pregnancy rate. As a result, it was concluded that the administration of carprofen on the 14th day after insemination to cows who could not conceive for a long time after parturition may be effective in increasing the rate of conception.

Keywords

• Carprofen
• cow
• days in milk
• milk yield
• pregnancy rate

Sağımda Geçen Gün Süresi Artmış Olan İneklerde Tohumlama Sonrası Karprofen Uygulamasının Gebe Kalma Oranı Üzerine Etkisi

Öz

Bu çalışmada doğumdan sonra uzun süre gebeliğin sağlanamadığı Holstein ırkı ineklerde, tohumlama sonrası karprofen uygulamasının gebe kalma oranı üzerine etkisi değerlendirilmiştir. Çalışmada sağımda geçen gün süresi ˃120 gün olan 200 Holstein ırkı inek kullanıldı. Çalışmaya dahil edilen ineklere progesteron+ovsynch esaslı östrüs senkronizasyon protokolü uygulandı. Bu amaçla GnRH enjeksiyonu ile birlikte progesteron kaynağı intravaginal olarak yerleştirildi. Yedi gün sonra progesteron kaynağı vaginadan uzaklaştırıldı ve PGF2α enjeksiyonu yapıldı. PGF2α enjeksiyonundan 48 saat sonra GnRH enjeksiyonu uygulandı ve 12-16 saat sonra ineklere sabit zamanlı tohumlama yapıldı. Tohumlama sonrası hayvanlar rastgele olarak 2 gruba ayrıldı. Karprofen grubuna (n=100) tohumlama sonrası 14. gün deri altı karprofen ve kontrol grubuna (n=100) ise aynı gün fizyolojik tuzlu su uygulandı. Karprofen grubundan 3 ve kontrol grubundan ise 5 inek çeşitli nedenlerle çalışmadan çıkarıldı. Gebe kalma oranı; karprofen grubunda %42,26 (41/97), kontrol grubunda ise %25,26 (24/95) olarak belirlendi (p<0,05). Bununla birlikte kontrol grubunda yüksek süt verimli (≥30 kg) ineklerde gebe kalma oranları en düşük (%10,52) bulundu. Ayrıca yüksek süt verimli ineklere karprofen uygulamasının gebe kalma oranını artırdığı tespit edildi. Ancak sağımda geçen gün süresinin gebelik oranı üzerine etkisinin olmadığı belirlendi. Sonuç olarak doğumdan sonra uzun bir süre gebe kalamamış ineklere, tohumlama sonrası 14. günde karprofen uygulamasının gebe kalma oranını artırmada etkili olabileceği kanısına varıldı.

Anahtar Kelimeler

• Gebelik oranı
• inek
• karprofen
• sağımda geçen gün süresi
• süt verimi

Kaynakça

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